Zobrazeno 1 - 10
of 28
pro vyhledávání: '"J Thomas, Hannich"'
Autor:
Chrysanthi Kagiou, Jose A. Cisneros, Jakob Farnung, Joanna Liwocha, Fabian Offensperger, Kevin Dong, Ka Yang, Gary Tin, Christina S. Horstmann, Matthias Hinterndorfer, Joao A. Paulo, Natalie S. Scholes, Juan Sanchez Avila, Michaela Fellner, Florian Andersch, J. Thomas Hannich, Johannes Zuber, Stefan Kubicek, Steven P. Gygi, Brenda A. Schulman, Georg E. Winter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600 human E3 ligases are currently amenable to t
Externí odkaz:
https://doaj.org/article/122c230e01c4426bb2025a22bb1c70c0
Autor:
Lennart Enders, Marton Siklos, Jan Borggräfe, Stefan Gaussmann, Anna Koren, Monika Malik, Tatjana Tomek, Michael Schuster, Jiří Reiniš, Elisa Hahn, Andrea Rukavina, Andreas Reicher, Tamara Casteels, Christoph Bock, Georg E. Winter, J. Thomas Hannich, Michael Sattler, Stefan Kubicek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract SMNDC1 is a Tudor domain protein that recognizes di-methylated arginines and controls gene expression as an essential splicing factor. Here, we study the specific contributions of the SMNDC1 Tudor domain to protein-protein interactions, subc
Externí odkaz:
https://doaj.org/article/c2dd0a0771874edca633713ba3239cc7
Autor:
Carla E. Cadena del Castillo, J. Thomas Hannich, Andres Kaech, Hirohisa Chiyoda, Jonathan Brewer, Masamitsu Fukuyama, Nils J. Færgeman, Howard Riezman, Anne Spang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone recep
Externí odkaz:
https://doaj.org/article/5e7eddb79b0041a6b55bc4fe25d73484
Autor:
Christoph Driessen, Herman S. Overkleeft, Christopher D. Vulpe, Hesso Farhan, Marc Pilon, Celia R. Berkers, Bart Everts, Alex Loguinov, J. Thomas Hannich, Heinz Ludwig, Arnold Bolomsky, Julia Huber, Marcus Ståhlman, Jan Borén, Bogdan I. Florea, Marc Sathianathan, Lorina Büchler, Santosh Phuyal, Mario Ruiz, Alwin J. van der Ham, Esther A. Zaal, Amin Sobh, Sara C. Stolze, Andrej Besse, Lenka Besse
Cells pre-treated for 3h with 10 µM brefeldin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33552871e6e1733063c907c47c924f2a
https://doi.org/10.1158/0008-5472.22429021
https://doi.org/10.1158/0008-5472.22429021
Autor:
Christoph Driessen, Herman S. Overkleeft, Christopher D. Vulpe, Hesso Farhan, Marc Pilon, Celia R. Berkers, Bart Everts, Alex Loguinov, J. Thomas Hannich, Heinz Ludwig, Arnold Bolomsky, Julia Huber, Marcus Ståhlman, Jan Borén, Bogdan I. Florea, Marc Sathianathan, Lorina Büchler, Santosh Phuyal, Mario Ruiz, Alwin J. van der Ham, Esther A. Zaal, Amin Sobh, Sara C. Stolze, Andrej Besse, Lenka Besse
Supplementary Methods, figures and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182275f89436b405bcad2fd645409448
https://doi.org/10.1158/0008-5472.22429033
https://doi.org/10.1158/0008-5472.22429033
Autor:
Christoph Driessen, Herman S. Overkleeft, Christopher D. Vulpe, Hesso Farhan, Marc Pilon, Celia R. Berkers, Bart Everts, Alex Loguinov, J. Thomas Hannich, Heinz Ludwig, Arnold Bolomsky, Julia Huber, Marcus Ståhlman, Jan Borén, Bogdan I. Florea, Marc Sathianathan, Lorina Büchler, Santosh Phuyal, Mario Ruiz, Alwin J. van der Ham, Esther A. Zaal, Amin Sobh, Sara C. Stolze, Andrej Besse, Lenka Besse
