Zobrazeno 1 - 10 of 65 pro vyhledávání: '"J V Watson"'
1
Multivariate analyses of DNA index, p62c-myc, and clinicopathological status of patients with ovarian cancer
Autor: M Curling, J V Watson, C N Hudson, S Stenning
Publikováno v: Journal of Clinical Pathology. 51:455-461
AIM: To determine if either DNA index or p62c-myc is an independent prognostic variable in ovarian cancer. METHODS: Multivariate and univariate analyses of the relation between DNA index, p62c-myc, FIGO stage, histological type, tumour grade, complet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dcebcd4e6120c9577c1dae9d45e769
https://doi.org/10.1136/jcp.51.6.455
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2
Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells
Autor: Norman M. Bleehen, Paul Smith, S. Souès, J. V. Watson, S.J. Falk, R.J. Osborne, T. Gottlieb
Publikováno v: British Journal of Cancer
As an approach to the rational design of combination chemotherapy involving the anti-cancer DNA topoisomerase II poison etoposide (VP-16), we have studied the dynamic changes occurring in small-cell lung cancer (SCLC) cell populations during protract
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36d6505d8aa84fdf5db986b405fad2b
https://doi.org/10.1038/bjc.1994.420
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4
c-myc protein product is a marker of DNA synthesis but not of malignancy in human gastrointestinal tissues and tumours
Autor: H. Cox, George S. Wilson, J. V. Watson, David A. Rew, I. Taylor
Publikováno v: British Journal of Surgery. 78:1080-1083
c-myc is a conserved cellular gene. The gene product is a nuclear-bound 62000 molecular weight phosphoprotein (p62c-myc). Although p62c-myc levels have been measured in colorectal cancers, little is known about the expression of the protein in upper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55ce3f9bc8d7774ef1a5100f104979c
https://doi.org/10.1002/bjs.1800780916
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5
Reduced nuclear binding of a DNA minor groove ligand (Hoechst 33342) and its impact on cytotoxicity in drug resistant murine cell lines
Autor: S A Morgan, J V Watson, Paul Smith, P R Twentyman
Publikováno v: British Journal of Cancer
The reduced cellular uptake, and subsequent reduced nuclear availability, of cytotoxic agents is a factor in the resistance of mammalian cells to anti-cancer drugs that act by interaction with DNA. The whole cell uptake, nuclear binding and cytotoxic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e90b651f48e3b00081713efca07581
https://doi.org/10.1038/bjc.1990.417
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6
Caffeine overcomes a restriction point associated with DNA replication, but does not accelerate mitosis
Autor: S. R. R. Musk, J. V. Watson, C. S. Downes, Robert T. Johnson
Publikováno v: The Journal of Cell Biology
Mitotic chromosome condensation is normally dependent on the previous completion of replication. Caffeine spectacularly deranges cell cycle controls after DNA polymerase inhibition or DNA damage; it induces the condensation, in cells that have not co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8814a475caac77816cf54a461eaa9357
http://europepmc.org/articles/PMC2116112
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7
A brief history of numbers and statistics with cytometric applications
Autor: J V, Watson
Publikováno v: Cytometry. 46(1)
A brief history of numbers and statistics traces the development of numbers from prehistory to completion of our current system of numeration with the introduction of the decimal fraction by Viete, Stevin, Burgi, and Galileo at the turn of the 16th c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9209dd79ada78137cce900c88ae781fd
https://pubmed.ncbi.nlm.nih.gov/11241502
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8
Proof without prejudice revisited: immunofluorescence histogram analysis using cumulative frequency subtraction plus ratio analysis of means
Autor: J V, Watson
Publikováno v: Cytometry. 43(1)
Apart from the work of Lampariello and colleagues (Cytometry 15:294-301, 1994; Cytometry 32:241-254, 1998), very little analytical work has been carried out for analysis of immunofluorescence distributions containing an overlapping mixture of labeled
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5712a5dd060be5d0edf602ea4e46376
https://pubmed.ncbi.nlm.nih.gov/11122485
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9
Characteristics of a novel deep red/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopy
Autor: P J, Smith, N, Blunt, M, Wiltshire, T, Hoy, P, Teesdale-Spittle, M R, Craven, J V, Watson, W B, Amos, R J, Errington, L H, Patterson
Publikováno v: Cytometry. 40(4)
The multiparameter fluorometric analysis of intact and fixed cells often requires the use of a nuclear DNA discrimination signal with spectral separation from visible range fluorochromes. We have developed a novel deep red fluorescing bisalkylaminoan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cbcbfe69b2e2e51a2dd12d14eabf499
https://pubmed.ncbi.nlm.nih.gov/10918279
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10
The early fluidic and optical physics of cytometry
Autor: J V, Watson
Publikováno v: Cytometry. 38(1)
All forms of cytometry, depend on the basic laws of physics, including those of fluidics, optics, and electronics, most of which were established centuries ago. Flow cytometry depends critically on the fluidics presenting each individual cell with pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7a1577a1d46a54d96b4c23a97dd68b9
https://pubmed.ncbi.nlm.nih.gov/10088971
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