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The occurence of rare Ciboria aestivalis in Europe

Autor: R. Galan, J. T. Palmer

Publikováno v: Czech Mycology. 52:277-287

sp.) in the United States, the species has alsobeen reported on other pomaceous and stone fruits in Australia. A recent report from France isbased on a misidentification, whilst a British reference to "imported fruit" refers to mummifiedquinces broug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5db60f03b0a8e58cdae087d8ef0be062
https://doi.org/10.33585/cmy.52404

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Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors

Autor: Jed E Olson, J T Palmer, Philip J. Rosenthal, J L Klaus, D Rasnick, G K Lee

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:1600-1603

We evaluated the antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. A number of vinyl sulfones strongly inhibited falcipain, a Plasmodium falciparum cysteine proteinase that is a critical hemoglobinase. In studies of cultured paras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c573fc98397c36c34c2a34ab5651908
https://doi.org/10.1128/aac.40.7.1600

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Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor

Autor: S L, Biroc, S, Gay, K, Hummel, C, Magill, J T, Palmer, D R, Spencer, S, Sa, J L, Klaus, B A, Michel, D, Rasnick, R E, Gay

Publikováno v: Arthritis and rheumatism. 44(3)

Cysteine proteases are postulated to play a role in tissue destruction in the joints of animals with arthritis. The purpose of the present study was to confirm the concept that cysteine proteases are enzymes involved in the pathology of rheumatoid ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd5a4e15044ec4a0becfc7c20ce23dec
https://pubmed.ncbi.nlm.nih.gov/11263786

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Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones

Autor: Lihong Xia, J. T. Palmer, A. Lipyansky, J. Kilb, Heike Wex, Dieter Brömme, Zhenqiang Li, V. Breuil, David W. Dempster, L. Stein

Publikováno v: Biological chemistry. 380(6)

We have localized cathepsin K in rat osteoclasts and within exposed resorption pits by immuno-fluorescence microscopy. Intracellular staining using an antibody raised against recombinant mouse cathepsin K was vesicular and uniformly distributed throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062bff9988e8de35e366ba90e90221d9
https://pubmed.ncbi.nlm.nih.gov/10430032

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Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex

Autor: C J, Linnevers, M E, McGrath, R, Armstrong, F R, Mistry, M G, Barnes, J L, Klaus, J T, Palmer, B A, Katz, D, Brömme

Publikováno v: Protein science : a publication of the Protein Society. 6(4)

Cathepsin K is a cysteine protease of the papain family, which is predominantly expressed in osteoclasts, and is regarded as a key protease in bone remodeling. To facilitate structural studies of the protein, the wild-type sequence of the protease ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2792cda47576049504b42f02db834f5f
https://pubmed.ncbi.nlm.nih.gov/9098904

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Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L

Autor: J L Klaus, David Rasnick, Dieter Brömme, K Okamoto, J T Palmer

Peptidyl vinyl sulphones are a novel class of extremely potent and specific cysteine protease inhibitors. They are highly active against the therapeutically important cathepsins O2, S and L. The highest kinact/Ki values exceed 107 M-1·s-1 for cathep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8320fa9acb1ce914d34fa5e791ae114b
https://europepmc.org/articles/PMC1217200/

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The effects of fluoromethyl ketone inhibitors of cathepsin B on adjuvant induced arthritis

Autor: R E, Esser, L M, Watts, R A, Angelo, L P, Thornburg, J J, Prior, J T, Palmer

Publikováno v: The Journal of rheumatology. 20(7)

Peptidyl fluoromethyl ketones with the structure carbobenzoxy (Z)-L-phenylalanine-L-alanine-CH2F (MDL 201,053), and its diastereomer Z-L-phenylalanine-D-alanine-CH2F (MDL 201,117), were synthesized and evaluated in vitro for inhibition of purified hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eca1f79cc5e4d2b33fcfc5ec099ae618
https://pubmed.ncbi.nlm.nih.gov/8371213

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Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase

Autor: Philip J. Rosenthal, J T Palmer, W S Wollish, D Rasnick

Publikováno v: The Journal of clinical investigation. 88(5)

We previously identified a Plasmodium falciparum trophozoite cysteine proteinase (TCP) and hypothesized that it is required for the degradation of host hemoglobin by intraerythrocytic malaria parasites. To test this hypothesis and to evaluate TCP as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0718feb3700a50c8cf61d63b3b2a0a
https://pubmed.ncbi.nlm.nih.gov/1939639

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