Zobrazeno 1 - 10
of 56
pro vyhledávání: '"J T, Tildon"'
Publikováno v:
Neurochemical Research. 22:1159-1164
Leucine and α-ketoisocaproate (α-KIC) were perfused at increasing concentrations into rat brain hippocampus by microdialysis to mimic the conditions of maple syrup urine disease. The effects of elevated leucine or α-KIC on the oxidation of L-[U-14
Publikováno v:
Pediatric Research. 40:135-141
Glucose has been thought to be the primary substrate for energy metabolism in the developing lung; however, alternate substrates are used for energy metabolism in other organs. To examine the role of alternate substrates in the lung, we measured rate
Publikováno v:
Developmental Neuroscience. 18:420-425
alpha-Ketoisocaproate was infused into the brain of free-moving, awake rats by microdialysis to create a microenvironment similar to that found in maple syrup urine disease. The eluate of the probe was analyzed for amino acids to determine if alpha-k
Publikováno v:
Neurochemical Research. 20:1491-1501
Malate has a number of key roles in the brain, including its function as a tricarboxylic acid (TCA) cycle intermediate, and as a participant in the malate-aspartate shuttle. In addition, malate is converted to pyruvate and CO2 via malic enzyme and ma
Publikováno v:
Molecular and Chemical Neuropathology. 19:219-233
The effect of aluminum on the metabolism of glutamate and glutamine in astrocytes was studied to provide information about a possible biochemical mechanism for aluminum neurotoxicity and its potential contribution to neurodegenerative disease. Exposu
Publikováno v:
Developmental Neuroscience. 15:226-332
This report extends the finding that serum protein(s) (0.5 mg/ml) caused a 50% decrease in the rate of glucose oxidation by dissociated brain cells with only marginal effects on the oxidation of other substrates. Since dissociated cells represent a h
Publikováno v:
Neurochemical Research. 15:1115-1122
Glutamine synthetase (GS) activity in cultured rat astrocytes was measured in extracts and compared to the intracellular rate of glutamine synthesis by intact control astrocytes or astrocytes exposed to 1 mM 8-bromo-cAMP (8Br-cAMP) + 1 microM dexamet
Publikováno v:
Developmental neuroscience. 20(4-5)
Since lactate released by glial cells may be a key substrate for energy in neurons, the kinetics for the uptake of L-[U-14C]lactate by cortical synaptic terminals from 7- to 8-week-old rat brain were determined. Lactate uptake was temperature-depende
Publikováno v:
Neurochemical research. 22(9)
Leucine and alpha-ketoisocaproate (alpha-KIC) were perfused at increasing concentrations into rat brain hippocampus by microdialysis to mimic the conditions of maple syrup urine disease. The effects of elevated leucine or alpha-KIC on the oxidation o
Publikováno v:
Pediatric research. 40(1)
Glucose has been thought to be the primary substrate for energy metabolism in the developing lung; however, alternate substrates are used for energy metabolism in other organs. To examine the role of alternate substrates in the lung, we measured rate