Výsledky vyhledávání - "J Vanoirbeek"

Akademický článek

Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome.

Autor: Emilie Pollenus, Hendrik Possemiers, Sofie Knoops, Fran Prenen, Leen Vandermosten, Chloë Thienpont, Saeed Abdurahiman, Sofie Demeyer, Jan Cools, Gianluca Matteoli, Jeroen A J Vanoirbeek, Greetje Vande Velde, Philippe E Van den Steen

Publikováno v: PLoS Pathogens, Vol 20, Iss 1, p e1011929 (2024)

Plasmodium parasites cause malaria, a global health disease that is responsible for more than 200 million clinical cases and 600 000 deaths each year. Most deaths are caused by various complications, including malaria-associated acute respiratory dis

Externí odkaz: https://doaj.org/article/e58f5cf4cbf44278908ea85b13b37555

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Akademický článek

Impact of a Polymer-Based Nanoparticle with Formoterol Drug as Nanocarrier System In Vitro and in an Experimental Asthmatic Model

Autor: Buket Bakan, Anne-Charlotte Jonckheere, Tatjana Decaesteker, Nora F. Marain, Sivakumar Murugadoss, Nefise Ulku Karabay Yavasoglu, Umut Şahar, Raziye Hilal Şenay, Sinan Akgöl, Özlem Göksel, Peter H. M. Hoet, Jeroen A. J. Vanoirbeek

Publikováno v: Toxics, Vol 11, Iss 12, p 974 (2023)

The implementation of nanotechnology in pulmonary delivery systems might result in better and more specific therapy. Therefore, a nano-sized drug carrier should be toxicologically inert and not induce adverse effects. We aimed to investigate the resp

Externí odkaz: https://doaj.org/article/c215a109da2b48d0a31042d84771bff8

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Peribronchial Inflammation Resulting from Regulatory T Cell Deficiency Damages the Respiratory Epithelium and Disturbs Barrier Function

Autor: Anne-Charlotte Jonckheere, Brecht Steelant, Sven F. Seys, Jonathan Cremer, Ellen Dilissen, Louis Boon, Adrian Liston, Rik Schrijvers, Christine Breynaert, Jeroen A. J. Vanoirbeek, Jan L. Ceuppens, Dominique M. A. Bullens

Publikováno v: The Journal of Immunology. 209:1595-1605

Regulatory T cells (Tregs) that express the transcription factor Foxp3 have a critical role in limiting inflammatory processes and tissue damage. Whether Tregs are functional in maintaining epithelial barriers and in control of tight junction express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252e1fca3e429c5370cead149acb6b8e
https://doi.org/10.4049/jimmunol.2200416

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Akademický článek

TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

Autor: Yeranddy A. Alpizar, Brett Boonen, Alicia Sanchez, Carole Jung, Alejandro López-Requena, Robbe Naert, Brecht Steelant, Katrien Luyts, Cristina Plata, Vanessa De Vooght, Jeroen A. J. Vanoirbeek, Victor M. Meseguer, Thomas Voets, Julio L. Alvarez, Peter W. Hellings, Peter H. M. Hoet, Benoit Nemery, Miguel A. Valverde, Karel Talavera

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide p

Externí odkaz: https://doaj.org/article/305c11c87f63412e9d5471df82642beb

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Akademický článek

Effect of Graphene and Graphene Oxide on Airway Barrier and Differential Phosphorylation of Proteins in Tight and Adherens Junction Pathways

Autor: Sofie Van Den Broucke, Jeroen A. J. Vanoirbeek, Rita Derua, Peter H. M. Hoet, Manosij Ghosh

Publikováno v: Nanomaterials, Vol 11, Iss 5, p 1283 (2021)

Via inhalation we are continuously exposed to environmental and occupational irritants which can induce adverse health effects, such as irritant-induced asthma (IIA). The airway epithelium forms the first barrier encountered by these agents. We inves

Externí odkaz: https://doaj.org/article/03932e48a8ed4e319f3a1f82b25c3b88

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Akademický článek

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