Zobrazeno 1 - 10
of 1 176
pro vyhledávání: '"J Slack"'
Autor:
Diego Galeano, Imrat, Jeffrey Haltom, Chaylen Andolino, Aliza Yousey, Victoria Zaksas, Saswati Das, Stephen B. Baylin, Douglas C. Wallace, Frank J. Slack, Francisco J. Enguita, Eve Syrkin Wurtele, Dorothy Teegarden, Robert Meller, Daniel Cifuentes, Afshin Beheshti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract MicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small molecules offers opportunities to modulate dysregulated cellular processes linked to diseases.
Externí odkaz:
https://doaj.org/article/f33890c2c4824222b8db02e8553313a4
Autor:
Eric Struth, Maryam Labaf, Vida Karimnia, Yiran Liu, Gwendolyn Cramer, Joanna B. Dahl, Frank J. Slack, Kourosh Zarringhalam, Jonathan P. Celli
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Interactions between tumor and stromal cells are well known to play prominent roles in progression of pancreatic ductal adenocarcinoma (PDAC). As knowledge of stromal crosstalk in PDAC has evolved, it has become clear that cancer associated
Externí odkaz:
https://doaj.org/article/9b02c2f9693f44e5a07a39320a2640fa
Autor:
Christos Miliotis, Yuling Ma, Xanthi-Lida Katopodi, Dimitra Karagkouni, Eleni Kanata, Kaia Mattioli, Nikolas Kalavros, Yered H. Pita-Juárez, Felipe Batalini, Varune R. Ramnarine, Shivani Nanda, Frank J. Slack, Ioannis S. Vlachos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The landscape of non-coding mutations in cancer progression and immune evasion is largely unexplored. Here, we identify transcrptome-wide somatic and germline 3′ untranslated region (3′-UTR) variants from 375 gastric cancer patients from
Externí odkaz:
https://doaj.org/article/7e900114ce37476b816c721095f77f00
Autor:
Paolo Comeglio, Giulia Guarnieri, Sandra Filippi, Ilaria Cellai, Gabriele Acciai, Ian Holyer, Fredrik Zetterberg, Hakon Leffler, Barbro Kahl-Knutson, Erica Sarchielli, Annamaria Morelli, Mario Maggi, Robert J. Slack, Linda Vignozzi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionGalectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that h
Externí odkaz:
https://doaj.org/article/63192e450fe54462bda8d9eeb27e6b81
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 136-139 (2023)
The Keystone Symposium ‘Small Regulatory RNAs: From Bench to Bedside’ was held in Santa Fe, New Mexico from May 1–4, 2022. The symposium was organized by Frank J. Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt, and brought together scienti
Externí odkaz:
https://doaj.org/article/bedea14fe23247d8aa50bf32d94633b4
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Severe COVID-19 leads to widespread transcriptomic changes in the human brain, mimicking diminished cognitive performance. As long noncoding RNAs (lncRNAs) play crucial roles in the regulation of gene expression, identification of the lncRNAs differe
Externí odkaz:
https://doaj.org/article/8e88a92ee8984811be2945ff6ba71bdb
Autor:
Vishal Kasina, Aniket Wahane, Chung-Hao Liu, Lin Yang, Mu-Ping Nieh, Frank J. Slack, Raman Bahal
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 271-283 (2023)
Many diseases, especially cancer, are caused by the abnormal expression of non-coding microRNAs (miRNAs), which regulate gene expression, leading to the development of miRNA-based therapeutics. Synthetic miRNA inhibitors have shown promising efficacy
Externí odkaz:
https://doaj.org/article/44603b949dd346f5bf4cfc4a46eb9487
Autor:
Jonathan D. Lee, Bridget L. Menasche, Maria Mavrikaki, Madison M. Uyemura, Su Min Hong, Nina Kozlova, Jin Wei, Mia M. Alfajaro, Renata B. Filler, Arne Müller, Tanvi Saxena, Ryan R. Posey, Priscilla Cheung, Taru Muranen, Yujing J. Heng, Joao A. Paulo, Craig B. Wilen, Frank J. Slack
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113478- (2023)
Summary: Coronavirus disease 2019 (COVID-19) remains a significant public health threat due to the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants to evade the immune system and cause breakthrough infections. Although
Externí odkaz:
https://doaj.org/article/fc5e40c8967549f19441624446c62419
Autor:
Claire Harrison, John Mascarenhas, Daniela Cilloni, Richard Schlenk, Brian Jacoby, Robert J Slack, Vassilios Aslanis, Bhupinder Singh, Bertil Lindmark, Srdan Verstovsek, Raajit K Rampal
Publikováno v:
HemaSphere, Vol 7, p e87048d4 (2023)
Externí odkaz:
https://doaj.org/article/62f833fe9a3d493fa9bb83c9fd449bd4
Autor:
Joseph Mabbitt, Ian D. Holyer, James A. Roper, Ulf J. Nilsson, Fredrik R. Zetterberg, Lynda Vuong, Alison C. Mackinnon, Anders Pedersen, Robert J. Slack
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundGalectin-3 (Gal-3) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been suggested to predict a poor response to immune checkpoint therapy with the anti-PD-1 monoclo
Externí odkaz:
https://doaj.org/article/83c29c8c1ad94a898306e72ffb5e9687