Zobrazeno 1 - 10
of 103
pro vyhledávání: '"J Shaun, Lott"'
Autor:
Jason N. Busby, Sarah Trevelyan, Cassandra L. Pegg, Edward D. Kerr, Benjamin L. Schulz, Irene Chassagnon, Michael J. Landsberg, Mitchell K. Weston, Mark R. H. Hurst, J. Shaun Lott
Publikováno v:
IUCrJ, Vol 11, Iss 3, Pp 299-308 (2024)
Bacterial ABC toxin complexes (Tcs) comprise three core proteins: TcA, TcB and TcC. The TcA protein forms a pentameric assembly that attaches to the surface of target cells and penetrates the cell membrane. The TcB and TcC proteins assemble as a hete
Externí odkaz:
https://doaj.org/article/dcb2f060e5bd4484b41d76245489dbbd
Autor:
Sarah J Piper, Lou Brillault, Rosalba Rothnagel, Tristan I Croll, Joseph K Box, Irene Chassagnon, Sebastian Scherer, Kenneth N Goldie, Sandra A Jones, Femke Schepers, Lauren Hartley-Tassell, Thomas Ve, Jason N Busby, Julie E Dalziel, J Shaun Lott, Ben Hankamer, Henning Stahlberg, Mark R H Hurst, Michael J Landsberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
YenTcA is the pore-forming and membrane binding subunit of the ABC toxin YenTc, which is produced by the insect pathogen Yersinia entomophaga. Here authors present cryo-EM structures of YenTcA purified from the native source which implicate associate
Externí odkaz:
https://doaj.org/article/22ed524a9e8c453c8589dc7718c89ba1
Autor:
Reuben McGregor, Alana L. Whitcombe, Campbell R. Sheen, James M. Dickson, Catherine L. Day, Lauren H. Carlton, Prachi Sharma, J. Shaun Lott, Barbara Koch, Julie Bennett, Michael G. Baker, Stephen R. Ritchie, Shivani Fox-Lewis, Susan C. Morpeth, Susan L. Taylor, Sally A. Roberts, Rachel H. Webb, Nicole J. Moreland
Publikováno v:
PeerJ, Vol 8, p e9863 (2020)
Background Serological assays that detect antibodies to SARS-CoV-2 are critical for determining past infection and investigating immune responses in the COVID-19 pandemic. We established ELISA-based immunoassays using locally produced antigens when N
Externí odkaz:
https://doaj.org/article/f4d51d459e1742a5b2037cdfc57a8dd8
Autor:
Genevieve L. Evans, Daniel P. Furkert, Nacim Abermil, Preeti Kundu, Katrina M. de Lange, Emily J. Parker, Margaret A. Brimble, Edward N. Baker, J. Shaun Lott
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 1019-1029 (2017)
There are twenty-five published structures of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (Mtb-AnPRT) that use the same crystallization protocol. The structures include protein complexed with natural and alternative substrates,
Externí odkaz:
https://doaj.org/article/5c6539f806014fd3a63a51b4a3d201bc
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Pioneering bioinformatic analysis using sequence data revealed that teneurins evolved from bacterial tyrosine-aspartate (YD)-repeat protein precursors. Here, we discuss how structures of the C-terminal domain of teneurins, determined using X-ray crys
Externí odkaz:
https://doaj.org/article/32b4737568c540509e230911e65f3824
Autor:
Michael D Healy, Manuela K Hospenthal, Ryan J Hall, Mintu Chandra, Molly Chilton, Vikas Tillu, Kai-En Chen, Dion J Celligoi, Fiona J McDonald, Peter J Cullen, J Shaun Lott, Brett M Collins, Rajesh Ghai
Publikováno v:
eLife, Vol 7 (2018)
The COMMD proteins are a conserved family of proteins with central roles in intracellular membrane trafficking and transcription. They form oligomeric complexes with each other and act as components of a larger assembly called the CCC complex, which
Externí odkaz:
https://doaj.org/article/52ef44e3fdd642e78e446da5ae0c2ac6
Publikováno v:
Acta Crystallogr F Struct Biol Commun
The Ca2+-dependent enzyme peptidyl-arginine deiminase type III (PAD3) catalyses the deimination of arginine residues to form citrulline residues in proteins such as keratin, filaggrin and trichohyalin. This is an important post-translation modificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b11715016b548b16345660b36be8a2d
https://doi.org/10.1107/s2053230x21009195
https://doi.org/10.1107/s2053230x21009195
Autor:
J. Shaun Lott
Publikováno v:
Biochemical Society Transactions
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is the most significant cause of death from a single infectious agent worldwide. Antibiotic-resistant strains of M. tuberculosis represent a threat to effective treatment, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1034dce8aa9c19f888c86d6eedebd5
http://europepmc.org/articles/PMC7609029
http://europepmc.org/articles/PMC7609029
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F1-F13
Renal Na+reabsorption, facilitated by the epithelial Na+channel (ENaC), is subject to multiple forms of control to ensure optimal body blood volume and pressure through altering both the ENaC population and activity at the cell surface. Here, the foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::351a724086fecda5e1b3ae53c46d83e7
https://doi.org/10.1152/ajprenal.00277.2019
https://doi.org/10.1152/ajprenal.00277.2019
Autor:
James M. J. Dickson, Alana L. Whitcombe, Sally A Roberts, Rachel Webb, Campbell R. Sheen, Barbara Koch, Catherine L. Day, Susan C. Morpeth, Lauren H Carlton, Nicole J. Moreland, Shivani Fox-Lewis, Reuben McGregor, Michael G Baker, Julie Bennett, Susan Taylor, J. Shaun Lott, Stephen R Ritchie, Prachi Sharma
Publikováno v:
PeerJ, Vol 8, p e9863 (2020)
PeerJ, Ahead of
PeerJ
PeerJ, Ahead of
PeerJ
Background Serological assays that detect antibodies to SARS-CoV-2 are critical for determining past infection and investigating immune responses in the COVID-19 pandemic. We established ELISA-based immunoassays using locally produced antigens when N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe49836b9f536c99488edf1a225b6f3f
https://peerj.com/articles/9863.pdf
https://peerj.com/articles/9863.pdf