Zobrazeno 1 - 10
of 369
pro vyhledávání: '"J Topham"'
Autor:
William Bender, Yun Zhang, Anthony Corbett, Chinyi Chu, Alexander Grier, Lu Wang, Xing Qiu, Matthew N. McCall, David J. Topham, Edward E. Walsh, Thomas J. Mariani, Richard Scheuermann, Mary T. Caserta, Christopher S. Anderson
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Background Respiratory Syncytial Virus (RSV) disease in young children ranges from mild cold symptoms to severe symptoms that require hospitalization and sometimes result in death. Studies have shown a statistical association between RSV sub
Externí odkaz:
https://doaj.org/article/a0b3c7fe825e4a1da8efbb317d451f0c
Autor:
Michael Piepenbrink, Fatai Oladunni, Aitor Nogales, Ahmed M. Khalil, Theresa Fitzgerald, Thomas A. Hilimire, Madhubanti Basu, Christopher Fucile, David J. Topham, Alexander F. Rosenberg, Luis Martinez-Sobrido, James J. Kobie
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/3c461e3578174133b041510e0c25377b
Autor:
Michael Piepenbrink, Fatai Oladunni, Aitor Nogales, Ahmed M. Khalil, Theresa Fitzgerald, Madhubanti Basu, Christopher Fucile, David J. Topham, Alexander F. Rosenberg, Luis Martinez-Sobrido, James J. Kobie
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Due to antigenic drift and shift of influenza A viruses (IAV) and the tendency to elicit predominantly strain-specific antibodies, humanity remains susceptible to new strains of seasonal IAV and is at risk from viruses with pandemic potentia
Externí odkaz:
https://doaj.org/article/ebdd68412b794cc08dc6d57fed2668bf
Autor:
Laura Villamayor, Vanessa Rivero, Darío López-García, David J. Topham, Luis Martínez-Sobrido, Aitor Nogales, Marta L. DeDiego
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interferons (IFNs), IFN-stimulated genes (ISGs), and inflammatory cytokines mediate innate immune responses, and are essential to establish an antiviral response. Within the innate immune responses, retinoic acid-inducible gene I (RIG-I) is a key sen
Externí odkaz:
https://doaj.org/article/0f399e85632a43d59aa5e03c07e0ff83
Airway gene-expression classifiers for respiratory syncytial virus (RSV) disease severity in infants
Autor:
Lu Wang, Chin-Yi Chu, Matthew N. McCall, Christopher Slaunwhite, Jeanne Holden-Wiltse, Anthony Corbett, Ann R. Falsey, David J. Topham, Mary T. Caserta, Thomas J. Mariani, Edward E. Walsh, Xing Qiu
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021)
Abstract Background A substantial number of infants infected with RSV develop severe symptoms requiring hospitalization. We currently lack accurate biomarkers that are associated with severe illness. Method We defined airway gene expression profiles
Externí odkaz:
https://doaj.org/article/45e1b0f2041844a9b6b9200b402a3534
Autor:
Andrew McDavid, Nathan Laniewski, Alex Grier, Ann L. Gill, Haeja A. Kessler, Heidie Huyck, Elizabeth Carbonell, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Jennifer Carnahan, Andrew M. Dylag, David J. Topham, Ann R. Falsey, Mary T. Caserta, Gloria S. Pryhuber, Steven R. Gill, Kristin M. Scheible
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104007- (2022)
Summary: Neonatal immune-microbiota co-development is poorly understood, yet age-appropriate recognition of – and response to – pathogens and commensal microbiota is critical to health. In this longitudinal study of 148 preterm and 119 full-term
Externí odkaz:
https://doaj.org/article/dc890ebcbe60431d83a0f7f363235879
Autor:
Sigrid Gouma, Kangchon Kim, Madison E. Weirick, Megan E. Gumina, Angela Branche, David J. Topham, Emily T. Martin, Arnold S. Monto, Sarah Cobey, Scott E. Hensley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Influenza exposure in early childhood can affect the immune response to distinct viral strains later in life. Here, Gouma et al. show that contemporary 3c2.A H3N2 virus infections boost non-neutralizing H3N2 antibodies in middle-aged individuals, pot
Externí odkaz:
https://doaj.org/article/792227af26bb4898b50fc41e24abb5db
Autor:
Christopher S. Anderson, Mark Y. Sangster, Hongmei Yang, Thomas J. Mariani, Sidhartha Chaudhury, David J. Topham
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background In 2009, a novel influenza vaccine was distributed worldwide to combat the H1N1 influenza “swine flu” pandemic. However, antibodies induced by the vaccine display differences in their specificity and cross-reactivity dependent
Externí odkaz:
https://doaj.org/article/3a22b7dfc3144b44a88af1e86ed32785
Autor:
Matthew N McCall, Chin-Yi Chu, Lu Wang, Lauren Benoodt, Juilee Thakar, Anthony Corbett, Jeanne Holden-Wiltse, Christopher Slaunwhite, Alex Grier, Steven R Gill, Ann R Falsey, David J Topham, Mary T Caserta, Edward E Walsh, Xing Qiu, Thomas J Mariani
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009617 (2021)
Respiratory syncytial virus (RSV) infection results in millions of hospitalizations and thousands of deaths each year. Variations in the adaptive and innate immune response appear to be associated with RSV severity. To investigate the host response t
Externí odkaz:
https://doaj.org/article/a52cd67a7c7c44b2b50006822ce0ee4b
Autor:
Emma C. Reilly, Mike Sportiello, Kris Lambert Emo, Andrea M. Amitrano, Rakshanda Jha, Ashwin B. R. Kumar, Nathan G. Laniewski, Hongmei Yang, Minsoo Kim, David J. Topham
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
CD8 T cell memory offers critical antiviral protection, even in the absence of neutralizing antibodies. The paradigm is that CD8 T cell memory within the lung tissue consists of a mix of circulating TEM cells and non-circulating TRM cells. However, b
Externí odkaz:
https://doaj.org/article/7b93e7b976014f638ba3b9ee4445492d