Zobrazeno 1 - 10
of 107
pro vyhledávání: '"J W, Black"'
Autor:
Frans van den Berg, Malcolm Boyce, Gillian Turnbull, Sally Dowen, Duan Chen, Chun-Mei Zhao, J W Black
Publikováno v:
British Journal of Clinical Pharmacology. 79:744-755
Aims To compare gastric acid suppression by netazepide, a gastrin/CCK2 receptor antagonist, with that by a proton pump inhibitor (PPI), and to determine if netazepide can prevent the trophic effects of PPI-induced hypergastrinaemia. Methods Thirty he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8e09ca97f23a0faca0a4abcf0b2ec20
https://doi.org/10.1111/bcp.12534
https://doi.org/10.1111/bcp.12534
Publikováno v:
British Journal of Clinical Pharmacology. 76:689-698
Aims To confirm by means of pentagastrin, a synthetic gastrin agonist, that netazepide is a gastrin/CCK2 receptor antagonist in healthy subjects, and that antagonism persists during repeated dosing. Methods We did two studies in which we infused pent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a497bb7c9806473ffad8c96031a7315
https://doi.org/10.1111/bcp.12099
https://doi.org/10.1111/bcp.12099
Autor:
J W Black
Publikováno v:
British Journal of Pharmacology. 161:1204-1216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67194d2a55d9dab049ed51b45a9047fa
https://doi.org/10.1111/j.1476-5381.2010.01019.x
https://doi.org/10.1111/j.1476-5381.2010.01019.x
Autor:
J W Black
Publikováno v:
British Journal of Pharmacology. 160:S15-S25
Originally printed in Brit J Pharmacol 2010; 160 (Suppl. 1) S15–S25, doi 10.1111/j.1476-5381.2010.00848.x Please use the original publication for reference purposes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b6f81432ee00c376f391f72358bf99
https://doi.org/10.1111/j.1476-5381.2010.00848.x
https://doi.org/10.1111/j.1476-5381.2010.00848.x
Autor:
J W Black, E A Harper
Publikováno v:
British Journal of Pharmacology. 151:504-517
Background and purpose: Studies suggest that measurement of thermodynamic parameters can allow discrimination of agonists and antagonists. Here we investigate whether agonists and antagonists can be thermodynamically discriminated at histamine H3 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b3a0c9e73e1072f19e161e199ffa752
https://doi.org/10.1038/sj.bjp.0707243
https://doi.org/10.1038/sj.bjp.0707243
Publikováno v:
British Journal of Pharmacology. 151:109-124
Background and purpose: Agonist apparent affinities (pKI′) in histamine H3-receptor binding assays were higher than expected from apparent affinity values (pKapp) estimated in bioassay. Here, we investigate whether the degree of pKI′ overestimati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::847d08494ea16a8f6125ed91d2c7b902
https://doi.org/10.1038/sj.bjp.0707174
https://doi.org/10.1038/sj.bjp.0707174
Publikováno v:
British Journal of Pharmacology. 138:1358-1366
Left atrial strips from transgenic (TG4) mice with cardiac-specific overexpression (∼200-fold) of the β2 adrenoceptor (β2AR) were isolated, and their isometric force of contraction (Fc) in response to electrical stimulation was measured. The βAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f91d3517de1632bee9b77ce3268ad8
https://doi.org/10.1038/sj.bjp.0705191
https://doi.org/10.1038/sj.bjp.0705191
Publikováno v:
British Journal of Pharmacology. 129:1285-1288
The action of isoprenaline has been evaluated in an isolated, left atrial assay, from aged transgenic mice with cardiac-specific over-expression of the β2-adrenoceptor. In the assay, isoprenaline produced a negative inotropic concentration-response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb05ec4a0449c3efef18be63ed43344
https://doi.org/10.1038/sj.bjp.0703238
https://doi.org/10.1038/sj.bjp.0703238
Publikováno v:
British Journal of Pharmacology. 128:881-890
We have investigated the binding of a novel histamine H3-receptor antagonist radioligand, [3H]- clobenpropit ([3H]-VUF9153), to guinea-pig cerebral cortex membranes. Saturation isotherms for [3H]-clobenpropit appeared biphasic. Scatchard plots were c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d96477198fc4b595f44748c5b887c967
https://doi.org/10.1038/sj.bjp.0702860
https://doi.org/10.1038/sj.bjp.0702860
Publikováno v:
British Journal of Pharmacology. 128:751-759
The binding of the selective histamine H3-receptor agonist ([3H]-R-α-methylhistamine) to sites in guinea-pig cerebral cortex and ileum longitudinal muscle myenteric plexus has been characterized and a comparison made of the apparent affinities of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a373d6365118dfddb0254da7e6dfd898
https://doi.org/10.1038/sj.bjp.0702861
https://doi.org/10.1038/sj.bjp.0702861