Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma

Autor: Igor Dolgalev, Hua Zhou, Nina Murrell, Hortense Le, Theodore Sakellaropoulos, Nicolas Coudray, Kelsey Zhu, Varshini Vasudevaraja, Anna Yeaton, Chandra Goparaju, Yonghua Li, Imran Sulaiman, Jun-Chieh J. Tsay, Peter Meyn, Hussein Mohamed, Iris Sydney, Tomoe Shiomi, Sitharam Ramaswami, Navneet Narula, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Wei-Yi Cheng, James Cai, Salman Punekar, Vamsidhar Velcheti, Daniel H. Sterman, J. T. Poirier, Ben Neel, Kwok-Kin Wong, Luis Chiriboga, Adriana Heguy, Thales Papagiannakopoulos, Bettina Nadorp, Matija Snuderl, Leopoldo N. Segal, Andre L. Moreira, Harvey I. Pass, Aristotelis Tsirigos

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Approximately 30% of early-stage lung adenocarcinoma patients present with disease progression after successful surgical resection. Despite efforts of mapping the genetic landscape, there has been limited success in discovering predictive bi

Externí odkaz: https://doaj.org/article/326ae301e3024de2b6652801e0ebede8

Quantitation of Murine Stroma and Selective Purification of the Human Tumor Component of Patient-Derived Xenografts for Genomic Analysis.

Autor: Valentina E Schneeberger, Viola Allaj, Eric E Gardner, J T Poirier, Charles M Rudin

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0160587 (2016)

Patient-derived xenograft (PDX) mouse models are increasingly used for preclinical therapeutic testing of human cancer. A limitation in molecular and genetic characterization of PDX tumors is the presence of integral murine stroma. This is particular

Externí odkaz: https://doaj.org/article/cbb95f589d664116b143485e3d1a102e

Spatial Transcriptome‐Wide Profiling of Small Cell Lung Cancer Reveals Intra‐Tumoral Molecular and Subtype Heterogeneity.

Autor: Zhang, Zicheng^1,2, Sun, Xujie², Liu, Yutao³ liuyutao@cicams.ac.cn, Zhang, Yibo¹, Yang, Zijian¹, Dong, Jiyan², Wang, Nan⁴, Ying, Jianming², Zhou, Meng¹ zhoumeng@wmu.edu.cn, Yang, Lin² yanglin@cicams.ac.cn

Publikováno v: Advanced Science. 8/21/2024, Vol. 11 Issue 31, p1-15. 15p.

Nanoparticles (NPs)-mediated targeted regulation of redox homeostasis for effective cancer therapy.

Autor: Zixuan Zhao^1,2,3, Yuan Cao^2,3, Rui Xu^2,3, Junyue Fang^2,3, Yuxuan Zhang^2,3, Xiaoding Xu^1,2,3, Linzhuo Huang^2,3 huanglzh8@mail2.sysu.edu.cn, Rong Li¹ 1991020015@usc.edu.cn

Publikováno v: Smart Materials in Medicine. Jun2024, Vol. 5 Issue 2, p291-320. 30p.

Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC.

Autor: Zhao, Xian^1,2 (AUTHOR) xianzhao1985@sjtu.edu.cn, Cao, Yingting¹ (AUTHOR), Lu, Runhui¹ (AUTHOR), Zhou, Zihan¹ (AUTHOR), Huang, Caihu¹ (AUTHOR), Li, Lian¹ (AUTHOR), Huang, Jiayi¹ (AUTHOR), Chen, Ran¹ (AUTHOR), Wang, Yanli¹ (AUTHOR), Huang, Jian¹ (AUTHOR), Cheng, Jinke¹ (AUTHOR), Zheng, Junke³ (AUTHOR), Fu, Yujie² (AUTHOR) fuyujie@renji.com, Yu, Jianxiu^1,2 (AUTHOR) jianxiu.yu@shsmu.edu.cn

Publikováno v: Advanced Science. 4/17/2024, Vol. 11 Issue 15, p1-20. 20p.