Zobrazeno 1 - 10
of 19
pro vyhledávání: '"J W, Ferkany"'
Autor:
J. W. Ferkany, L. S. Silverman, Bailey Ma, Carol Tiffany, M E Abreu, Carl Kaiser, Karbon Ew, Richard Eric Mewshaw, Mathew Rm
Publikováno v:
Journal of Medicinal Chemistry. 36:3073-3076
Enantiomers of several N-substituted 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles were obtained by the resolution of 2-fluoro-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole and 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5ee9589e41e0558cbdd8a60233291a
https://doi.org/10.1021/jm00073a005
https://doi.org/10.1021/jm00073a005
Autor:
Mathew Rm, J. W. Ferkany, Karbon Ew, Richard Eric Mewshaw, Bailey Ma, Carol Tiffany, Carl Kaiser, M E Abreu, L. S. Silverman
Publikováno v:
ChemInform. 26
Enantiomers of several N-substituted 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles were obtained by the resolution of 2-fluoro-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole and 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a7824f2d4c33985e3b062816a597446
https://doi.org/10.1002/chin.199503165
https://doi.org/10.1002/chin.199503165
Autor:
R. C. Hanson, J. R. Connor, R. H. Erickson, P. V. Kaplita, J. A. Schenden, R. P. Hicks, M. E. Abreu, L. Noronha‐Blob, J. W. Ferkany
Publikováno v:
Drug Development Research. 20:429-443
The chemical synthesis of 8-aryl-1,3-dialkyl derivatives of xanthine and the ability of these compounds to interact with adenosine A1 and A2 receptors in vitro (in receptor binding, biochemical, and physiological assays) are described. NPC 205 (1,3-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f0e43833cff00988a15dbab5831263a
https://doi.org/10.1002/ddr.430200403
https://doi.org/10.1002/ddr.430200403
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(3)
The behavioral effects of the competitive N-methyl-D-aspartate (NMDA) antagonist 2R,4R,5S-2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoate (NPC 17742) were compared with those of its parent compound, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28c3ae491fbd81b79e2b14a903f53b05
https://pubmed.ncbi.nlm.nih.gov/8099615
https://pubmed.ncbi.nlm.nih.gov/8099615
Autor:
J W, Ferkany, G S, Hamilton, R J, Patch, Z, Huang, S A, Borosky, D L, Bednar, B E, Jones, R, Zubrowski, J, Willetts, E W, Karbon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 264(1)
2R,4R,5S-(2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid) (NPC 17742), the most potent isomer of the mixture 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626), was evaluated for activity in tests associated with receptors for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2190cbd201a7f488775eef68f8869ba4
https://pubmed.ncbi.nlm.nih.gov/8423528
https://pubmed.ncbi.nlm.nih.gov/8423528
Autor:
J W, Ferkany, D J, Kyle, W P, Ellenberger, B A, Narayanan, S R, Ellenberger, R, Hudkins, M E, Guzewska, W J, Rzeszotarski, L, Conti, R, Patch
Publikováno v:
Epilepsy research. Supplement. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01eb2dbf65767d6d4ad5872360712eaa
https://pubmed.ncbi.nlm.nih.gov/1418499
https://pubmed.ncbi.nlm.nih.gov/1418499
Publikováno v:
Behavioral neuroscience. 105(4)
The effects of the competitive N-methyl-D-aspartate (NMDA) antagonists CPP (510 mg/kg) and NPC 12626 (2540 mg/kg) and the noncompetitive NMDA antagonists phencyclidine (1, 3,6.25 mg/kg) and MK 801 (0.10.2 mg/kg) on performance of rats on a nonspatial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b7b2152cff2bdc7679f2b85f0f445b1
https://pubmed.ncbi.nlm.nih.gov/1657031
https://pubmed.ncbi.nlm.nih.gov/1657031
Autor:
J W, Ferkany, J T, Coyle
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 225(2)
Kainic acid (KA) exhibits both neuroexcitatory and neurotoxic actions when applied to the brain. Whereas the neuroexcitatory actions are direct, the neurotoxic effects require the integrity of excitatory afferents. In addition, specific receptors for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0dd052575c26a53593b2cee1a95d82d
https://pubmed.ncbi.nlm.nih.gov/6842403
https://pubmed.ncbi.nlm.nih.gov/6842403
Publikováno v:
Neurobehavioral toxicology and teratology. 5(6)
Kainic acid, a conformationally restricted analog of L-glutamic acid, is a potent neuroexcitant. Consistent with the excitotoxin hypothesis of Olney, intrastriatal injection of kainic acid causes degeneration of neurons with perikarya within the stri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9457d6292999a4ff0dc0c0d747cc663f
https://pubmed.ncbi.nlm.nih.gov/6142425
https://pubmed.ncbi.nlm.nih.gov/6142425
Autor:
J W, Ferkany, J T, Coyle
Publikováno v:
Life sciences. 33(13)
The specific binding of [3H]+/- 2-amino-7-phosphono heptanoic acid (3H-APH), a potent N-methyl-D-aspartate (NMDA) antagonist, to extensively washed, previously frozen crude mitochondrial fractions of rat brain is described. Binding was optimal at phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2e294328c23bbec3fc6572cea4857cd
https://pubmed.ncbi.nlm.nih.gov/6136884
https://pubmed.ncbi.nlm.nih.gov/6136884