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Exacerbated Transplant Arteriosclerosis in Inducible Nitric Oxide–Deficient Mice

Autor: J. S. Mudgett, Jörg Koglin, Mary E. Russell, Troels Glysing-Jensen

Publikováno v: Circulation. 97:2059-2065

Background —Inducible NO synthase (NOS2, or iNOS) is upregulated in grafts with transplant arteriosclerosis. However, the functional role of NOS2 in the pathogenesis of transplant arteriosclerosis remains unclear. NOS2 may regulate lesion developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9c22054ab0afc7e800e68f3cf637b7
https://doi.org/10.1161/01.cir.97.20.2059

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Human ERCC5 cDNA-cosmid complementation for excision repair and bipartite amino acid domains conserved with RAD proteins of Saccharomyces cerevisiae and Schizosaccharomyces pombe

Autor: R J Reynolds, J A Dickson, Gary F. Strniste, Min S. Park, J S Mudgett, Mark A. MacInnes, D Learmonth, R R Hernandez, S Schauer, G Y Lin

Publikováno v: Molecular and Cellular Biology. 13:6393-6402

Several human genes related to DNA excision repair (ER) have been isolated via ER cross-species complementation (ERCC) of UV-sensitive CHO cells. We have now isolated and characterized cDNAs for the human ERCC5 gene that complement CHO UV135 cells. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4a8a2723b1f2d8dd6fd21e96a3cd1d4
https://doi.org/10.1128/mcb.13.10.6393

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Recombination between Irradiated Shuttle Vector DNA and Chromosomal DNA in African Green Monkey Kidney Cells

Autor: J S Mudgett, W D Taylor

Publikováno v: Molecular and Cellular Biology. 10:37-46

An autonomously replicating shuttle vector was used to investigate enhancement of plasmid-chromosome recombination in mammalian host cells by gamma irradiation and UV light. Sequences homologous to the shuttle vector were stably inserted into the gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf77ca7891a75785df927ba7491c004
https://doi.org/10.1128/mcb.10.1.37-46.1990

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NOS2 mediates opposing effects in models of acute and chronic cardiac rejection: insights from NOS2-knockout mice

Autor: J, Koglin, T, Glysing-Jensen, J S, Mudgett, M E, Russell

Publikováno v: The American journal of pathology. 153(5)

To compare regulatory effects of NOS2 in acute and chronic cardiac allograft rejection, we used NOS2 knockout mice as recipients in a cardiac transplant model. To study acute and chronic rejection separately but within the same genetic strain combina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16c988b3fc8d88e0764a4ff6b3778197
https://pubmed.ncbi.nlm.nih.gov/9811327

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Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene

Autor: J E, Fenyk-Melody, A E, Garrison, S R, Brunnert, J R, Weidner, F, Shen, B A, Shelton, J S, Mudgett

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(6)

Nitric oxide is believed to be a prominent mediator of inflammation based in part on the correlative expression of the inducible nitric oxide synthase (iNOS) gene in various pathologies. The resulting high output of the highly reactive molecule nitri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7acec66c95bba669131177ef3fd69049
https://pubmed.ncbi.nlm.nih.gov/9510198

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Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction

Autor: J S, Mudgett, N I, Hutchinson, N A, Chartrain, A J, Forsyth, J, McDonnell, I I, Singer, E K, Bayne, J, Flanagan, D, Kawka, C F, Shen, K, Stevens, H, Chen, M, Trumbauer, D M, Visco

Publikováno v: Arthritis and rheumatism. 41(1)

It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This hypothesis was tested by examining the arthritic paw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2e3a86f5cb5e87a1c9cdc6022209701
https://pubmed.ncbi.nlm.nih.gov/9433876

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Molecular cloning and structural analysis of the functional mouse genomic XPG gene

Autor: J. S. Mudgett, Mark A. MacInnes, Min S. Park, A. V. Perez-Castro, Dale L. Ludwig

Publikováno v: Mammalian genome : official journal of the International Mammalian Genome Society. 7(9)

The mouse XPG gene is a homolog of the human DNA excision repair gene known to be defective in the hereditary sun-sensitive disorder xeroderma pigmentosum (group-G). Defects in mouse XPG have been shown to directly affect the sensitivity of cultured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f86cfe0f529a9497d78fb234685dcd
https://pubmed.ncbi.nlm.nih.gov/8703115

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Homologous recombination and mutagenesis of gamma-irradiated plasmid DNA in Escherichia coli host cells

Autor: J S, Mudgett, J M, Manzella, W D, Taylor

Publikováno v: Radiation research. 124(1)

Plasmid DNA was used to study gamma-radiation-induced recombination and mutagenesis in Escherichia coli host cells. Plasmid pBRP1, a derivative of pBR322 containing the lac operon of E. coli, was irradiated with 60Co gamma rays prior to transformatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24ba7c4a3d90f4172bf2d67a6ac2ea06
https://pubmed.ncbi.nlm.nih.gov/2236496

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