Zobrazeno 1 - 10
of 14
pro vyhledávání: '"J W, Cowens"'
Autor:
M, Gnant, M, Filipits, R, Greil, H, Stoeger, M, Rudas, Z, Bago-Horvath, B, Mlineritsch, W, Kwasny, M, Knauer, C, Singer, R, Jakesz, P, Dubsky, F, Fitzal, R, Bartsch, G, Steger, M, Balic, S, Ressler, J W, Cowens, J, Storhoff, S, Ferree, C, Schaper, S, Liu, C, Fesl, T O, Nielsen, Peggy, Tsang
Publikováno v:
Annals of Oncology. 25:339-345
PAM50 is a 50-gene test that is designed to identify intrinsic breast cancer subtypes and generate a Risk of Recurrence (ROR) score. It has been developed to be carried out in qualified routine hospital pathology laboratories.One thousand four hundre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5269753483edc4444907447a5af6b89
https://doi.org/10.1093/annonc/mdt494
https://doi.org/10.1093/annonc/mdt494
Autor:
J W, Cowens, P J, Creaven, W R, Greco, D E, Brenner, Y, Tung, M, Ostro, F, Pilkiewicz, R, Ginsberg, N, Petrelli
Publikováno v:
Cancer research. 53(12)
A liposome-encapsulated form of doxorubicin (TLC D-99), which was shown in preclinical toxicology to be less toxic to the gastrointestinal tract and myocardium than free doxorubicin, was administered by constant infusion (1.00-1.80 h) to 38 patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f7c850975dcf7bd86d6f361a25b8801
https://pubmed.ncbi.nlm.nih.gov/8504422
https://pubmed.ncbi.nlm.nih.gov/8504422
Autor:
P J, Creaven, J W, Cowens, D E, Brenner, B M, Dadey, T, Han, R, Huben, C, Karakousis, H, Frost, D, LeSher, J, Hanagan
Publikováno v:
Journal of biological response modifiers. 9(5)
A phase I clinical trial of the macrophage activator, muramyl tripeptide-phosphatidylethanolamine has been carried out in 37 patients (47 courses) at doses of 0.01-6.0 mg/m2 intravenously twice weekly for 4 weeks. Activation of peripheral blood monoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77e1bb29edb34f27522b2a3c8614d9bf
https://pubmed.ncbi.nlm.nih.gov/2254761
https://pubmed.ncbi.nlm.nih.gov/2254761
Autor:
Drew Watson, James Hackett, Joseph P. Costantino, Norman Wolmark, Soonmyung Paik, Kim Clark, Michael O’Connell, Greg Yothers, J. W. Cowens, Joffre B. Baker
Publikováno v:
Journal of Clinical Oncology. 24:3518-3518
3518 Background: As an initial step in developing abetter method of assessing prognosis following potentially curative surgery for colon cancer, we performed an exploratory gene identification study. Methods: RNA was extracted from three 10-micron se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e529172584b243650ac485866d8b87
https://doi.org/10.1200/jco.2006.24.18_suppl.3518
https://doi.org/10.1200/jco.2006.24.18_suppl.3518
Publikováno v:
Cancer Chemotherapy and Pharmacology. 25:15-18
Iproplatin is structurally unique among the platinum (Pt) agents in the clinic because it is a quadrivalent complex. On the basis of the redox parameters for the Pt(IV) and Pt(II) oxidation states in a chloride system, it has been suggested that Pt(I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48f18ff9e3b5cfe54af5c3a1d45907a
https://doi.org/10.1007/bf00694332
https://doi.org/10.1007/bf00694332
Publikováno v:
Journal of Liquid Chromatography. 11:793-810
Because polyamines are critically involved in the proliferation of neoplastic tissues, enzymes in their synthetic pathway present rational targets for the development of anticancer agents. AdoDATO is a potent and specific transition-state analog inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::789cf43e2887c6b74de7e12c657e61e4
https://doi.org/10.1080/01483918808068345
https://doi.org/10.1080/01483918808068345
Publikováno v:
International Journal of Mass Spectrometry and Ion Physics. 48:177-180
Cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum (IV) (CHIP) is a second generation Pt-containing complex which has completed initial clinical trial. Its proton nuclear magnetic resonance (NMR) spectrum demonstrated that the axial hydroxyl hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f628dedd00fb3a4f9ea81d22279448dd
https://doi.org/10.1016/0020-7381(83)87057-0
https://doi.org/10.1016/0020-7381(83)87057-0
Publikováno v:
The Journal of Experimental Medicine
The alkylating agent cyclophosphamide may suppress or enhance immune responses in vivo but is inactive in vitro unless metabolized by microsomal enzyme activation. 4-hydroperoxycyclophosphamide (4-HC) is a synthetic compound that is spontaneously con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5b5e32662f88890a2e28dccd40ae27
https://doi.org/10.1084/jem.155.1.276
https://doi.org/10.1084/jem.155.1.276
Autor:
J. W. Cowens, A. V. Arakali, Patrick J. Creaven, B. S. Krishnan, Lakshmi Pendyala, J. R. Walsh
Publikováno v:
Cancer Chemotherapy and Pharmacology. 25:10-14
We have previously shown that a significant portion of the total platinum in the plasma of patients receiving iproplatin is protein-bound [17]. We have also identifiedcis-dichloro-bis-isopropylamine platinum(II) (CIP) as a major metabolite of ipropla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86870c3f0b3bfb15a313ebafe4a5a1fd
https://doi.org/10.1007/bf00694331
https://doi.org/10.1007/bf00694331
Publikováno v:
Cancer chemotherapy and pharmacology. 11(1)
The pharmacokinetics of a second-generation platinum (Pt) analog cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum IV (CHIP) have been studied in 12 patients at doses from 20 to 350 mg/m2. Three Pt species have been measured: total Pt and non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4031089b3694d6f5f27fc595a130da6
https://pubmed.ncbi.nlm.nih.gov/6883623
https://pubmed.ncbi.nlm.nih.gov/6883623