The HIV-protease inhibitor nelfinavir has shown broad anticancer activity in various preclinical and clinical contexts. In patients with advanced, proteasome inhibitor (PI)–refractory multiple myeloma, nelfinavir-based therapy resulted in 65% parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e901416a1a64be63e31f0e7aa9f10287
https://doi.org/10.1158/0008-5472.c.6513214.v1
https://doi.org/10.1158/0008-5472.c.6513214.v1
Autor:
Marko Cigler, Hana Imrichova, Fabian Frommelt, Laura Depta, Andrea Rukavina, Chrysanthi Kagiou, J. Thomas Hannich, Cristina Mayor-Ruiz, Giulio Superti-Furga, Sonja Sievers, Luca Laraia, Herbert Waldmann, Georg E. Winter
Metabolic alterations in cancer precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product inspired small molecules can provide a resource of invaluable chemotypes. Here, we identify orpinolide, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80fe4d3822530f540a38153468b74d19
https://doi.org/10.1101/2023.03.15.532743
https://doi.org/10.1101/2023.03.15.532743
Autor:
Caroline A. Heckman, Arnold Bolomsky, Heinz Ludwig, Stefan Kubicek, Niklas Zojer, Jo Caers, Andrej Besse, Juho J. Miettinen, Helene Breid, Alina Malyutina, Wolfgang Hübl, Martin Schreder, Alun Owen Parsons, Lenka Besse, Jing Tang, Christoph Driessen, J. Thomas Hannich, Julia Huber, Stefanie Fellinger, Kristaps Klavins
Publikováno v:
Blood Advances. 5:4125-4139
Antiapoptotic Bcl-2 family members have recently (re)emerged as key drug targets in cancer, with a tissue- and tumor-specific activity profile of available BH3 mimetics. In multiple myeloma, MCL-1 has been described as a major gatekeeper of apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4ea478f3f22662a9e88648ef15da78
https://doi.org/10.1182/bloodadvances.2020003826
https://doi.org/10.1182/bloodadvances.2020003826
Autor:
Mary Akinyi, Nyonda, Joachim, Kloehn, Piotr, Sosnowski, Aarti, Krishnan, Gaëlle, Lentini, Bohumil, Maco, Jean-Baptiste, Marq, J Thomas, Hannich, Gerard, Hopfgartner, Dominique, Soldati-Favre
Publikováno v:
Cell reports. 40(7)
Toxoplasma gondii possesses sphingolipid synthesis capabilities and is equipped to salvage lipids from its host. The contribution of these two routes of lipid acquisition during parasite development is unclear. As part of a complete ceramide synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71fcd3809063a4d22ae51101cc43bccf
https://pubmed.ncbi.nlm.nih.gov/35977499
https://pubmed.ncbi.nlm.nih.gov/35977499
Autor:
Matthäus Metz, Marianna Beghini, Peter Wolf, Lorenz Pfleger, Martina Hackl, Magdalena Bastian, Angelika Freudenthaler, Jürgen Harreiter, Maximilian Zeyda, Sabina Baumgartner-Parzer, Rodrig Marculescu, Nara Marella, J. Thomas Hannich, Georg Györi, Gabriela Berlakovich, Michael Roden, Michael Krebs, Robert Risti, Aivar Lõokene, Michael Trauner, Alexandra Kautzky-Willer, Martin Krššák, Herbert Stangl, Clemens Fürnsinn, Thomas Scherer
Publikováno v:
Cell Metabolism. 34:1719-1731.e5
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0709f89cf875fdc273a4391a92c75fd
https://doi.org/10.1016/j.cmet.2022.09.020
https://doi.org/10.1016/j.cmet.2022.09.020