Zobrazeno 1 - 10
of 89
pro vyhledávání: '"J Santora"'
Publikováno v:
IEEE Sensors Journal. 22:6964-6974
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc16cd7abffa0e3e9b630114f44fd9a7
https://doi.org/10.1109/jsen.2022.3154980
https://doi.org/10.1109/jsen.2022.3154980
Autor:
Kiev S. Ly, Andrew Richard Hudson, Christine Hoffmaster, James T. Limberis, J. Guy Breitenbucher, Richard Barido, De Michael Chung, Yingzhuo Yan, Gary Anderson, Vincent J. Santora, Dany Gitnick, Dong Lee, Brett C. Bookser, Anne Danks, Robert E. Petroski, Graeme Freestone, Varsha Gupta, Clifford Cabebe, Andrew Morse, Michael R. Kennedy, Kristen Sebring, Zachary W. Yoder, Douglas Zook, Marco Peters, Chih-Kun Chai, Joel Renick, Jim Na, Theresa A. Almos, Shouzhen Xia, Ali Tabatabaei, John Nikpur, Samantha Sevidal, Stephine Chow, Mi Chen, Jillian Basinger, Chris L. Bellows, Lindsay Heger, David Neul, Jenny Wen, Brittany Masatsugu, Nicola J. Broadbent, Alan P. Kaplan, Chi Ching Mak
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
A strategy to conformationally restrain a series of GlyT1 inhibitors identified potent analogs that exhibited slowly interconverting rotational isomers. Further studies to address this concern led to a series of azetidine-based inhibitors. Compound 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912579fcc2f963bd82182bdd275301b0
https://pubmed.ncbi.nlm.nih.gov/32527538
https://pubmed.ncbi.nlm.nih.gov/32527538
Autor:
David Neul, Andrew Morse, Joel Renick, Brittany Masatsugu, Chi Ching Mak, James T. Limberis, Dany Gitnick, Zachary W. Yoder, Michael R. Kennedy, Kiev S. Ly, Samantha Sevidal, Richard Barido, Robert E. Petroski, Graeme Freestone, Clifford Cabebe, Jillian Basinger, Vincent J. Santora, Christine Hoffmaster, Chris L. Bellows, Yingzhuo Yan, Mi Chen, De Michael Chung, John Nikpur, Kristen Sebring, Jenny Wen, Ali Tabatabaei, Brett C. Bookser, Theresa A. Almos, Andrew Richard Hudson, J. Guy Breitenbucher, Chih-Kun Chai, Dong Lee, Lindsay Crickard, Anne Danks, Varsha Gupta, Marco Peters, Alan P. Kaplan, Jim Na, Nicola J. Broadbent, Stephine Chow, Douglas Zook
Publikováno v:
Journal of Medicinal Chemistry. 61:6018-6033
We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4- c]pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3769bd94e72c5343ca6a4bb3a9739f64
https://doi.org/10.1021/acs.jmedchem.8b00372
https://doi.org/10.1021/acs.jmedchem.8b00372
Autor:
Jeffrey Vivian, Ali Tabatabaei, Mi Chen, Lindsay Heger, Vincent J. Santora, Chung Demichael, Terence P. Keenan, James Guy Breitenbucher, Jie Chen, Joel Renick, Douglas Zook, Trevor Scott, Guibao Gu, Kathe Stauber
Publikováno v:
Neurochemistry International. 137:104735
Phosphodiesterase 7B (PDE7B) inhibition has been considered as a therapeutic target for the treatment of several neurological disorders. Currently, there are no radio-labeled tracers available to determine receptor occupancy (RO) of this target. Deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0931dae78e13249d61dbd2990bb2eb1e
https://doi.org/10.1016/j.neuint.2020.104735
https://doi.org/10.1016/j.neuint.2020.104735
Publikováno v:
SAE Technical Paper Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95dae9bf0939e9a3597f104a11cec2f0
https://doi.org/10.4271/2017-01-1827
https://doi.org/10.4271/2017-01-1827
Autor:
Daniel E. Abbott, Thinh Vu, Rachel J. Santora, Scott B. Cantor, Henry F. Gomez, Nancy D. Perrier, Elizabeth G. Grubbs, Jeffrey E. Lee, Douglas B. Evans
Publikováno v:
Journal of the American College of Surgeons. 214:629-637
Preoperative imaging in patients with primary hyperparathyroidism provides important localization information. Although 4-dimensional neck CT (4DCT) can precisely localize hyperfunctioning parathyroid tissue, the contribution of 4DCT to overall cost,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258ffa58e4f2e95b59047c4e6673a6d8
https://doi.org/10.1016/j.jamcollsurg.2011.12.022
https://doi.org/10.1016/j.jamcollsurg.2011.12.022
Autor:
Brian M. Smith, Marissa Suarez, Douglas M. Park, Graeme Semple, Rena Hayashi, Jonathan A. Covel, Andrew J. Grottick, Jeffrey A. Schultz, Erin K. Hauser, Brian J. Hofilena, John Frazer, Vincent J. Santora, Jeff Edwards, Jason B. Ibarra, Jodie Lorea, Albert S. Ren, Scott A. Estrada, Ryan M. Hart, Jeffrey Smith, Charlemagne S. Gallardo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:71-75
The design of a new clinical candidate histamine-H(3) receptor antagonist for the potential treatment of excessive daytime sleepiness (EDS) is described. Phenethyl-R-2-methylpyrrolidine containing biphenylsulfonamide compounds were modified by replac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d0d99a5060605090b0ee3524c5cbb2d
https://doi.org/10.1016/j.bmcl.2011.11.075
https://doi.org/10.1016/j.bmcl.2011.11.075
Publikováno v:
Molecular and Cellular Biochemistry. 347:191-199
We previously demonstrated that enteral arginine increased c-Jun/activator protein-1 (AP-1) DNA-binding activity and iNOS expression in a rodent model of mesenteric ischemia/reperfusion (I/R). The objective of this study was to specifically investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f3872c6f4300919c0d834c3660241d
https://doi.org/10.1007/s11010-010-0628-x
https://doi.org/10.1007/s11010-010-0628-x
Autor:
Rachel J. Santora, Rosemary A. Kozar
Publikováno v:
Journal of Surgical Research. 161:288-294
Nutritional supplementation has become the standard of care for management of critically ill patients. Traditionally, nutritional support in this patient population was intended to replete substrate deficiencies secondary to stress-induced catabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af946e2aa1b3f44fb68103164245a88
https://doi.org/10.1016/j.jss.2009.06.024
https://doi.org/10.1016/j.jss.2009.06.024
Publikováno v:
The Annals of Thoracic Surgery. 89:931-937
Background Esophageal or gastric leakage from anastomotic wound dehiscence, perforation, staple line dehiscence, or trauma can be a devastating event. Traditional therapy has often consisted of either surgical repair for rapidly diagnosed leaks or di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e545fca5d93f5316e8875f7608751c7f
https://doi.org/10.1016/j.athoracsur.2009.10.061
https://doi.org/10.1016/j.athoracsur.2009.10.061