Zobrazeno 1 - 10
of 353
pro vyhledávání: '"J Tweedie"'
Autor:
Amitouj S. Sidhu, Charles E.L. Walker, Thomas D. Riisfeldt, Peter J. Tweedie, Natasha Gerbis, Emily J. Sutherland, Neil G. Simon, Lucy K. Somerville, Ross Bradbury, Raymond Cook, Jonathon Parkinson, Robert Goetti, Ian C. Francis
Publikováno v:
Case Reports in Ophthalmology, Vol 15, Iss 1, Pp 423-429 (2024)
Introduction: Streptococcal meningoencephalitis (SME) is a rare, and frequently lethal, acute infection, and inflammation of the central nervous system parenchyma, with associated meningeal involvement. Bacterial meningoencephalitis is generally asso
Externí odkaz:
https://doaj.org/article/a51f405c1d604905927d4939a6d218f9
Akademický článek
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Akademický článek
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Publikováno v:
Moderated poster session 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e7b951753c65a76e85c48d5ab34adbf
https://doi.org/10.1136/heartjnl-2022-ics.26
https://doi.org/10.1136/heartjnl-2022-ics.26
Autor:
Heidi J. Einolf, Barry Jones, Phillip D. Yates, Theunis C. Goosen, Diane Ramsden, Conrad Fung, Y. Amy Siu, Niresh Hariparsad, Simon Wong, Liangfu Chen, Jairam Palamanda, George Zhang, Donald J. Tweedie, Shannon Dallas
Publikováno v:
Drug Metabolism and Disposition. 49:94-110
Translational and ADME Sciences Leadership Group Induction Working Group (IWG) presents an analysis on the time course for cytochrome P450 induction in primary human hepatocytes. Induction of CYP1A2, CYP2B6, and CYP3A4 was evaluated by seven IWG labo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa020936133a247e86ba65e02dc01b76
https://doi.org/10.1124/dmd.120.000055
https://doi.org/10.1124/dmd.120.000055
Autor:
Alvaro Ramirez, Jerry Y. Y. Heng, Massimo Poletto, Sebastian Maass, Steve W. Smith, Richard J. Tweedie, Christophe Bressot, Martin Morgeneyer
Publikováno v:
Chemical Engineering Research and Design. 146:162-165
"Can particle technology, in spite of its multiplicity, be regarded, and scientifically taught, as a uniform discipline?" wondered H. Rumpf, one of the founding fathers of particle science, in a programmatic speech which he gave 40 years ago. Given h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8d03270ffd33a5ac688305e55ac23e
https://doi.org/10.1016/j.cherd.2018.11.029
https://doi.org/10.1016/j.cherd.2018.11.029
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(11)
Recognizing the challenges of determining the relative contribution of different drug metabolizing enzymes to the metabolism of slowly metabolized compounds, a cytochrome P450 reaction phenotyping (CRP) method using cocultured human hepatocytes (HEPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0947ba45d4662d8ceb71fc0fcc46cfd
https://pubmed.ncbi.nlm.nih.gov/34407991
https://pubmed.ncbi.nlm.nih.gov/34407991
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615539
An appreciation of enzyme kinetic principles can be applied in a number of drug metabolism applications. The concept for this chapter arose from a simple discussion on selecting appropriate time points to most efficiently assess metabolite profiles i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2d66291d82c9a1a7a8257d0888623d8
https://doi.org/10.1007/978-1-0716-1554-6_23
https://doi.org/10.1007/978-1-0716-1554-6_23
Autor:
Vicki Sutherland, Sangeeta Khare, Steven Foley, Xue Liang, Connie S. Chen, Alexander V. Alekseyenko, José E. Manautou, Howard Young, Frank Burns, Alan Wilson, Charlene A. McQueen, Sam Forry, Donna L. Mendrick, Donald J. Tweedie, Carl Cerniglia, Rod Dietert, Donna Gulezian
Publikováno v:
Toxicol Sci
There is an increasing awareness that the gut microbiome plays a critical role in human health and disease, but mechanistic insights are often lacking. In June 2018, the Health and Environmental Sciences Institute (HESI) held a workshop, “The Gut M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b552e9ad4aa035da554a05fecbc882
https://pubmed.ncbi.nlm.nih.gov/32658296
https://pubmed.ncbi.nlm.nih.gov/32658296
Autor:
Donald J. Tweedie, Raymond Evers, Zufei Zhang, Erina Paul, Andrew H. Latham, Anne Gillespie, Kate Mostoller, Xiaoyan Chu, Ted Marenco, Aparna Chhibber, Matthew Murphy, Jianzhong Wen, Kenneth C. Lasseter, Nadia Cardillo Marricco, Patrick Larson, Daniel Tatosian, Michael E. Lassman, Jianmei Pang, Tami Crumley, Santosh C. Sutradhar, Ya-Juan Wang, S. Aubrey Stoch, Thomas Marbury, Ka Lai Yee
Publikováno v:
Clinical pharmacology and therapeutics. 109(2)
Renal impairment (RI) is known to influence the pharmacokinetics of nonrenally eliminated drugs, although the mechanism and clinical impact is poorly understood. We assessed the impact of RI and single dose oral rifampin (RIF) on the pharmacokinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429ead40ccf450a9ab36c0ba9d98b60a
https://pubmed.ncbi.nlm.nih.gov/32705692
https://pubmed.ncbi.nlm.nih.gov/32705692