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Akademický článek

IMPACT OF NLRP3 INFLAMMASOME ON THE DEVELOPMENT OF HYPERTENSION AND RENAL AND CARDIAC HYPERTROPHY IN 2K1C AND DOCA/SALT MICE

Autor: Q. Wang, A So, J. Nussberger, J. Tschopp, M. Burnier

Publikováno v: Kidney Research and Clinical Practice, Vol 31, Iss 2, p A83 (2012)

NLRP3 inflammasome is formed by NLRP3, the adaptor ASC, and caspase-1, functions as a sensor of danger signals and triggers processing and release of interleukin-1beta (IL-1β). Recent animal studies demonstrate that NLRP3 inflammasome promotes renal

Externí odkaz: https://doaj.org/article/98dfb5f96f7c4bee855b38d3c4f02593

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Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling

Autor: Pierre J. Magistretti, Igor Allaman, Nicole Schaeren-Wiemers, Melanie Gentner, J. Tschopp, Thomas Zeis, Kate Schroder

Publikováno v: Brain Behavior and Immunity
Brain behavior and immunity
Brain, Behavior, and Immunity, vol. 48, pp. 313-325

Emerging as an important correlate of neurological dysfunction in Multiple Sclerosis (MS), extended focal and diffuse gray matter abnormalities have been found and linked to clinical manifestations such as seizures, fatigue and cognitive dysfunction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4564e8745efac7fd001abb08a1b033ae

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The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade

Autor: Kate Schroder, Manuele Rebsamen, Leonhard X. Heinz, J. Tschopp, Pascal Schneider, Olaf Gross, Manfredo Quadroni, Francesco Staehli, D C Rossi

Publikováno v: CELL DEATH AND DIFFERENTIATION

The family of death domain (DD)-containing proteins are involved in many cellular processes, including apoptosis, inflammation and development. One of these molecules, the adapter protein MyD88, is a key factor in innate and adaptive immunity that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7206df5a298e922d573fabbdacb445
https://doi.org/10.1038/cdd.2011.147

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Th17 (PP-014)

Autor: A. E. Hauser, H. Wu, E. Esplugues, M. Tsuruoka, W. Niedbala, J. Elia, S. Tsuyoshi, B. Cai, V. Flamand, S. Iwamoto, M. Hirashima, S. Tanaka, H. L. Qian, H. Kai, C. Yu, A. Yoshimura, A. Yamauchi, J. Masuyama, Y. Kang, J. M. Wilson, J. Rohrer, T. Tanaka, M. Weinstein, F. Tsuji, D. Chuang, Y. Xiao, S. Yamada, E. A. M. Veraar, S. Wu, Yoh-ichi Tagawa, T. Kamiyama, S. M. Vieira, M. Tajima, S. Huber, J. C. Alves-Filho, F. Suzuki, J. Rabenstein, M. Kadowaki, K. Masuko, C. Liu, I. Debock, S. Oomizu, A. Chu, H. Aono, J. Kang, J. Lastovicka, K. Ishihara, A. Sediva, T. Arikawa, N. Malhotra, S. Miuznoe, B. Oh, X. Wang, F. Zhu, H. Yasuhara, J. M. Coquet, S. Lee, I. Matumoto, D. Wakita, T. Koga, Katsuko Sudo, K. Matsushima, S. Saijo, F. Q. Cunha, U. A. K. Betz, A. Ikejiri, H. Park, S. Y. Fukada, J. Yoon, H. Uga, O. Beretta, D. Noguchi, C. Chu, M. Roecken, H. Sepulveda, B. A. Wu-Hsieh, T. Matsuda, T. Okazawa, S. Kim, H. Hirota, H. Kitamura, Y. Liu, D. N. Herndon, T. Town, F. Liu, A. Yazdi, T. Niki, H. Lee, C. Deng, M. Kono, S. Feske, N. Ueda, R. Horvath, T. Sumida, G. Licandro, T. Nishimura, M. Harada, S. Koyasu, P. B. Ernst, M. Murakami, T. Sato, M. Suico, S. Black, M. Kanayama, Kazuo Sugane, C. Kitabayashi, K. Ghoreschi, C. Matsumoto, R. A. Flavell, T. Atsumi, M. G. Jeschke, E. A. O'Donnell, M. Nishihara, J. Borst, M. Kobayashi, Z. Lining, R. Spreafico, J. Morimoto, H. Ogura, A. Haberman, T. Kaisho, M. Pétein, N. Gagliani, T. Fukada, A. Miyazaki, J. Tschopp, G. van der Horst, J. Soh, S. Park, Yoichiroh Iwakura, T. Hu, S. Delbauve, Q. Wang, J. Ma, D. C. Gruenert, A. Mitani, Y. Miyamoto, S. Ikeda, P. Ricciardi-Castagnoli, S. Iwai, H. Watanabe, E. Huseby, T. Uede, S. Suzuki, C. McCarl, S. Hida, K. Ichiyama, I. Glocova, I. Azuma, S. Hojyo, K. Oguchi, F. Y. Liew, A. Mortellaro, J. Yu, M. Goldman, S. Nakae, A. Polouckova, J. Brueck, W. Ohashi, R. Spisek, M. Ikeda, T. Hirano, A. Inatsu, O. Kim, C. Conforti-Andreoni, M. Yanagida, S. Khalil, Masaya Takamoto, M. Festing, M. Mamura, S. Miaw, H. Kurata, M. Kanamoto, S. Nagai, U. Ikeda

Publikováno v: International Immunology. 22:i96-i101

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88215d3af015208cab10445f1625ca06
https://doi.org/10.1093/intimm/dxq101

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Akademický článek

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Autor: J. Tschopp, Fabio Martinon, Virginie Pétrilli, Annick Mayor, Papin S, Catherine Dostert

Publikováno v: Cell Death & Differentiation. 14:1583-1589

Inflammasomes are Nod-like receptor(NLR)- and caspase-1-containing cytoplasmic multiprotein complexes, which upon their assembly, process and activate the proinflammatory cytokines interleukin (IL)-1beta and IL-18. The inflammasomes harboring the NLR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9620478eaa16270aae61799fc36d441d
https://doi.org/10.1038/sj.cdd.4402195

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[Loco-regional complications of pharyngitis: the example of Lemierre's syndrome]

Autor: J, Tschopp, C, Chuard

Publikováno v: Revue medicale suisse. 11(489)

Pharyngitis is a common cause of consultation in ambulatory medicine. Although it is benign in most cases, serious complications may happen and must be recognized quickly. Lemierre's syndrome is one of them. It consists in the association of thrombos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5544e88b1a8a1ceb40fff8c88477b8b5
https://pubmed.ncbi.nlm.nih.gov/26638515

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Inflammatory caspases and inflammasomes: master switches of inflammation

Autor: Fabio Martinon, J. Tschopp

Publikováno v: Cell Death & Differentiation. 14:10-22

Fifteen years have passed since the cloning and characterization of the interleukin-1beta-converting enzyme (ICE/caspase-1), the first identified member of a family of proteases currently known as caspases. Caspase-1 is the prototypical member of a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee0881151fd4b8ab974ae050638573f
https://doi.org/10.1038/sj.cdd.4402038

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