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pro vyhledávání: '"J W, Fowble"'
Publikováno v:
Pharmaceutical research. 16(5)
Vitamin A (retinol) and its metabolites comprise the natural retinoids. While the biological action of these molecules are thought to be primarily mediated by ca. 55 kDa nuclear retinoic acid receptors, a number of structurally similar 15-20 kDa prot
Autor:
Dennis R. Feller, E. H. Fairchild, Duane D. Miller, A. Mukhopadhyay, J. W. Fowble, J. Chang, D. J. Sober
Publikováno v:
Chemischer Informationsdienst. 13
Publikováno v:
Chemischer Informationsdienst. 10
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 202(2)
Azepatine, a potent alpha adrenergic antagonist, was catalytically reduced with tritium and hydrogen gas to form dihydroazapetine. The pA2 azapetine was 7.9 whereas that of dihydroazapetine was 6.6, corresponding to a 20-fold decrease in potency. 3H-
Publikováno v:
Chemischer Informationsdienst. 4