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Detection of T helper responses, but not of human papillomavirus-specific cytotoxic T lymphocyte responses, after peptide vaccination of patients with cervical carcinoma

Autor: Thomas Bauknecht, R. M. P. Brandt, J.H. de Jong, W. M. Kast, R Offringa, G J Fleuren, Maaike E. Ressing, Cornelis J. M. Melief, W.J. van Driel, Gemma G. Kenter, Howard M. Grey, P Hoogerhout, A Sette, Esteban Celis, B J Trimbos

Publikováno v: Journal of immunotherapy (Hagerstown, Md., 23(2), 255-266. Lippincott Williams and Wilkins

Human papillomavirus type 16 (HPV16)-encoded E7 oncoprotein is constitutively expressed in cervical carcinoma cells and is required for cellular transformation to be maintained. The E7 protein, therefore, forms an attractive target for T-cell-mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6909c3fe54e56420b185e40a4582fb
https://doi.org/10.1097/00002371-200003000-00010

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Treatment of patients with early epithelial ovarian cancer

Autor: Ignace Vergote, Baptist J Trimbos

Publikováno v: Current opinion in oncology. 15(6)

Purpose of review During 2003, the first randomized trials were published comparing adjuvant platin-based chemotherapy versus no treatment in early epithelial ovarian cancer. Recent findings Recent findings of the European Organisation for Research a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5c407255af3a5d61e1c8b66fc42221
https://pubmed.ncbi.nlm.nih.gov/14624228

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Occasional memory cytotoxic T-cell responses of patients with human papillomavirus type 16-positive cervical lesions against a human leukocyte antigen-A *0201-restricted E7-encoded epitope

Autor: M E, Ressing, W J, van Driel, E, Celis, A, Sette, M P, Brandt, M, Hartman, J D, Anholts, G M, Schreuder, W B, ter Harmsel, G J, Fleuren, B J, Trimbos, W M, Kast, C J, Melief

Publikováno v: Cancer research. 56(3)

Most cervical carcinoma (Cxca) cells constitutively express human papillomavirus type 16 (HPV16) E6 and E7 oncoproteins. These proteins are, therefore, attractive targets for T cell-based immunotherapy. Previously, we identified HVP16 E7-encoded CTL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2572a8fe809ca684f9f21ab93ed5980c
https://pubmed.ncbi.nlm.nih.gov/8564975

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