Výsledky vyhledávání

N-Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats

Autor: J. W. Coffey, K. Meyers, Maja Stefanovic-Racic, R. A. Hoffman, C. Meschter, Christopher H. Evans

Publikováno v: Arthritis & Rheumatism. 37:1062-1069

Objective. To test the hypothesis that nitric oxide (NO) is involved in the pathophysiology of arthritis. Methods. Arthritis was induced in male Lewis rats by the injection of adjuvant into the base of the tail. The NO synthase (NOS) inhibitor, NG-mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08db4d9e055f4df751407f8f4f095da5
https://doi.org/10.1002/art.1780370712

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Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis

Autor: M, Stefanovic-Racic, K, Meyers, C, Meschter, J W, Coffey, R A, Hoffman, C H, Evans

Publikováno v: The Journal of rheumatology. 22(10)

To compare the nitric oxide synthase (NOS) inhibitors NG-methyl-L-arginine (L-NMA) and aminoguanidine (AG) as prophylactic and therapeutic agents in rat adjuvant induced arthritis (AIA).Arthritis was induced in male Lewis rats by the injection of adj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::649df1ae7cc5aa0ac09c4c01c8e146a1
https://pubmed.ncbi.nlm.nih.gov/8991992

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Potent peptide inhibitors of stromelysin based on the prodomain region of matrix metalloproteinases

Autor: N, Fotouhi, A, Lugo, M, Visnick, L, Lusch, R, Walsky, J W, Coffey, A C, Hanglow

Publikováno v: The Journal of biological chemistry. 269(48)

Stromelysin is secreted as an inactive zymogen that is activated in the extracellular space by cleavage of the His81-Phe82 bond with the release of the 81-amino acid propeptide domain. This segment contains a 12-amino acid sequence (MRKPRC75GVPDVG) t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b9a0d009cad15b5a9064f43a1756118
https://pubmed.ncbi.nlm.nih.gov/7982931

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Interleukin-1 beta induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. Evidence for their roles in the production of prostaglandin E2

Autor: K I, Hulkower, S J, Wertheimer, W, Levin, J W, Coffey, C M, Anderson, T, Chen, D L, DeWitt, R M, Crowl, W C, Hope, D W, Morgan

Publikováno v: Arthritis and rheumatism. 37(5)

In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::037092eb6ae1ad12362c3518f605eda9
https://pubmed.ncbi.nlm.nih.gov/8185692

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Binding of Vitamin B12-Rat Transcobalamin II and Free Vitamin B12to Plasma Membranes Isolated from Rat Liver

Autor: George R. Rowley, Christa Fiedler-Nagy, J. W. Coffey, O. N. Miller

Publikováno v: British Journal of Haematology. 31:311-321

When dialysed rat serum which contains a single, low molecular weight binder for vitamin B12, rat transcobalamin II (rat TC-II), was labelled in vitro with 57Co-vitamin B12 and then incubated at 30 degrees C (pH 7-5) with vesicles of highly purified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a7ee3700ebc1f70264a9e0dde2a981
https://doi.org/10.1111/j.1365-2141.1975.tb00862.x

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Sequential Synthesis of Two 7 S Lysins by Rats Challenged with Mouse Sarcoma-180 Tumor Cells

Autor: J. W. Coffey, Hans J. Hansen

Publikováno v: The Journal of Immunology. 96:1021-1026

Summary The administration of S-180 mouse ascites tumor cells to rats has been shown to stimulate the production of two distinct lysins capable of rupturing the tumor cells in vitro. The two antibodies were separated on diethylaminoethyl (DEAE)-cellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::143b71c78f66085544ce98feb4ec27ff
https://doi.org/10.4049/jimmunol.96.6.1021

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