Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J T, Handa"'
Autor:
Adiel Barak, J. Earle, D. Hauser, Z. Goldberg, J. T. Handa, B. Leigh, Lawrence S Morse, D. Kubo, P. Yipp
Publikováno v:
The British journal of radiology. 78(933)
Effective treatment for neovascular age-related macular degeneration (AMD) is currently limited. Radiation therapy, a therapeutic approach with known antiangiogenic properties, has been investigated as a modality to prevent severe visual loss in AMD.
Autor:
H, Rasmussen, K W, Chu, P, Campochiaro, P L, Gehlbach, J A, Haller, J T, Handa, Q D, Nguyen, J U, Sung
Publikováno v:
Human gene therapy. 12(16)
Age-Related Macular Degeneration (AMD) is, together with Diabetic Retinopathy, the most common cause of vision loss among adults in the U.S. and other developed countries. In the U.S., at least 1.7 million people have impaired vision due to AMD. Ever
Publikováno v:
Investigative ophthalmologyvisual science. 42(11)
To investigate how the differentiation of ARPE-19 cells affects the relative expression of the FGFR genes in response to oxidative stress.After differentiation in vitro, APRE-19 cells were treated with t-butyl hydroperoxide (tBH) or hydrogen peroxide
Publikováno v:
Investigative ophthalmologyvisual science. 42(10)
To determine an extensive mRNA phenotype of the established RPE cell line ARPE-19 when grown on a matrix modified by advanced glycation end products (AGEs).Growth Factor Reduced Matrigel (Collaborative Biomedical Products, Bedford, MA) was nonenzymat
Publikováno v:
Investigative ophthalmologyvisual science. 42(7)
Previous studies have shown that insulin-like growth factor-binding protein (IGFBP)-2 is markedly upregulated in senescent RPE cells in vitro, and might therefore be a marker of senescent cells in vivo. This study was conducted to determine whether I
Publikováno v:
Molecular vision. 7
To establish a model of mild and chronic oxidative stress using hyperoxia for retinal pigment epithelial (RPE) cells in vitro.RPE340 cells and WI38 lung fibroblasts were grown in normal oxygen (20% O2) and hyperoxia (40% O2 or 60% O2). After cell via
Publikováno v:
Molecular vision. 5
To explore the changes in expression of a set of genes in a single retinal pigment epithelial (RPE) cell line and two fibroblast cell lines as controls under culture conditions previously used for the analysis of senescent gene expression.A single hu
Publikováno v:
Investigative ophthalmologyvisual science. 40(7)
To develop a senescence-associated beta-galactosidase histochemistry and bleaching protocol for the primate posterior pole.Rhesus monkey eyes of different ages were enucleated after death, fixed in 4% paraformaldehyde for up to 16 hours, and cryoprot
Autor:
J T, Handa, N, Verzijl, H, Matsunaga, A, Aotaki-Keen, G A, Lutty, J M, te Koppele, T, Miyata, L M, Hjelmeland
Publikováno v:
Investigative ophthalmologyvisual science. 40(3)
To determine whether there is an age-related increase of pentosidine in human Bruch's membranes and to localize pentosidine and carboxymethyllysine (CML), two well-characterized, advanced glycation end products (AGEs) in aged human Bruch's membranes
Publikováno v:
Investigative ophthalmologyvisual science. 40(1)
To investigate the relation of senescence-related beta-galactosidase activity and telomere shortening to replicative senescence in cultured human retinal pigment epithelial (RPE) cells.A human RPE cell line was serially passaged until 80% of cells we