Zobrazeno 1 - 10
of 153
pro vyhledávání: '"J Scott Daniels"'
Autor:
Timothy P Ryan, Ryan D Morrison, Jeffrey J Sutherland, Stephen B Milne, Kendall A Ryan, J Scott Daniels, Anita Misra-Hebert, J Kevin Hicks, Eric Vogan, Kathryn Teng, Thomas M Daly
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185471 (2017)
Poor adherence to medication regimens and medical record inconsistencies result in incomplete knowledge of medication therapy in polypharmacy patients. By quantitatively identifying medications in the blood of patients and reconciling detected medica
Externí odkaz:
https://doaj.org/article/0973a9f4d787461a9943d9d16cb0f75a
Autor:
Mark Rolfe, Julie X. Zhang, Gabriel S. Weatherhead, Christopher A. Tsu, Yuan Tian, Matthew Stirling, Marjorie S. Solomon, Corinne L. Reimer, Ashok D. Patil, Anne M. Mazzola, Jason Labutti, Lawrence R. Dick, J. Scott Daniels, Yueying Cao, Frank J. Bruzzese, Jonathan L. Blank, Mark J. Williamson
Supplementary Fig. S2 from Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d6b3c01afa13c5032c97a247196bc9
https://doi.org/10.1158/1535-7163.22484490
https://doi.org/10.1158/1535-7163.22484490
Autor:
Mark Rolfe, Julie X. Zhang, Gabriel S. Weatherhead, Christopher A. Tsu, Yuan Tian, Matthew Stirling, Marjorie S. Solomon, Corinne L. Reimer, Ashok D. Patil, Anne M. Mazzola, Jason Labutti, Lawrence R. Dick, J. Scott Daniels, Yueying Cao, Frank J. Bruzzese, Jonathan L. Blank, Mark J. Williamson
Supplementary Table S1 from Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e3daae3978bdef7d650a92159c9248
https://doi.org/10.1158/1535-7163.22484487.v1
https://doi.org/10.1158/1535-7163.22484487.v1
Autor:
Changho Han, J. Scott Daniels, Alice L. Rodriguez, Colleen M. Niswender, Alison R. Gregro, P. Jeffrey Conn, Michael R. Wood, Craig W. Lindsley, Katrina A. Bollinger, Michael W. Wood, Mark E. Duggan, Sichen Chang, Darren W. Engers, Atin Lamsal, Ryan D. Morrison, Andrew S. Felts, Trevor C. Chopko, Nicholas J. Brandon, Nathalie Schnetz-Boutaud, Vincent B. Luscombe, Hyekyung P. Cho, Mike Poslusney, Carrie K. Jones, Donald F. Stec, Thomas M. Bridges, Michael Bubser, Bruce J. Melancon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2224-2228
This letter describes progress towards an M4 PAM preclinical candidate inspired by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant thieno[2,3-c]pyridine core to an equipotent, non-CNS penetrant thieno[2,3-c]pyrdin-7(6H)-one c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c29ef3365adcf94a1df6de7318989723
https://doi.org/10.1016/j.bmcl.2019.06.032
https://doi.org/10.1016/j.bmcl.2019.06.032
Autor:
J. Scott Daniels, Christopher J. Brassard, Ryan D. Morrison, Alice L. Rodriguez, Anna L. Blobaum, Kyle A. Emmitte, Andrew S. Felts, P. Jeffrey Conn, Colleen M. Niswender, Carrie K. Jones, Katrina A. Bollinger, Craig W. Lindsley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:47-50
This letter describes the further chemical optimization of VU0424238 (auglurant), an mGlu5 NAM clinical candidate that failed in non-human primate (NHP) 28 day toxicology due to accumulation of a species-specific aldehyde oxidase (AO) metabolite of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb482b3f7ed5d8ceff7652d52cf789b
https://doi.org/10.1016/j.bmcl.2018.11.017
https://doi.org/10.1016/j.bmcl.2018.11.017
Autor:
Alice L. Rodriguez, Anna L. Blobaum, Frank W. Byers, Ryan D. Morrison, P. Jeffrey Conn, Colleen M. Niswender, J. Scott Daniels, Craig W. Lindsley, Kyle A. Emmitte, Andrew S. Felts
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1679-1685
Based on previous work that established fused heterocycles as viable alternatives for the picolinamide core of our lead series of mGlu(5) negative allosteric modulators (NAMs), we designed a novel series of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ab16f07b7a5acc4095bd91a4875f3f
https://doi.org/10.1016/j.bmcl.2018.04.053
https://doi.org/10.1016/j.bmcl.2018.04.053
Autor:
J. Scott Daniels, Swagat Sharma, Joshua M. Wieting, Corey R. Hopkins, Kristopher K. Abney, Kevin Wickman, Anish K. Vadukoot, Thomas M. Bridges, Ryan D. Morrison, C. David Weaver
Publikováno v:
ACS Chemical Neuroscience. 8:1873-1879
The G protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) are a family of inward-rectifying potassium channels, and there is significant evidence supporting the roles of GIRKs in a number of physiological processes and as potential targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bb0c75f09e6e32acc76c60b4c71f62
https://doi.org/10.1021/acschemneuro.7b00217
https://doi.org/10.1021/acschemneuro.7b00217
Publikováno v:
ACS Chemical Neuroscience. 8:1641-1644
There are multiple treatment options for depression, anxiety, psychosis, and other psychiatric disorders, and psychiatry patients are often comorbid with complex, polypharmacy treatment regimens. Unlike cardiovascular disease and diabetes, there are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e46a5b9165f9df7387236159204b135
https://doi.org/10.1021/acschemneuro.7b00209
https://doi.org/10.1021/acschemneuro.7b00209
Publikováno v:
Xenobiotica. 48:219-231
1. Failure to predict human pharmacokinetics of aldehyde oxidase (AO) substrates using traditional allometry has been attributed to species differences in AO metabolism. 2. To identify appropriate species for predicting human in vivo clearance by sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0ca8dfe2f0bc47a29b407fb2c13971
https://doi.org/10.1080/00498254.2017.1296208
https://doi.org/10.1080/00498254.2017.1296208
Autor:
Trevor C, Chopko, Changho, Han, Alison R, Gregro, Darren W, Engers, Andrew S, Felts, Mike S, Poslusney, Katrina A, Bollinger, Ryan D, Morrison, Michael, Bubser, Atin, Lamsal, Vincent B, Luscombe, Hyekyung P, Cho, Nathalie C, Schnetz-Boutaud, Alice L, Rodriguez, Sichen, Chang, J Scott, Daniels, Donald F, Stec, Colleen M, Niswender, Carrie K, Jones, Michael R, Wood, Michael W, Wood, Mark E, Duggan, Nicholas J, Brandon, P Jeffrey, Conn, Thomas M, Bridges, Craig W, Lindsley, Bruce J, Melancon
Publikováno v:
Bioorg Med Chem Lett
This letter describes progress towards an M(4) PAM preclinical candidate driven by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant thieno[2,3-c]pyridine core to an equipotent, non-CNS penetrant thieno[2,3-c]pyrdin-7(6H)-one c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4069dcd12947a73a119ed46b5a9d3756
https://pubmed.ncbi.nlm.nih.gov/31248774
https://pubmed.ncbi.nlm.nih.gov/31248774