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pro vyhledávání: '"J T, Coyle"'
Autor:
J T, Coyle
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 76
This chapter recounts the author's life from childhood until he opened his research laboratory as an Assistant Professor in the Department of Pharmacology and Experimental Therapeutics at Johns Hopkins School of Medicine in 1976. It emphasizes the im
Publikováno v:
Neurology. 55:602-604
Publikováno v:
Adolescent medicine (Philadelphia, Pa.). 9(2)
Recent scientific advances in understanding the function and plasticity of the central nervous system have opened fundamental insights into the pathophysiology of various mental disorders. This chapter reviews the basic physiology of the central nerv
Autor:
T V, Nguyen, A L, Brownell, Y C, Iris Chen, E, Livni, J T, Coyle, B R, Rosen, F, Cavagna, B G, Jenkins
Publikováno v:
Synapse (New York, N.Y.). 36(1)
Receptor supersensitivity is an important concept for understanding neurotransmitter and receptor dynamics. Traditionally, detection of receptor supersensitivity has been performed using autoradiography or positron emission tomography (PET). We show
Publikováno v:
The Journal of comparative neurology. 415(1)
The enzyme glutamate carboxypeptidase II (GCP II) has been cloned from rat brain and human prostate. This enzyme, which catabolizes the neuropeptide N-acetylaspartylglutamate, has also been known as N-acetylated alpha-linked acidic dipeptidase (NAALA
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(2)
N-Acetylated alpha-linked acidic dipeptidase (NAALADase) is a neuropeptidase that may modulate glutamatergic neurotransmission. Independent of its characterization in the nervous system, one form of NAALADase was shown to be expressed at high levels
Publikováno v:
The Journal of biological chemistry. 273(32)
Jejunal folylpoly-gamma-glutamate carboxypeptidase hydrolyzes dietary folates prior to their intestinal absorption. The complete folylpoly-gamma-glutamate carboxypeptidase cDNA was isolated from a pig jejunal cDNA library using an amplified homologou
Autor:
P J, Schwartz, J T, Coyle
Publikováno v:
Synapse (New York, N.Y.). 29(3)
The cytoplasmic copper-zinc superoxide dismutase (Cu, Zn SOD; SOD-1) is an abundant and well-conserved intracellular antioxidant enzyme which has been implicated in a number of oxidative stress mediated phenomena, especially Down Syndrome, in which S
Publikováno v:
The American journal of psychiatry. 155(6)
Neurophysiological and pathological effects of ethanol may be mediated, to an important extent, via the glutamatergic system. Animal studies indicate the acute effects of ethanol disrupt glutamatergic neurotransmission by inhibiting the response of t