Zobrazeno 1 - 10
of 33
pro vyhledávání: '"J W, Lazarewicz"'
Publikováno v:
Molecular Neurobiology. 59:5452-5475
Publikováno v:
Molecular neurobiology. 59(9)
Autism spectrum disorders (ASDs) are increasingly diagnosed as developmental disabilities of unclear etiology related to genetic, epigenetic, or environmental factors. The diagnosis of ASD in children is based on the recognition of typical behavioral
Publikováno v:
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 65(5)
Tetrabromobisphenol A (TBBPA) is a commonly used brominated flame retardant with recognized neuro- and cytotoxic properties that are presumably mediated by intracellular Ca(2+) release. Other studies have demonstrated that ryanodine is able to inhibi
Publikováno v:
Neurotoxicology. 21(3)
Exposure of rat cerebral mitochondria to 2-10 mM glutamine (Gln) for 20 min, produced a concentration-dependent, gradual decrease of light scattering reflecting mitochondrial swelling. The light scattering decreasing effect of 5 mM Gln was attenuated
Publikováno v:
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 85(1)
In vivo microdialysis combined with measurements of 45Ca efflux from pre-labelled rat hippocampus has been utilised in our laboratory to demonstrate NMDA-evoked 45Ca2+ release to dialysate, reflecting calcium-induced calcium release (CICR) via ryanod
Publikováno v:
Acta neurobiologiae experimentalis. 58(4)
Caffeine in 10(-2) M concentration per se activates ryanodine receptors (RyR) in vitro, thereby increasing the intracellular concentration of Ca2+ ([Ca2+]i). In general opinion, caffeine applied in vivo in much lower doses does not affect [Ca2+]i in
Autor:
J W, Lazarewicz, W, Rybkowski, M, Sadowski, A, Ziembowicz, M, Alaraj, J, Wegiel, H M, Wisniewski
Publikováno v:
Journal of neuroscience research. 51(1)
Previously, by using in vivo microdialysis, we demonstrated a huge release of 45Ca2+ from prelabeled tissues to dialysate that was evoked by application of N-methyl-D-aspartate (NMDA) to the rat dentate gyrus (DG) and sector 4 of the cornu ammonis. T
Publikováno v:
Journal of neural transmission (Vienna, Austria : 1996). 104(11-12)
Novel antagonists of the glycineB site of the NMDA receptor (MRZ 2/570, MRZ 2/576), and an AMPA receptor antagonist, NBQX were tested in 3-min global ischaemia in gerbils. Untreated animals showed after 14 days a loss of almost 90% of pyramidal neuro
Autor:
J W, Lazarewicz, W, Rybkowski
Publikováno v:
Acta neurobiologiae experimentalis. 56(2)
Recently we detected NMDA-induced 45Ca release in the rat dentate gyrus in vivo, attributable to the Ca2+ induced Ca2+ release (CICR) from the endoplasmic reticulum via ryanodine channels. In these experiments we compare expression of NMDA-evoked 45C
Autor:
E, Salińska, J W, Lazarewicz
Publikováno v:
Neurologia i neurochirurgia polska. 30
Excitotoxic hypothesis of ischemic brain lesion postulates a causal relation between stimulation of glutamatergic receptors and potentially neurotoxic neuronal calcium overload. In this short review we sum up our microdialysis studies on NMDA- and is