Zobrazeno 1 - 10 of 10 pro vyhledávání: '"J T, Safrit"'
2
Induction of Humoral Immune Responses following Vaccination with Envelope-Containing, Formaldehyde-Treated, Thermally Inactivated Human Immunodeficiency Virus Type 1
Autor: J. T. Safrit, Harold M. McClure, J. F. Hsu, Ian Y. Chen, V. Gudeman, Betty Poon, Kathie Grovit-Ferbas, Terri Wrin, Christina M. R. Kitchen, C. Petropoulos
Publikováno v: Journal of Virology. 79:4927-4935
The lack of success of subunit human immunodeficiency virus type 1 (HIV-1) vaccines to date suggests that multiple components or a complex virion structure may be required. We previously demonstrated retention of the major conformational epitopes of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e45a291bc476844c2ef688fe880f4fe
https://doi.org/10.1128/jvi.79.8.4927-4935.2005
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4
A region of the third variable loop of HIV-1 gp120 is recognized by HLA-B7-restricted CTLs from two acute seroconversion patients
Autor: J T Safrit, A Y Lee, C A Andrews, R A Koup
Publikováno v: The Journal of Immunology. 153:3822-3830
HIV-1 envelope-specific CTL clones were isolated from the peripheral blood of two patients from within weeks of seroconversion. These clones were CD8+ and restricted by the HLA-B7 molecule. The minimum epitope recognized by the clones was determined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d5d6cc81477654ec85793399d854fe3
https://doi.org/10.4049/jimmunol.153.8.3822
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5
Synergistic effect of tumor necrosis factor-alpha- and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines
Autor: H Morimoto, J T Safrit, B Bonavida
Publikováno v: The Journal of Immunology. 147:2609-2616
Recent studies have demonstrated that diphtheria toxin (DTX) also mediates target cell lysis, and the mechanism of cytotoxicity has many features similar to those of cytotoxicity mediated by TNF-alpha. Thus, we hypothesized that DTX and TNF-alpha, us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1416046f5d4b21c2b68a36120d4dc37
https://doi.org/10.4049/jimmunol.147.8.2609
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6
Processing of HIV-1 envelope glycoprotein for class I-restricted recognition: dependence on TAP1/2 and mechanisms for cytosolic localization
Autor: R L, Ferris, C, Hall, N V, Sipsas, J T, Safrit, A, Trocha, R A, Koup, R P, Johnson, R F, Siliciano
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(3)
Processing of viral proteins for recognition by CTL involves degradation of the proteins in the cytosol of an infected cell followed by transport of the resulting peptides into the endoplasmic reticulum (ER) by the TAP1/2 complex. Uncertainty exists
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bd0e849e0759d8a6a8a5816419fce2f
https://pubmed.ncbi.nlm.nih.gov/9973386
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7
An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL
Autor: S A, Hammond, R P, Johnson, S A, Kalams, B D, Walker, M, Takiguchi, J T, Safrit, R A, Koup, R F, Siliciano
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 154(11)
The lysis of virally infected cells by CTLs requires the recognition of processed fragments of viral proteins presented in association with class I MHC molecules on the surfaces of infected cells. Processing begins in the cytosol with the degradation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc9356a61f5e8c9c0946c6e79451eaa3
https://pubmed.ncbi.nlm.nih.gov/7538543
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8
A region of the third variable loop of HIV-1 gp120 is recognized by HLA-B7-restricted CTLs from two acute seroconversion patients
Autor: J T, Safrit, A Y, Lee, C A, Andrews, R A, Koup
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 153(8)
HIV-1 envelope-specific CTL clones were isolated from the peripheral blood of two patients from within weeks of seroconversion. These clones were CD8+ and restricted by the HLA-B7 molecule. The minimum epitope recognized by the clones was determined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::953f716cd8f6389e0567943c397af6e4
https://pubmed.ncbi.nlm.nih.gov/7523505
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9
Sensitivity of resistant human tumor cell lines to tumor necrosis factor and adriamycin used in combination: correlation between down-regulation of tumor necrosis factor-messenger RNA induction and overcoming resistance
Autor: J T, Safrit, B, Bonavida
Publikováno v: Cancer research. 52(23)
A number of human tumor cell lines of various histological origin were examined for their sensitivity and resistance to tumor necrosis factor-alpha (TNF) and Adriamycin (ADR). Six ovarian lines, and one each of a renal, lung, and B-cell line, were te
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54a189b4e5ac3823a3a32eda293b77eb
https://pubmed.ncbi.nlm.nih.gov/1330298
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10
Synergistic effect of tumor necrosis factor-alpha- and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines
Autor: H, Morimoto, J T, Safrit, B, Bonavida
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 147(8)
Recent studies have demonstrated that diphtheria toxin (DTX) also mediates target cell lysis, and the mechanism of cytotoxicity has many features similar to those of cytotoxicity mediated by TNF-alpha. Thus, we hypothesized that DTX and TNF-alpha, us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2fc9a378d761a0a0bc223800f359f8f
https://pubmed.ncbi.nlm.nih.gov/1918981
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