Výsledky vyhledávání - "J W, Goldman"

Phase 1 Dose-Escalation Trial of the Investigational Hedgehog (HH) Pathway Inhibitor Tak-441 in Patients with Advanced Solid Tumors

Autor: S. Stewart, Asit Parikh, J. Yu, David P. Ryan, Mitesh J. Borad, S. G. Eckhardt, Lee S. Rosen, Manuel Hidalgo, S. Kuan, J. W. Goldman

Publikováno v: Annals of Oncology. 23:ix156

Background Dysregulation of the Hh pathway is a principal event in the carcinogenesis of multiple tumor types, including basal cell carcinoma. TAK-441 is an investigational, orally-available inhibitor of the G protein-coupled receptor Smoothened, a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::952909855fd4ad5323870e7b31c849a8
https://doi.org/10.1016/s0923-7534(20)33007-6

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Phase I, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of single-agent PF-03758309, an oral PAK inhibitor, in patients with advanced solid tumors

Autor: J. Gallo, S. Darang, J. W. Goldman, Linda Mileshkin, T. Blumenkopf, D. D. Wang, S. G. Eckhardt, Lee S. Rosen, J. Davison, S. Zhang, Aurora Breazna

Publikováno v: Journal of Clinical Oncology. 29:e13607-e13607

e13607^ Background: Abnormalities of the Rho family pathway are involved in different steps of malignant transformation and tumor progression. Of the many effector proteins that bind to active Rho ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36f9b1f862bbd8e70b0b4a6802d63b45
https://doi.org/10.1200/jco.2011.29.15_suppl.e13607

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A phase I dose-escalation study of the Hsp90 inhibitor STA-9090 administered once weekly in patients with solid tumors

Autor: J. W. Goldman, R. N. Raju, G. A. Gordon, V. M. Vukovic, R. Bradley, L. S. Rosen

Publikováno v: Journal of Clinical Oncology. 28:2529-2529

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::195c0651f509c038832d3882f24a9f46
https://doi.org/10.1200/jco.2010.28.15_suppl.2529

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Treatment of accidental hypothermia with peritoneal dialysis

Autor: L S, Soung, L, Swank, T S, Ing, R A, Said, J W, Goldman, J, Perez, W P, Geis

Publikováno v: Canadian Medical Association journal. 117(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46f719d0699e6a0d29b335cb177419bf
https://pubmed.ncbi.nlm.nih.gov/589543

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Ectopic parathyroid hormone syndrome. Occurrence in a case undifferentiated lymphoma with bone marrow involvement

Autor: J W, Goldman, F O, Becker

Publikováno v: Archives of internal medicine. 138(8)

A patient with hypercalcemia, hypophosphatemia, and an undifferentiated lymphoma involving only the bone marrow was treated by us. The finding of an elevated serum parathyroid hormone (PTH) level in the presence of normal parathyroid glands and incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e97604d78900269579e243f4be3c0e
https://pubmed.ncbi.nlm.nih.gov/677991

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Progressive supranuclear palsy, computed tomography, and response to antiparkinsonian drugs

Autor: J. W. Goldman, Scott Haldeman, J. Hyde, H.F.W. Pribram

Publikováno v: Neurology. 31(4)

Three patients with progressive supranuclear palsy demonstrated atrophy of the midbrain, pons, cerebellum, and cerebral hemispheres by computed tomography with horizontal, sagittal, and coronal reconstruction. Benztropine therapy resulted in improvem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841ee0ff9d06f3cc420c7a878293ab77
https://pubmed.ncbi.nlm.nih.gov/7194433

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