Zobrazeno 1 - 10
of 10
pro vyhledávání: '"J Victor Swain"'
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66065 (2013)
The recently available x-ray crystal structure of HIV-1 capsid hexamers has provided insight into the molecular interactions crucial for the virus's mature capsid formation. Amino acid changes at these interaction points are likely to have a strong i
Externí odkaz:
https://doaj.org/article/9e4f0c6a51f943ebabd5df1c62056ac3
Autor:
Jonathan C. Reed, Kent Matlack, Daryl J. Phuong, J. Victor Swain, Clarence R. Hurt, Beverly Freeman, Jaisri R. Lingappa, Dennis Solas, Dylan T. B. Ressler, Anatoliy Kitaygorodskyy, Vishwanath R. Lingappa
Publikováno v:
Journal of Virology
The success of antiretroviral treatment for HIV-1 is at risk of being undermined by the growing problem of drug resistance. Thus, there is a need to identify antiretrovirals that act on viral life cycle stages not targeted by drugs in use, such as th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118b8004f0c4b477c1eb1e90f47fd9d7
https://pubmed.ncbi.nlm.nih.gov/33148797
https://pubmed.ncbi.nlm.nih.gov/33148797
Autor:
Morgane Rolland, Jonathan M Carlson, Siriphan Manocheewa, J Victor Swain, Erinn Lanxon-Cookson, Wenjie Deng, Christine M Rousseau, Dana N Raugi, Gerald H Learn, Brandon S Maust, Hoosen Coovadia, Thumbi Ndung'u, Philip J R Goulder, Bruce D Walker, Christian Brander, David E Heckerman, James I Mullins
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (C
Externí odkaz:
https://doaj.org/article/f4df0c7bf2524d97bd249e82a543bae6
Autor:
J. Victor Swain, Brandon S. Maust, J. Sunshine, Jan McClure, Siriphan Manocheewa, Yi Liu, Moon S. Kim, Erinn Lanxon-Cookson, Morgane Rolland, Ushnal Rao, Wenjie Deng, James I. Mullins
Publikováno v:
Journal of Visualized Experiments : JoVE
In vitro fitness assays are essential tools for determining viral replication fitness for viruses such as HIV-1. Various measurements have been used to extrapolate viral replication fitness, ranging from the number of viral particles per infectious u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501d5eab4ed0059cd91d2953439797eb
https://doi.org/10.3791/52610-v
https://doi.org/10.3791/52610-v
During HIV-1 assembly, Gag polypeptides target to the plasma membrane, where they multimerize to form immature capsids that undergo budding and maturation. Previous mutational analyses identified residues within the Gag matrix (MA) and capsid (CA) do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2522ca39674d350f6550ca95edb988
https://europepmc.org/articles/PMC4019110/
https://europepmc.org/articles/PMC4019110/
Autor:
Dylan H. Westfall, James I. Mullins, Robert A. Smith, Moon S. Kim, J. Victor Swain, Siriphan Manocheewa, Brandon S. Maust, Erinn Lanxon-Cookson, Morgane Rolland
Publikováno v:
Journal of virological methods. 194(1-2)
Cell culture growth competition assays of human immunodeficiency virus type 1 (HIV-1) are used to estimate viral fitness and quantify the impact of mutations conferring drug resistance and immunological escape. A comprehensive study of growth competi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c4f2aa6ca1e34cf4701b5365eb8130
https://pubmed.ncbi.nlm.nih.gov/23933395
https://pubmed.ncbi.nlm.nih.gov/23933395
Autor:
J. Victor Swain, Erinn Lanxon-Cookson, Sarah Holte, Yi Liu, Lennie Chen, James I. Mullins, Moon S. Kim, Ushnal Rao, Philip Konopa, Jan McClure
Publikováno v:
Journal of virological methods. 189(1)
Fixation of mutations in human immunodeficiency virus type 1 (HIV-1), such as those conferring drug resistance and immune escape, can result in a change in replication fitness. To assess these changes, a real-time TaqMan PCR detection assay and stati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530bf8abba1db979491199d11b78b9c5
https://pubmed.ncbi.nlm.nih.gov/23201292
https://pubmed.ncbi.nlm.nih.gov/23201292
Autor:
Wenjie Deng, James I. Mullins, Christine Rousseau, J. Victor Swain, Siriphan Manocheewa, Erinn Lanxon-Cookson, Jonathan M. Carlson, Gerald H. Learn, Morgane Rolland, Thumbi Ndung'u, Philip J. R. Goulder, David Heckerman, Bruce D. Walker, Brandon S. Maust, Christian Brander, Hoosen M. Coovadia, Dana N. Raugi
Publikováno v:
PLoS ONE
PLoS
PLoS ONE, Vol 5, Iss 9 (2010)
PLoS
PLoS ONE, Vol 5, Iss 9 (2010)
Background Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a785546c6610b3c518836b478b6a9909
http://europepmc.org/articles/PMC2931691
http://europepmc.org/articles/PMC2931691
Autor:
Ushnal Rao, Michael Schindler, Frank Kirchhoff, Angélique B. van 't Wout, J. Victor Swain, James I. Mullins, Melissa S. Pathmajeyan
Publikováno v:
Journal of virology, 79(15), 10053-10058. American Society for Microbiology
Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays. HIV-1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7924ff2c85e5f7d56d0d23129b3587
https://pure.amc.nl/en/publications/nef-induces-multiple-genes-involved-in-cholesterol-synthesis-and-uptake-in-human-immunodeficiency-virus-type-1infected-t-cells(4b777c92-971c-4b25-b8d9-f9385bf28feb).html
https://pure.amc.nl/en/publications/nef-induces-multiple-genes-involved-in-cholesterol-synthesis-and-uptake-in-human-immunodeficiency-virus-type-1infected-t-cells(4b777c92-971c-4b25-b8d9-f9385bf28feb).html
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