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Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault

Autor: J T Arnold, J T Isaacs

Publikováno v: Endocrine-related cancer. 9(1)

The acquisition of an androgen-independent phenotype by prostate cancer cells is presently a death sentence for patients. In order to have a realistic chance of changing this outcome, an understanding of what drives the progression to androgen indepe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3ed3619f82e02af32f2d87284c4e91
https://pubmed.ncbi.nlm.nih.gov/11914183

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Therapeutic implications of enhanced G(0)/G(1) checkpoint control induced by coculture of prostate cancer cells with osteoblasts

Autor: J, Pinski, A, Parikh, G S, Bova, J T, Isaacs

Publikováno v: Cancer research. 61(17)

Osteoblastic metastases are common in lethal prostate cancer. Effective therapy for bone metastases is lacking. Thus, developing an appropriate in vitro screening system is critical to prioritize which of the newly developed agents should undergo add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0399f458428ec33b07041f4aba8f673
https://pubmed.ncbi.nlm.nih.gov/11522628

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Pan-trk inhibition decreases metastasis and enhances host survival in experimental models as a result of its selective induction of apoptosis of prostate cancer cells

Autor: A T, Weeraratna, S L, Dalrymple, J C, Lamb, S R, Denmeade, S, Miknyoczki, C A, Dionne, J T, Isaacs

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8)

During the progression of prostate cancer, molecular changes occur resulting in the autocrine production of a series of neurotrophins by the malignant cells. This is coupled with expression of high-affinity cognate receptors for these ligands, termed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d122f6109a8262ce968d5c631b3ffc1b
https://pubmed.ncbi.nlm.nih.gov/11489797

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Activation of latent protease function of pro-hK2, but not pro-PSA, involves autoprocessing

Autor: S R, Denmeade, J, Lövgren, S R, Khan, H, Lilja, J T, Isaacs

Publikováno v: The Prostate. 48(2)

Human glandular kallikrein 2 (hK2) and prostate-specific antigen (PSA) are members of an extensive kallikrein family of proteases. Both proteases are secreted as zymogens or proenzymes containing a seven amino acid propeptide that must be proteolytic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbd1671648a8a3613c08e693c75167de
https://pubmed.ncbi.nlm.nih.gov/11433422

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Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells

Autor: J, Gao, J T, Arnold, J T, Isaacs

Publikováno v: Cancer research. 61(13)

Normal adult prostate epithelium of both human and rat origin was transplanted with Matrigel into intact or androgen-ablated (i.e., castrated) nude mice. Within these transplants, an influx of mouse mesenchymal cells was one of the earliest events to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eca83b0a39ed591572cfad419d9781e3
https://pubmed.ncbi.nlm.nih.gov/11431338

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Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer

Autor: T, Ichikawa, S, Hosoki, H, Suzuki, K, Akakura, T, Igarashi, Y, Furuya, M, Oshimura, C W, Rinker-Schaeffer, N, Nihei, J C, Barrett, J T, Isaacs, H, Ito

Publikováno v: Asian journal of andrology. 2(3)

To identify the metastasis suppressor genes for prostate cancer.A copy of human chromosomes was introduced into the highly metastatic Dunning R-3327 rat prostate cancer cells by the use of microcell-mediated chromosome transfer. Relationships between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::413f979659c0148d27617aaa187d8098
https://pubmed.ncbi.nlm.nih.gov/11225974

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Prostate-specific membrane antigen (PSMA) enzyme activity is elevated in prostate cancer cells

Autor: R G, Lapidus, C W, Tiffany, J T, Isaacs, B S, Slusher

Publikováno v: The Prostate. 45(4)

Prostate-specific membrane antigen (PSMA) is a glutamate carboxypeptidase that cleaves terminal carboxy glutamates from both the neuronal dipeptide N-acetylaspartylglutamate (NAAG) and gamma-linked folate polyglutamate. The prostate enzyme has activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6be1c090a8a5ac1d412501dd84315476
https://pubmed.ncbi.nlm.nih.gov/11102961

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Rational basis for Trk inhibition therapy for prostate cancer

Autor: A T, Weeraratna, J T, Arnold, D J, George, A, DeMarzo, J T, Isaacs

Publikováno v: The Prostate. 45(2)

Prostatic cancer cells are lethal because they acquire the ability to activate survival pathways that do not require androgenic stimulation. As a rational approach to developing effective therapy for these devastating cells, specific signal transduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b263930f8a49fb64a2bda5f77210884
https://pubmed.ncbi.nlm.nih.gov/11027413

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Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene

Autor: A C, Gao, W, Lou, J T, Isaacs

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(2)

Previous studies demonstrated that the GBX2 homeobox gene is consistently overexpressed in cultured human prostate cancer cell lines. In this study, the human GBX2 cDNA was cloned and a quantitative reverse transcription-PCR method used to demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d42feddc4d3f9b560cbf332f61df894
https://pubmed.ncbi.nlm.nih.gov/10690529

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