Výsledky vyhledávání - "J T, VanderLugt"

Clinical proof-of-concept study with MSDC-0160, a prototype mTOT-modulating insulin sensitizer

Autor: Wade J. Adams, R Zhou, D G Orloff, A Shashlo, Jerry R. Colca, J T VanderLugt, William G. McDonald, J Liang

Publikováno v: Clinical Pharmacology and Therapeutics

It may be possible to achieve insulin sensitivity through the recently identified mitochondrial target of thiazolidinediones (mTOT), thereby avoiding peroxisome proliferator–activated receptor-γ (PPAR-γ)-dependent side effects. In this phase IIb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468b0eb13615ad33ecd096273333eac9
https://pubmed.ncbi.nlm.nih.gov/23462886

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Suppression of inducible ventricular tachycardia by ibutilide in patients with coronary artery disease. Ibutilide Investigators

Autor: M A, Wood, B S, Stambler, K A, Ellenbogen, D M, Gilligan, K T, Perry, L K, Wakefield, J T, VanderLugt

Publikováno v: American heart journal. 135(6 Pt 1)

Recent studies suggest that class III antiarrhythmic agents may have enhanced efficacy in the treatment of ventricular tachycardia. This study describes the first clinical assessment of the new class III agent ibutilide to suppress inducible monomorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dadc05df997e5f8a586e159d477a2e19
https://pubmed.ncbi.nlm.nih.gov/9630110

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Conversion efficacy and safety of intravenous ibutilide compared with intravenous procainamide in patients with atrial flutter or fibrillation

Autor: A S, Volgman, P A, Carberry, B, Stambler, W R, Lewis, G H, Dunn, K T, Perry, J T, Vanderlugt, P R, Kowey

Publikováno v: Journal of the American College of Cardiology. 31(6)

This multicenter study compared the efficacy and safety of ibutilide versus procainamide for conversion of recent-onset atrial flutter or fibrillation.Ibutilide fumarate is an intravenous (IV) class III antiarrhythmic agent that has been shown to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cc3de16edbba8770d037132bd40af64
https://pubmed.ncbi.nlm.nih.gov/9581743

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The cost-effectiveness of ibutilide versus electrical cardioversion in the conversion of atrial fibrillation and flutter to normal rhythm

Autor: G A, Zarkin, M V, Bala, B, Calingaert, J T, VanderLugt

Publikováno v: The American journal of managed care. 3(9)

Atrial fibrillation and atrial flutter are cardiac rhythm disorders that are often symptomatic and may interfere with the heart's function, limiting its effectiveness. These arrhythmias are responsible for a large number of hospitalizations at a sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f49deb8e6d5acd149d67491903918b22
https://pubmed.ncbi.nlm.nih.gov/10178487

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Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. Ibutilide Repeat Dose Study Investigators

Autor: B S, Stambler, M A, Wood, K A, Ellenbogen, K T, Perry, L K, Wakefield, J T, VanderLugt

Publikováno v: Circulation. 94(7)

Currently available antiarrhythmic drugs have limited efficacy for acute termination of atrial fibrillation and flutter, especially if the arrhythmia is not of recent onset. The purpose of this multicenter study was to determine the efficacy and safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49c4a1bd35ad5f687e7cfa2c82002d34
https://pubmed.ncbi.nlm.nih.gov/8840835

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New methods to detect the effect of alteration in gastric pH and intestinal transit by metoclopramide and propantheline using a continuous gastric pH probe and hydrogen breath analysis

Autor: G S, Hughes, J T, VanderLugt, M, Bays, D F, Bohan, S F, Francom

Publikováno v: Methods and findings in experimental and clinical pharmacology. 12(2)

The effects of oral doses of metoclopramide (M, 10 mg) and propantheline (P, 30 mg) on alteration in gastric pH and emptying were determined using a continuous pH probe (Digitrapper, Synectics) and hydrogen breath analysis (HBA, QuinTron) in eight ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::82b2ed6bf40451a5e47877a14be7e091
https://pubmed.ncbi.nlm.nih.gov/2319840

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Pharmacokinetics of furegrelate after oral administration to normal humans

Autor: D B, Lakings, J M, Friis, C M, Lunan, J T, VanderLugt, J S, Mohrland

Publikováno v: Pharmaceutical research. 6(1)

Furegrelate sodium is a thromboxane synthetase inhibitor with potential for the treatment of various diseases including hypertension, thrombosis, and renal disorders. The absorption and disposition of the parent drug in normal male volunteers have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ffeeb23bcff2748edc307a5e92514cfc
https://pubmed.ncbi.nlm.nih.gov/2717519

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Pharmacokinetics and pharmacodynamics of alprazolam after oral and IV administration

Autor: J. P. Phillips, Randall B. Smith, J. T. Vanderlugt, Patricia D. Kroboth, Randy P. Juhl

Publikováno v: Psychopharmacology. 84(4)

Six fasting male subjects (20-32 years of age) received an oral tablet and an IV 1.0-mg dose of alprazolam in a crossover-design study. Alprazolam plasma concentration in multiple samples during 36 h after dosing was determined by electron-capture ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9622b82731584c4e03b7b9f43d68572f
https://pubmed.ncbi.nlm.nih.gov/6152055

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