Effects of depot-medroxyprogesterone acetate on the immune microenvironment of the human cervix and endometrium: implications for HIV susceptibility

Autor: Karen Smith-McCune, Ruth M. Greenblatt, Uma Shanmugasundaram, Sarah Averbach, Linda C. Giudice, Barbara L. Shacklett, Joan F. Hilton, J. W. Critchfield, Dominika Seidman

Publikováno v: Smith-McCune, KK; Hilton, JF; Shanmugasundaram, U; Critchfield, JW; Greenblatt, RM; Seidman, D; et al.(2017). Effects of depot-medroxyprogesterone acetate on the immune microenvironment of the human cervix and endometrium: Implications for HIV susceptibility. Mucosal Immunology, 10(5), 1270-1278. doi: 10.1038/mi.2016.121. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8hn2w1q5
Mucosal immunology, vol 10, iss 5
Mucosal Immunology

© 2017 Society for Mucosal Immunology. Depot-medroxyprogesterone acetate is a commonly used injectable contraceptive that has been associated with an increased risk of HIV acquisition. This study compares effects of depot-medroxyprogesterone acetate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654c8558bf32c34d2901f46de8de80b2
https://doi.org/10.1038/mi.2016.121

Predominance of weakly cytotoxic, T-bet

Autor: B E, Kiniry, A, Ganesh, J W, Critchfield, P W, Hunt, F M, Hecht, M, Somsouk, S G, Deeks, B L, Shacklett

Publikováno v: Mucosal immunology

The gastrointestinal mucosa is an important site of HIV acquisition, viral replication and pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function from their non-mucosal counterparts. Although perforin-mediated cytot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::763f1771a1c97e9e37ba7b7dc420368a
https://pubmed.ncbi.nlm.nih.gov/27827375

Mucosal T-cell responses to HIV: responding at the front lines

Autor: J. W. Critchfield, Timothy L. Hayes, Barbara L. Shacklett, April L. Ferre

Publikováno v: Journal of internal medicine. 265(1)

Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4(+) T cells that are the major cellular target for HIV infection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414676926df6e42600ebda1fd8fb3001
https://pubmed.ncbi.nlm.nih.gov/19093960

Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism

Autor: J W, Critchfield, C J, Welsh, J M, Phang, G C, Yeh

Publikováno v: Biochemical pharmacology. 48(7)

Since P-glycoprotein (P-gp) in normal tissues may serve as a cellular defense mechanism against naturally occurring xenobiotics, we considered whether physiologically active components of commonly ingested plant foods could influence P-gp function. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4fe89967c7e94b3791aa42e3874cb03
https://pubmed.ncbi.nlm.nih.gov/7945444

Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency

Autor: J. W. Critchfield, O Ho, Eric Verdin, BD Roberts, Salvatore T. Butera, C Van Lint

Publikováno v: Scopus-Elsevier

Using the OM-10.1 promyelocytic model of inducible human immunodeficiency virus type 1 (HIV-1) infection, we tested a panel of known protein kinase inhibitors for an ability to block tumour necrosis factor-α-induced HIV-1 expression. Among the compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0016ba646b308f2750c291ab10fb53
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032843282&partnerID=MN8TOARS