Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J Smith Leser"'
Autor:
Alison M Hixon, Guixia Yu, J Smith Leser, Shigeo Yagi, Penny Clarke, Charles Y Chiu, Kenneth L Tyler
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006199 (2017)
In 2014, the United States experienced an epidemic of acute flaccid myelitis (AFM) cases in children coincident with a nationwide outbreak of enterovirus D68 (EV-D68) respiratory disease. Up to half of the 2014 AFM patients had EV-D68 RNA detected by
Externí odkaz:
https://doaj.org/article/0e7bdaf4fd244f19bf64edf7fda2fc98
Autor:
Joshua Frost, Michael J. Rudy, J. Smith Leser, Haozhou Tan, Yanmei Hu, Jun Wang, Penny Clarke, Kenneth L. Tyler
Publikováno v:
Journal of Virology. 97
Recent outbreaks of EV-D68 in 2014, 2016, and 2018 have resulted in over 600 cases of a paralytic illness that is known as AFM. AFM is a predominantly pediatric disease with no FDA-approved treatment, and many patients show minimal recovery from limb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a2cf9dba052ae86f398f6a620c447b4
https://doi.org/10.1128/jvi.00156-23
https://doi.org/10.1128/jvi.00156-23
Autor:
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. Boyd, Kenneth L. Tyler
Publikováno v:
Journal of Virology. 97
Although rare, WNV encephalitis poses a devastating health concern, with few treatment options and frequent long-term neurological sequelae. Currently, there are no human vaccines or specific antivirals against WNV infections, so further research int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebfd44d8c9005a4d5189917818ea00a1
https://doi.org/10.1128/jvi.01805-22
https://doi.org/10.1128/jvi.01805-22
Autor:
Thomas Lane, Jianing Fu, Barbara Sherry, Bart Tarbet, Brett L. Hurst, Olga Riabova, Elena Kazakova, Anna Egorova, Penny Clarke, J. Smith Leser, Joshua Frost, Michael Rudy, Ken Tyler, Thomas Klose, Richard J. Kuhn, Vadim Makarov, Sean Ekins
Acute flaccid myelitis (AFM) leads to loss of limb control in young children and is likely due to Enterovirus-D68 (EV-D68), for which there is no current treatment. We have developed a lead isoxazole-3-carboxamide analog of pleconaril (11526092) whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cad8c10165826432c7f0693b4b90bbc
https://doi.org/10.1101/2021.12.24.474126
https://doi.org/10.1101/2021.12.24.474126
Publikováno v:
Journal of Virology. 95
Recruitment of immune cells from the periphery is critical for controlling West Nile virus (WNV) growth in the central nervous system (CNS) and preventing subsequent WNV-induced CNS disease. Neuroinflammatory responses, including the release of pro-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45cd169216e24a7791d394fc36809565
https://doi.org/10.1128/jvi.00835-21
https://doi.org/10.1128/jvi.00835-21
Reovirus encephalitis in mice was used as a model system to investigate astrocyte activation (astrogliosis) following viral infection of the brain. Reovirus infection resulted in astrogliosis, as evidenced by increased expression of glial fibrillary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf9404413ec1fc6cf6e5af67bad32a7
https://europepmc.org/articles/PMC6498044/
https://europepmc.org/articles/PMC6498044/
Publikováno v:
Journal of Virology. 90:7684-7691
The tumor suppressor p53 plays a critical part in determining cell fate both as a regulator of the transcription of several proapoptotic genes and through its binding interactions with Bcl-2 family proteins at mitochondria. We now demonstrate that p5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a04ba325a489c9d6f84017fae456b51
https://doi.org/10.1128/jvi.00583-16
https://doi.org/10.1128/jvi.00583-16
Autor:
Shigeo Yagi, Alison M. Hixon, Kenneth L. Tyler, Guixia Yu, Charles Y. Chiu, J. Smith Leser, Penny Clarke
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 2, p e1006199 (2017)
PLoS Pathogens, Vol 13, Iss 2, p e1006199 (2017)
In 2014, the United States experienced an epidemic of acute flaccid myelitis (AFM) cases in children coincident with a nationwide outbreak of enterovirus D68 (EV-D68) respiratory disease. Up to half of the 2014 AFM patients had EV-D68 RNA detected by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0d17efabeb5b5ae0c40f77c8f90862
http://europepmc.org/articles/PMC5322875
http://europepmc.org/articles/PMC5322875
Publikováno v:
Journal of Virology. 87:3447-3460
Reovirus infection is a well-characterized experimental system for the study of viral pathogenesis and antiviral immunity within the central nervous system (CNS). We have previously shown that c-Jun N-terminal kinase (JNK) and the Fas death receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69474180d8af403da0118af6c9db9fc7
https://doi.org/10.1128/jvi.02324-12
https://doi.org/10.1128/jvi.02324-12
Autor:
Roberta L. DeBiasi, Bridget A. Robinson, R. Dale Brown, J. Smith Leser, Penny Clarke, Carlin S. Long
Publikováno v:
Journal of Cardiac Failure. 16:901-910
Background Apoptosis of cardiac myocytes plays a key role in the pathogenesis of many cardiac diseases, including viral myocarditis. The apoptotic signaling pathways that are activated during viral myocarditis and the role that these pathways play in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62999b960cb120c4ea172a291c02979f
https://doi.org/10.1016/j.cardfail.2010.05.030
https://doi.org/10.1016/j.cardfail.2010.05.030