Výsledky vyhledávání - "J W, Harbour"

Combined PKC and MEK inhibition for treating metastatic uveal melanoma

Autor: Justin Stebbing, Anne M. Bowcock, Mandeep S. Sagoo, J W Harbour

Uveal melanoma (UM) is a genetically and biologically distinct type of melanoma, and once metastatic there is no effective treatment currently available. 80% of UMs harbor mutations in the Gαq family members GNAQ and GNA11. Understanding the effecto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34e6cd11c8eb0564fbf4fc00870f327
https://europepmc.org/articles/PMC4356624/

Zobrazit plný text záznamu

Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi

Autor: Mae O. Gordon, H Hollingsworth, J W Harbour, Milam A. Brantley

Aim: To investigate the association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi. Methods: Cross sectional study of 65 patients with posterior uveal melanoma and 218 controls. Iris colour, iris freckles, iris na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc33d4bbb8fd7aca26799985d5d0257b
https://europepmc.org/articles/PMC1771959/

Zobrazit plný text záznamu

A new mutation with staggering effects

Autor: J. W. Harbour

Publikováno v: Pigment Cell & Melanoma Research. 24:1081-1082

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f4cf87ddb1aabaa5bc1e972045afc08
https://doi.org/10.1111/j.1755-148x.2011.00928.x

Zobrazit plný text záznamu

Corepressors and Retinoblastoma Protein Function

Autor: J. W. Harbour, D. C. Dean

Publikováno v: Current Topics in Microbiology and Immunology ISBN: 9783642087097

The retinoblastoma protein (Rb) is a ubiquitous transcriptional repressor and a negative regulator of the Gl-to-S phase transition in the eukaryotic cell cycle. Through this inhibitory activity, Rb plays a critical role in suppressing neoplastic tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ae2e5c1775e882dbecae88037be7215
https://doi.org/10.1007/978-3-662-10595-5_7

Zobrazit plný text záznamu

Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region

Autor: M A, Brantley, J W, Harbour

Publikováno v: Cancer research. 60(16)

Uveal melanoma is the most common malignancy of the eye, but little is known about its underlying genetic defects. Melanomas of uveal origin, unlike those of the skin, are rarely familial and have not been linked consistently to mutations in tumor su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5df5deec90bc1b5e230dcc3fb6e696b6
https://pubmed.ncbi.nlm.nih.gov/10969768

Zobrazit plný text záznamu

Overview of RB gene mutations in patients with retinoblastoma. Implications for clinical genetic screening

Autor: J W, Harbour

Publikováno v: Ophthalmology. 105(8)

This study aimed to determine the distribution of germline mutations in the retinoblastoma (RB) gene in patients with retinoblastoma to design more effective genetic testing.A meta-analysis.192 cases identified from literature.All identifiable report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9b3803c183079e426af4becfbfcdd16
https://pubmed.ncbi.nlm.nih.gov/9709755

Zobrazit plný text záznamu

Local carboplatin therapy in transgenic murine retinoblastoma

Autor: J W, Harbour, T G, Murray, D, Hamasaki, N, Cicciarelli, E, Hernández, B, Smith, J, Windle, J M, O'Brien

Publikováno v: Investigative ophthalmologyvisual science. 37(9)

To determine the efficacy and toxicity associated with intraocular delivery of carboplatin in the treatment of murine transgenic hereditary retinoblastoma.Forty-eight transgenic BLH-SV40 Tag retinoblastoma mice were administered five intravitreal inj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::458ef93a2c7a164ab4fd3905c468e416
https://pubmed.ncbi.nlm.nih.gov/8759359

Zobrazit plný text záznamu

Vitrectomy for diabetic macular edema associated with a thickened and taut posterior hyaloid membrane

Autor: Harry W. Flynn, Patrick E. Rubsamen, J. W. Harbour, William E. Smiddy

Publikováno v: American journal of ophthalmology. 121(4)

Purpose To evaluate the surgical results in a series of patients with diabetic macular edema associated with traction from a thickened and taut posterior hyaloid membrane and to identify features associated with better visual outcome. Methods We revi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba3a062f25e1d4fa5b5c8edd8fe3e04
https://pubmed.ncbi.nlm.nih.gov/8604734

Zobrazit plný text záznamu

Uveal metastasis from carcinoid tumor. Clinical observations in nine cases

Autor: J W, Harbour, P, De Potter, C L, Shields, J A, Shields

Publikováno v: Ophthalmology. 101(6)

Carcinoid tumor is a low-grade malignancy that usually arises in the gastrointestinal tract or bronchus and rarely metastasizes to the eye. Metastasis of carcinoid tumor to the uvea can be confused clinically with other primary and metastatic uveal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74d6904edd3e9e990c3b9b9f0fadd926
https://pubmed.ncbi.nlm.nih.gov/8008351

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání