Zobrazeno 1 - 10 of 39 pro vyhledávání: '"J T, MacGregor"'
1
Expulsion of demecolcine-induced micronuclei from mouse bone marrow polychromatic erythrocytes
Autor: Joseph W. Parton, Michael L. Garriott, Joe E. Beyers, J. T. MacGregor
Publikováno v: Environmental and Molecular Mutagenesis. 17:79-83
The mouse micronucleus test is a valuable tool for evaluating in vivo chromosome damage produced by test articles in polychromatic erythrocytes of bone marrow. Compounds that are clastogens, such as cyclophosphamide, induce micronuclei that are small
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a95de9d3f97a4448ae0e0ecf0363c9
https://doi.org/10.1002/em.2850170203
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2
Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat
Autor: J. T. MacGregor, M. E. Bishop, J. P. McNamee, M. Hayashi, N. Asano, A. Wakata, M. Nakajima, J. Saito, A. Aidoo, M. M. Moore, S. D. Dertinger
Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 94(1)
We have evaluated a flow cytometric method that allows assessment of micronucleated reticulocytes (MN-RETs) in microliter quantities of peripheral blood and compared results using this assay with those of established microscopic methods of scoring bo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a0be04b11233118b5d16eaaba7c79c
https://pubmed.ncbi.nlm.nih.gov/16888079
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4
Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program
Autor: K L, Witt, A, Knapton, C M, Wehr, G J, Hook, J, Mirsalis, M D, Shelby, J T, MacGregor
Publikováno v: Environmental and molecular mutagenesis. 36(3)
The mouse peripheral blood micronucleus (MN) test was performed on samples collected from 20 short-term, 67 subchronic, and 5 chronic toxicity and carcinogenicity studies conducted by the National Toxicology Program (NTP). Data are presented for stud
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56994e0a707010593209f63284d9a380
https://pubmed.ncbi.nlm.nih.gov/11044899
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5
In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring
Autor: M, Hayashi, J T, MacGregor, D G, Gatehouse, I D, Adler, D H, Blakey, S D, Dertinger, G, Krishna, T, Morita, A, Russo, S, Sutou
Publikováno v: Environmental and molecular mutagenesis. 35(3)
An expert working group on the in vivo micronucleus assay, formed as part of the International Workshop on Genotoxicity Test Procedures (IWGTP), discussed protocols for the conduct of established and proposed micronucleus assays at a meeting held Mar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b99f8b6e483adbc18a9830063603484
https://pubmed.ncbi.nlm.nih.gov/10737958
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7
Determination of tissue distribution of an intramuscular plasmid vaccine using PCR and in situ DNA hybridization
Autor: Richard A. Winegar, Kathleen O’Loughlin, Joseph Albert Monforte, J. T. MacGregor, C. J. Rudd, K. D. Suing
Publikováno v: Human gene therapy. 7(17)
The increasing use of nucleic acid-based therapeutics has created a need for new methods of determining tissue distribution and levels. Radiolabel methods may not always be appropriate because nucleic acids are easily degraded. Quantitation using the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa82866e3659db70ba14304fa9008bc
https://pubmed.ncbi.nlm.nih.gov/8934232
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8
Micronuclei in mouse skin cells following in vivo exposure to benzo[a]pyrene, 7,12-dimethylbenz[a]anthracene, chrysene, pyrene and urethane
Autor: Robert S.U. Baker, J. T. MacGregor, Shuilin He
Publikováno v: Environmental and molecular mutagenesis. 17(3)
Detection of micronuclei (MN) in skin cells from HRA/Skh hairless mice treated with chemical or physical agents may prove informative in qualitative and quantitative studies of skin carcinogenesis. MN induction and cell survival were estimated in cyt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceff500d0c155622ddbcdc039cdb32ab
https://pubmed.ncbi.nlm.nih.gov/1902414
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9
Evaluation of the mutagenicity of the anti-inflammatory drug salicylazosulfapyridine (SASP)
Autor: J. T. MacGregor, J. B. Bishop, D. K. Gulati, Kristine L. Witt
Publikováno v: Mutagenesis. 5(6)
Salicylazosulfapyridine, commonly known as sulfasalazine or SASP, is an anti-inflammatory drug that is widely used in the treatment of diseases such as ulcerative colitis and Crohn's disease. Increases in sister chromatid exchanges (SCE) and micronuc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fce54fb0854e2c1a542240d331ed34d
https://pubmed.ncbi.nlm.nih.gov/1979833
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10
Micronucleated erythrocytes as an index of cytogenetic damage in humans: demographic and dietary factors associated with micronucleated erythrocytes in splenectomized subjects
Autor: D F, Smith, J T, MacGregor, R A, Hiatt, N K, Hooper, C M, Wehr, B, Peters, L R, Goldman, L A, Yuan, P A, Smith, C E, Becker
Publikováno v: Cancer research. 50(16)
Erythrocytes containing micronuclei serve as an indicator of genotoxic exposure in splenectomized individuals. Micronucleated erythrocytes, derived from cytogenetically damaged RBC precursors, are not selectively removed from peripheral blood in indi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::275c6683624bd7f7d1f2c0336de6f2d2
https://pubmed.ncbi.nlm.nih.gov/2379170
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