Zobrazeno 1 - 10
of 1 482
pro vyhledávání: '"J Sigrist"'
Publikováno v:
Redox Biology, Vol 79, Iss , Pp 103454- (2025)
Neurodegenerative diseases typically emerge after an extended prodromal period, underscoring the critical importance of initiating interventions during the early stages of brain aging to enhance later resilience. Changes in presynaptic active zone pr
Externí odkaz:
https://doaj.org/article/781240cde2d7450f8e3ab1a7508a82e2
Autor:
Sarah Perry, Yifu Han, Chengjie Qiu, Chun Chien, Pragya Goel, Samantha Nishimura, Manisha Sajnani, Andreas Schmid, Stephan J. Sigrist, Dion Dickman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Presynaptic homeostatic plasticity adaptively enhances neurotransmitter release following diminished postsynaptic glutamate receptor functionality. Here the authors identify a calcium-independent signaling system where active CaMKII detects a short d
Externí odkaz:
https://doaj.org/article/b16888b1f1694fdcbc097bd374d5a869
Autor:
Niraja Ramesh, Marc Escher, Oriane Turrel, Janine Lützkendorf, Tanja Matkovic, Fan Liu, Stephan J Sigrist
Publikováno v:
eLife, Vol 12 (2023)
We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and
Externí odkaz:
https://doaj.org/article/4a356fa83da94f90a638c4488370f580
Autor:
Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, Marina Jendrach
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). In recent years, impairment of autophagy has been iden
Externí odkaz:
https://doaj.org/article/6ec625ec673842d59b1af73f89fb8e97
Autor:
Jelena Tadic, Julia Ring, Andrea Jerkovic, Selena Ristic, Marta Maglione, Jörn Dengjel, Stephan J. Sigrist, Tobias Eisenberg
Publikováno v:
Cell Stress, Vol 6, Iss 5, Pp 61-64 (2022)
Alzheimer’s disease (AD) is the most common form of dementia with millions of people affected worldwide. Pathophysiological manifestations of AD include the extracellular accumulation of amyloid beta (Abeta) pep-tides, products of the proteolytic c
Externí odkaz:
https://doaj.org/article/c44ddf419ff94f3e8badbc73098e7b34
Autor:
Julia Ring, Jelena Tadic, Selena Ristic, Michael Poglitsch, Martina Bergmann, Nemanja Radic, Dirk Mossmann, YongTian Liang, Marta Maglione, Andrea Jerkovic, Roozbeh Hajiraissi, Marcel Hanke, Victoria Küttner, Heimo Wolinski, Andreas Zimmermann, Lana Domuz Trifunović, Leonie Mikolasch, Daiana N Moretti, Filomena Broeskamp, Julia Westermayer, Claudia Abraham, Simon Schauer, Christopher Dammbrueck, Sebastian J Hofer, Mahmoud Abdellatif, Guido Grundmeier, Guido Kroemer, Ralf J Braun, Niklas Hansen, Cornelia Sommer, Mirjana Ninkovic, Sandra Seba, Patrick Rockenfeller, Friederike‐Nora Vögtle, Jörn Dengjel, Chris Meisinger, Adrian Keller, Stephan J Sigrist, Tobias Eisenberg, Frank Madeo
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-26 (2022)
Abstract Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD). However, the etiology of its noxious cellular effects remains elusive. In a combinatory genetic and proteomic approach using a yeast m
Externí odkaz:
https://doaj.org/article/4c65d2eea54842d29ae6240b593bf7ff
Autor:
Roman Altshuler, Michael J. Sigrist
Although scholarship in philosophy of action has grown in recent years, there has been little work explicitly dealing with the role of time in agency, a role with great significance for the study of action. As the articles in this collection demonstr
Publikováno v:
PLoS Biology, Vol 20, Iss 12, p e3001730 (2022)
The brain as a central regulator of stress integration determines what is threatening, stores memories, and regulates physiological adaptations across the aging trajectory. While sleep homeostasis seems to be linked to brain resilience, how age-assoc
Externí odkaz:
https://doaj.org/article/2147b99477634435a4e7186b7ea6ca41
Autor:
Atefeh Pooryasin, Marta Maglione, Marco Schubert, Tanja Matkovic-Rachid, Sayed-mohammad Hasheminasab, Ulrike Pech, André Fiala, Thorsten Mielke, Stephan J. Sigrist
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The physical distance between synaptic Ca2+ channels and sensors modulates short-term plasticity (STP). Here, the authors show that synaptic release factors Unc13A and Unc13B distinctly couple with Ca2+ channels and contribute to the neural decoding
Externí odkaz:
https://doaj.org/article/1555961b6bb840d7b6165c99930a8b08
Autor:
Chengji Piao, Stephan J. Sigrist
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2022)
The so-called active zones at pre-synaptic terminals are the ultimate filtering devices, which couple between action potential frequency and shape, and the information transferred to the post-synaptic neurons, finally tuning behaviors. Within active
Externí odkaz:
https://doaj.org/article/b4af6fe7df4b43db80f42ad0bdddb2e5