Zobrazeno 1 - 10
of 166
pro vyhledávání: '"J S Mudgett"'
Publikováno v:
Circulation. 97:2059-2065
Background —Inducible NO synthase (NOS2, or iNOS) is upregulated in grafts with transplant arteriosclerosis. However, the functional role of NOS2 in the pathogenesis of transplant arteriosclerosis remains unclear. NOS2 may regulate lesion developme
Autor:
R J Reynolds, J A Dickson, Gary F. Strniste, Min S. Park, J S Mudgett, Mark A. MacInnes, D Learmonth, R R Hernandez, S Schauer, G Y Lin
Publikováno v:
Molecular and Cellular Biology. 13:6393-6402
Several human genes related to DNA excision repair (ER) have been isolated via ER cross-species complementation (ERCC) of UV-sensitive CHO cells. We have now isolated and characterized cDNAs for the human ERCC5 gene that complement CHO UV135 cells. T
Autor:
J S Mudgett, W D Taylor
Publikováno v:
Molecular and Cellular Biology. 10:37-46
An autonomously replicating shuttle vector was used to investigate enhancement of plasmid-chromosome recombination in mammalian host cells by gamma irradiation and UV light. Sequences homologous to the shuttle vector were stably inserted into the gen
Publikováno v:
The American journal of pathology. 153(5)
To compare regulatory effects of NOS2 in acute and chronic cardiac allograft rejection, we used NOS2 knockout mice as recipients in a cardiac transplant model. To study acute and chronic rejection separately but within the same genetic strain combina
Autor:
J E, Fenyk-Melody, A E, Garrison, S R, Brunnert, J R, Weidner, F, Shen, B A, Shelton, J S, Mudgett
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(6)
Nitric oxide is believed to be a prominent mediator of inflammation based in part on the correlative expression of the inducible nitric oxide synthase (iNOS) gene in various pathologies. The resulting high output of the highly reactive molecule nitri
Autor:
J S, Mudgett, N I, Hutchinson, N A, Chartrain, A J, Forsyth, J, McDonnell, I I, Singer, E K, Bayne, J, Flanagan, D, Kawka, C F, Shen, K, Stevens, H, Chen, M, Trumbauer, D M, Visco
Publikováno v:
Arthritis and rheumatism. 41(1)
It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This hypothesis was tested by examining the arthritic paw
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 7(9)
The mouse XPG gene is a homolog of the human DNA excision repair gene known to be defective in the hereditary sun-sensitive disorder xeroderma pigmentosum (group-G). Defects in mouse XPG have been shown to directly affect the sensitivity of cultured
Publikováno v:
Radiation research. 124(1)
Plasmid DNA was used to study gamma-radiation-induced recombination and mutagenesis in Escherichia coli host cells. Plasmid pBRP1, a derivative of pBR322 containing the lac operon of E. coli, was irradiated with 60Co gamma rays prior to transformatio
Autor:
M A, MacInnes, J S, Mudgett
Publikováno v:
Progress in clinical and biological research.
Publikováno v:
Journal of the American College of Cardiology. 31:1