Phenotypic variation in a large Swedish pedigree due toSNCAduplication and triplication

Autor: Marita Munz, Christer Nilsson, Julia Fuchs, Matthew J. Farrer, Thomas Gasser, Mary M. Hulihan, Owen A. Ross, Elna-Marie Larsson, Frank A. Middleton, Birgitt Schüle, Jennifer M. Kachergus, J. W. Langston

Publikováno v: Neurology
Neurology, American Academy of Neurology, 2007, 68 (12), pp.916-922. ⟨10.1212/01.wnl.0000254458.17630.c5⟩
Fuchs, J, Nilsson, C, Kachergus, J, Munz, M, Larsson, E-M, Schüle, B, Langston, J W, Middleton, F A, Ross, O A, Hulihan, M, Gasser, T & Farrer, M J 2007, ' Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication. ', Neurology, vol. 68, no. 12, pp. 916-22 . https://doi.org/10.1212/01.wnl.0000254458.17630.c5

BACKGROUND: The "Lister family complex," an extensive Swedish family with autosomal dominant Parkinson disease, was first described by Henry Mjönes in 1949. On the basis of clinical, molecular, and genealogic findings on a Swedish and an American fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d02631bf570a5de135ebc514256058
https://doi.org/10.1212/01.wnl.0000254458.17630.c5

Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration

Autor: Donato A. Di Monte, J. W. Langston, Alison L. McCormack, J.G. Atienza

Publikováno v: Neuroscience. 141:929-937

The vulnerability of different dopaminergic cell populations to damage caused by the herbicide paraquat was assessed by stereological counts of tyrosine hydroxylase-positive and calbindin-D28k-immunoreactive neurons in A9 (substantia nigra pars compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45233848faa19cb1922e5ff9fe271018
https://doi.org/10.1016/j.neuroscience.2006.03.069

Novel observations with FDOPA-PET imaging after early nigrostriatal damage

Autor: Daniel M. Togasaki, I Irwin, C Milonas, Keyvan Farahani, Ann Marie Janson, J. W. Langston, Nagichettiar Satyamurthy, Louis E. DeLanney, Michael E. Phelps, David B. Stout, K Delfani, Jorge R. Barrio, Randa E. Yee, Kooresh Shoghi-Jadid, S.-C. Huang

Publikováno v: Movement Disorders. 16:838-848

Striatal 6-[ 18 F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3f8e6a46f2b7273deb3beece07eeafb
https://doi.org/10.1002/mds.1168

Quantification of dyskinesia in Parkinson's disease: Validation of a novel instrumental method

Autor: J W Langston, Pierre R. Burkhard, James W. Tetrud, H Shale

Publikováno v: Movement Disorders. 14:754-763

We used a rotation-sensitive movement monitor (RoMM) to quantify and characterize dyskinesia in Parkinson's disease (PD). Both upper limbs of 22 patients with dyskinetic PD were recorded and videotaped simultaneously. Three neurologists reviewed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b7650a1152ccd034a616afb7e45d72e
https://doi.org/10.1002/1531-8257(199909)14:5<754::aid-mds1007>3.0.co

The Postnatal Development of AMPA Receptor Subunits in the Basal Ganglia of the Rat

Autor: Vernice Jackson-Lewis, Michael W. Jakowec, Serge Przedborski, X Chen, J. W. Langston

Publikováno v: Developmental Neuroscience. 20:19-33

In situ hybridization and immunohistochemistry were used to characterize the expression pattern of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors during postnatal development in the rat basal ganglia. All subunit transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64eaa95120833bb1d3ef8715febd6b64
https://doi.org/10.1159/000017295