Zobrazeno 1 - 10
of 255
pro vyhledávání: '"J Sigrist"'
Publikováno v:
International Journal of Multiphysics, Vol 4, Iss 3 (2016)
Numerical simulation of Vortex-Induced-Vibrations (VIV) of a rigid circular elastically-mounted cylinder submitted to a fluid cross-flow has been extensively studied over the past decades, both experimentally and numerically, because of its theoretic
Externí odkaz:
https://doaj.org/article/001bb5f94255496eb795db12e360dac9
Publikováno v:
International Journal of Multiphysics, Vol 3, Iss 1 (2016)
The present paper is concerned with the numerical simulation of Magneto-Hydro-Dynamic (MHD) problems with industrial tools. MHD has receivedattention some twenty to thirty years ago as a possible alternative inpropulsion applications; MHD propelled s
Externí odkaz:
https://doaj.org/article/f40d66e26d1746ad835a48326761e25b
Autor:
J Sigrist
Publikováno v:
International Journal of Multiphysics, Vol 3, Iss 1 (2016)
The paper is concerned with the dynamic analysis of a nuclear reactor withfluid-structure interaction modelling. Various fluid-structure interactioneffects (inertial, elasto-acoustic coupling, confinement) are investigatedusing specific mathematical
Externí odkaz:
https://doaj.org/article/d3f8b98d04ff420d9cc70f74d5b980ff
Publikováno v:
Redox Biology, Vol 79, Iss , Pp 103454- (2025)
Neurodegenerative diseases typically emerge after an extended prodromal period, underscoring the critical importance of initiating interventions during the early stages of brain aging to enhance later resilience. Changes in presynaptic active zone pr
Externí odkaz:
https://doaj.org/article/781240cde2d7450f8e3ab1a7508a82e2
Autor:
Sarah Perry, Yifu Han, Chengjie Qiu, Chun Chien, Pragya Goel, Samantha Nishimura, Manisha Sajnani, Andreas Schmid, Stephan J. Sigrist, Dion Dickman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Presynaptic homeostatic plasticity adaptively enhances neurotransmitter release following diminished postsynaptic glutamate receptor functionality. Here the authors identify a calcium-independent signaling system where active CaMKII detects a short d
Externí odkaz:
https://doaj.org/article/b16888b1f1694fdcbc097bd374d5a869
Autor:
Niraja Ramesh, Marc Escher, Oriane Turrel, Janine Lützkendorf, Tanja Matkovic, Fan Liu, Stephan J Sigrist
Publikováno v:
eLife, Vol 12 (2023)
We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and
Externí odkaz:
https://doaj.org/article/4a356fa83da94f90a638c4488370f580
Autor:
Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, Marina Jendrach
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). In recent years, impairment of autophagy has been iden
Externí odkaz:
https://doaj.org/article/6ec625ec673842d59b1af73f89fb8e97
Autor:
Jelena Tadic, Julia Ring, Andrea Jerkovic, Selena Ristic, Marta Maglione, Jörn Dengjel, Stephan J. Sigrist, Tobias Eisenberg
Publikováno v:
Cell Stress, Vol 6, Iss 5, Pp 61-64 (2022)
Alzheimer’s disease (AD) is the most common form of dementia with millions of people affected worldwide. Pathophysiological manifestations of AD include the extracellular accumulation of amyloid beta (Abeta) pep-tides, products of the proteolytic c
Externí odkaz:
https://doaj.org/article/c44ddf419ff94f3e8badbc73098e7b34
Autor:
Julia Ring, Jelena Tadic, Selena Ristic, Michael Poglitsch, Martina Bergmann, Nemanja Radic, Dirk Mossmann, YongTian Liang, Marta Maglione, Andrea Jerkovic, Roozbeh Hajiraissi, Marcel Hanke, Victoria Küttner, Heimo Wolinski, Andreas Zimmermann, Lana Domuz Trifunović, Leonie Mikolasch, Daiana N Moretti, Filomena Broeskamp, Julia Westermayer, Claudia Abraham, Simon Schauer, Christopher Dammbrueck, Sebastian J Hofer, Mahmoud Abdellatif, Guido Grundmeier, Guido Kroemer, Ralf J Braun, Niklas Hansen, Cornelia Sommer, Mirjana Ninkovic, Sandra Seba, Patrick Rockenfeller, Friederike‐Nora Vögtle, Jörn Dengjel, Chris Meisinger, Adrian Keller, Stephan J Sigrist, Tobias Eisenberg, Frank Madeo
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-26 (2022)
Abstract Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD). However, the etiology of its noxious cellular effects remains elusive. In a combinatory genetic and proteomic approach using a yeast m
Externí odkaz:
https://doaj.org/article/4c65d2eea54842d29ae6240b593bf7ff
Autor:
Roman Altshuler, Michael J. Sigrist
Although scholarship in philosophy of action has grown in recent years, there has been little work explicitly dealing with the role of time in agency, a role with great significance for the study of action. As the articles in this collection demonstr
