Výsledky vyhledávání - "J W, Huggins"

A mouse model of aerosol-transmitted orthopoxviral disease: morphology of experimental aerosol-transmitted orthopoxviral disease in a cowpox virus-BALB/c mouse system

Autor: M J, Martinez, M P, Bray, J W, Huggins

Publikováno v: Archives of pathologylaboratory medicine. 124(3)

To determine the morphologic changes and disease progression of aerosolized cowpox virus infection in BALB/c mice and to ascertain the suitability of cowpox virus-infected BALB/c mice as a model of aerosol-transmitted, orthopoxviral respiratory disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2da6e34efead0bfa98512c48572894d
https://pubmed.ncbi.nlm.nih.gov/10705388

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Pathology of experimental Ebola virus infection in African green monkeys. Involvement of fibroblastic reticular cells

Autor: K J, Davis, A O, Anderson, T W, Geisbert, K E, Steele, J B, Geisbert, P, Vogel, B M, Connolly, J W, Huggins, P B, Jahrling, N K, Jaax

Publikováno v: Archives of pathologylaboratory medicine. 121(8)

Ebola virus has been responsible for explosive lethal outbreaks of hemorrhagic fever in both humans and nonhuman primates. Previous studies showed a predilection of Ebola virus for cells of the mononuclear phagocyte system and endothelial cells.To ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12f3c4219cb0b8e3abddaa0ca1a84674
https://pubmed.ncbi.nlm.nih.gov/9278608

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Passive immunization of Ebola virus-infected cynomolgus monkeys with immunoglobulin from hyperimmune horses

Autor: P B, Jahrling, J, Geisbert, J R, Swearengen, G P, Jaax, T, Lewis, J W, Huggins, J J, Schmidt, J W, LeDuc, C J, Peters

Publikováno v: Archives of virology. Supplementum. 11

A commercially available immunoglobulin G (IgG) from horses, hyperimmunized to Ebola virus, was evaluated for its ability to protect cynomolgus monkeys against disease following i.m. inoculation with 1 000 PFU Ebola virus (Zaire '95 strain). Six monk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10280f0f22d38d021c83744700329c5a
https://pubmed.ncbi.nlm.nih.gov/8800795

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Pharmacokinetics of the antiviral agent 3-deazaneplanocin A

Autor: J. W. Huggins, Raghubir P. Sharma, Roger A. Coulombe

Publikováno v: European journal of drug metabolism and pharmacokinetics. 20(3)

The pharmacokinetics of 3-deazaneplanocin A (c3Nep), a competitive inhibitor of S-adenosyl-L-homocysteine (AdoHcy) hydrolase and novel antiviral agent, was investigated in female BALB/c mice. Animals were given a single intravenous dose of [3H]-c3Nep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3aa67bb2c03f975ac8b4b801ec9530e
https://pubmed.ncbi.nlm.nih.gov/8751041

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Early analysis of viremia and clinical tests in patients with epidemic hemorrhagic fever

Autor: T M, Zhang, Z Q, Yang, M Y, Zhang, Z J, Hu, J M, Xiang, J W, Huggins, T M, Cosgriff, J I, Smith

Publikováno v: Chinese medical journal. 106(8)

We analysed the early viremia and clinical tests in 82 patients with epidemic hemorrhagic fever (EHF). The results showed that the changes in viremia and clinical tests are related to the severity of the disease and prognosis. Higher concentrations o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::133e0692424714b443094cef6c2a01c0
https://pubmed.ncbi.nlm.nih.gov/7900974

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Pharmacokinetics of the antiviral agent carbocyclic 3-deazaadenosine

Autor: R A, Coulombe, J M, Huie, R P, Sharma, J W, Huggins

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(4)

The pharmacokinetics of carbocyclic 3-deazaadenosine (Cc3Ado), a competitive inhibitor of S-adenosyl-L-homocysteine hydrolase and novel antiviral agent, was investigated in female BALB/c mice. Mice were dosed either orally or intravenously with a sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49cda7ccd385d7956ce425ea9e2bf8df
https://pubmed.ncbi.nlm.nih.gov/8104112

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Interruption study of viremia of patients with hemorrhagic fever with renal syndrome in the febrile phase

Autor: Z Q, Yang, T M, Zhang, M V, Zhang, Z M, Zheng, Z J, Hu, C F, Qu, J M, Xiang, J W, Huggins, T M, Cosgriff, J I, Smith

Publikováno v: Chinese medical journal. 104(2)

Kinetic changes of viremia were observed in 287 cases of hemorrhagic fever with renal syndrome (HFRS) in whom ribavirin was administered with double blind random control studied by means of virus isolation, indirect immunofluorescence assay and enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bad66b17ca6a34d265e0583601436ec
https://pubmed.ncbi.nlm.nih.gov/1678691

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Ecto-enzymes of mammary gland and its tumors. Lectin inhibition of 5'-nucleotidase of the 13762 rat mammary ascites carcinoma

Autor: K L, Carraway, D D, Fogle, R W, Chestnut, J W, Huggins, C A, Carraway

Publikováno v: The Journal of biological chemistry. 251(20)

Lectin inactivation of the cell surface enzyme 5'-nucleotidase has been studied in intact 13762 mammary ascites cells, cell membrane envelopes, membrane vesicles, and solubilized membranes as a means of understanding the effects of lectins on biochem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dada8b7dd80669fbd5ec15caf04d964a
https://pubmed.ncbi.nlm.nih.gov/977563

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