Zobrazeno 1 - 10
of 40
pro vyhledávání: '"J W, Akkerman"'
Publikováno v:
Blood. 81:49-55
Thrombin-stimulated platelets liberate factors that induce chemotaxis of eosinophils and raise their cytosolic Ca2+ content ([Ca2+]i). The sources of this activity are the dense- and alpha-granules because inhibition of prostaglandin endoperoxide/thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda3d9a468a2605741b458fbe675e240
https://doi.org/10.1182/blood.v81.1.49.bloodjournal81149
https://doi.org/10.1182/blood.v81.1.49.bloodjournal81149
Publikováno v:
European journal of biochemistry. 267(24)
Human platelets contain a Na+/H+ exchanger (NHE) that regulates the cytosolic pH. The role of trimeric G-proteins in NHE control was investigated in plasma membrane vesicles by measuring exchange of intravesicular protons for extravesicular Na+. Exch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6d48a5298d2565673840d8fc871dfb1
https://pubmed.ncbi.nlm.nih.gov/11106421
https://pubmed.ncbi.nlm.nih.gov/11106421
Publikováno v:
The Biochemical journal. 349(Pt 1)
Physiological concentrations of low-density lipoprotein (LDL) sensitize blood platelets to alpha-thrombin- and collagen-induced secretion, and after prolonged contact trigger secretion independent of other agonists. Here we report that LDL activates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::207f4e69ed96b55f60e23072faf4e079
https://pubmed.ncbi.nlm.nih.gov/10861233
https://pubmed.ncbi.nlm.nih.gov/10861233
Publikováno v:
Thrombosis and haemostasis. 83(4)
Thrombopoietin (TPO) regulates stem cell proliferation and maturation of megakaryocytes by activating the c-Mp1-receptor, a member of the hematopoietic cytokine family. As human platelets possess c-Mp1-receptors and supraphysiological concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e05bcd2eeea0e6df05147ed9a7b3799
https://pubmed.ncbi.nlm.nih.gov/10780326
https://pubmed.ncbi.nlm.nih.gov/10780326
Publikováno v:
Thrombosis and haemostasis. 82(6)
Low Density Lipoprotein (LDL) is known to sensitize platelets for physiological agonists. To clarify the basis of this sensitization, we investigated the involvement of p38MAP Kinase (p38MAPK). As dual phosphorylation on Thr180 and Tyr182 of p38MAPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24f8281c5ae4b954304615f97d37ea00
https://pubmed.ncbi.nlm.nih.gov/10613665
https://pubmed.ncbi.nlm.nih.gov/10613665
Publikováno v:
Thrombosis and haemostasis. 79(5)
In platelets and megakaryoblasts Gs, the trimeric G-protein that stimulates adenylyl cyclase, is present in a short, 45 kDa, and a long, 52 kDa isoform termed G(s)alpha-S and G(s)alpha-L, respectively. To assess the relative contribution of these iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bf0051d90b14e239e7b2af1a2c9943c
https://pubmed.ncbi.nlm.nih.gov/9609239
https://pubmed.ncbi.nlm.nih.gov/9609239
Autor:
A, Schootemeijer, G, van Willigen, H, van der Vuurst, L G, Tertoolen, S W, De Laat, J W, Akkerman
Publikováno v:
Thrombosis and haemostasis. 77(1)
The migration of integrins to sites of cell-cell and cell-matrix contact is thought to be important for adhesion strengthening. We studied the lateral diffusion of integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) in the plasma membrane of a cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf1cf0af6626d5a04f1faafe2619c40f
https://pubmed.ncbi.nlm.nih.gov/9031465
https://pubmed.ncbi.nlm.nih.gov/9031465
Publikováno v:
Thrombosis and haemostasis. 74(4)
The possibility to induce specific disruption of activated platelets by binding of porcine pancreatic phospholipase A2 (PLA2) was tested by constructing a set of PLA2-mutants containing an Arg-Gly-Asp (RGD) sequence. One mutant was made with RGD as p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03b7057fd8ef5f60abd665036b2ddfc8
https://pubmed.ncbi.nlm.nih.gov/8560426
https://pubmed.ncbi.nlm.nih.gov/8560426
Publikováno v:
European journal of clinical nutrition. 49(5)
It has been suggested that certain foods of plant origin contain milligram-quantities of acetylsalicylate which could exert an anti-thrombotic effect. Acetylsalicylic acid prevents cardiovascular diseases through inhibition of platelet endoperoxide t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f81631f210174b218dfc3d7c0d96613
https://pubmed.ncbi.nlm.nih.gov/7664723
https://pubmed.ncbi.nlm.nih.gov/7664723
Publikováno v:
Journal of lipid mediators. 7(2)
The administration of platelet-activating factor (PAF) to human subjects triggers asthma-like responses. We investigated whether a bronchoconstrictive reaction was accompanied by the release of PAF in the circulation of allergic asthmatics. The appea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fbdf1d00ee79794218525c9861ff0c7
https://pubmed.ncbi.nlm.nih.gov/8400115
https://pubmed.ncbi.nlm.nih.gov/8400115