Zobrazeno 1 - 10
of 125
pro vyhledávání: '"J Szlachcic"'
Autor:
Jolanta Chmielowiec, Wojciech J. Szlachcic, Diane Yang, Marissa A. Scavuzzo, Katrina Wamble, Alejandro Sarrion-Perdigones, Omaima M. Sabek, Koen J. T. Venken, Malgorzata Borowiak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
In vitro differentiation of pancreatic beta cells offers a potential therapeutic approach for diabetes. Here they show human pluripotent stem cell derived pancreatic progenitors differentiate into insulin-secreting cells by crosstalk of WNT5A and BMP
Externí odkaz:
https://doaj.org/article/dd0c8e3f4f1342ab8cd8b18f288302b8
Autor:
Wojciech J. Szlachcic, Agnieszka Dabrowska, Aleksandra Milewska, Natalia Ziojla, Katarzyna Blaszczyk, Emilia Barreto-Duran, Marek Sanak, Marcin Surmiak, Katarzyna Owczarek, Dariusz Grzanka, Julia Durzynska, Krzysztof Pyrc, Malgorzata Borowiak
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104594- (2022)
Summary: Recent studies showed that SARS-CoV-2 can infect adult human pancreas and trigger pancreatic damage. Here, using human fetal pancreas samples and 3D differentiation of human pluripotent cells into pancreatic endocrine cells, we determined th
Externí odkaz:
https://doaj.org/article/db8d8f57c22c4ea6a803818eebe2efa8
Autor:
Wojciech J. Szlachcic, Natalia Ziojla, Dorota K. Kizewska, Marcelina Kempa, Malgorzata Borowiak
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
A chronic inability to maintain blood glucose homeostasis leads to diabetes, which can damage multiple organs. The pancreatic islets regulate blood glucose levels through the coordinated action of islet cell-secreted hormones, with the insulin releas
Externí odkaz:
https://doaj.org/article/a5dead1cf0cb4db288dda0c492320c7d
Autor:
Diane Yang, Sanjeet Patel, Wojciech J. Szlachcic, Jolanta Chmielowiec, Diane Scaduto, Nagireddy Putluri, Arun Sreekumar, James Suliburk, Michael Metzker, Ashok Balasubramanyam, Malgorzata Borowiak
Publikováno v:
Diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e259ebcdc12efc7c2ae35d7c87a6d96c
https://europepmc.org/articles/PMC10202761/
https://europepmc.org/articles/PMC10202761/
Publikováno v:
BioEssays. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bc602747c58a5365c670ea413972870
https://doi.org/10.1002/bies.202200186
https://doi.org/10.1002/bies.202200186
Autor:
Karolina Świtońska, Wojciech J. Szlachcic, Luiza Handschuh, Paweł Wojciechowski, Łukasz Marczak, Michał Stelmaszczuk, Marek Figlerowicz, Maciej Figiel
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2019)
In Huntington disease (HD) subtle symptoms in patients may occur years or even decades prior to diagnosis. HD changes at a molecular level may begin as early as in cells that are non-lineage committed such as stem cells or HD patients induced pluripo
Externí odkaz:
https://doaj.org/article/fa468bac5f494f09b8830f70f5317d9a
Autor:
Wojciech J. Szlachcic, Pawel M. Switonski, Wlodzimierz J. Krzyzosiak, Marek Figlerowicz, Maciej Figiel
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 9, Pp 1047-1057 (2015)
Huntington disease (HD) is a brain disorder characterized by the late onset of motor and cognitive symptoms, even though the neurons in the brain begin to suffer dysfunction and degeneration long before symptoms appear. There is currently no cure. Se
Externí odkaz:
https://doaj.org/article/6254da27dcf34e8eb99e6c210124e6c0
Autor:
Nagireddy Putluri, Sanjeet Patel, James W. Suliburk, Jolanta Chmielowiec, Diane Yang, Arun Sreekumar, Malgorzata Borowiak, Wojciech J. Szlachcic, Michael L. Metzker, Diane I. Scaduto, Ashok Balasubramanyam
Publikováno v:
Diabetes
Genetic analysis of an adult patient with an unusual course of Ketosis-Prone Diabetes (KPD) and lacking islet autoantibodies demonstrated a nucleotide variant in the 5’-UTR of PDX1, a beta-cell development gene. When differentiated to the pancreati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524a243b490a4f59f169cb619acba9c4
https://doi.org/10.2337/figshare.15070170.v2
https://doi.org/10.2337/figshare.15070170.v2
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 174-188 (2015)
Spinocerebellar ataxia type 3 (SCA3/MJD) is a neurodegenerative disease triggered by the expansion of CAG repeats in the ATXN3 gene. Here, we report the generation of the first humanized ataxin-3 knock-in mouse model (Ki91), which provides insights i
Externí odkaz:
https://doaj.org/article/9c38135ea38e4168b2ea9c4975b2b656
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Externí odkaz:
https://doaj.org/article/9e991096fea04a359cf20ab161a7880d