Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling

Autor: Matthew J. Elder, Steve J. Webster, Timothy J. Fitzmaurice, Aran S. D. Shaunak, Martin Steinmetz, Ronnie Chee, Ziad Mallat, E. Suzanne Cohen, David L. Williams, J. S. Hill Gaston, Jane C. Goodall

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases. TSLP is produced by many cell types, but has predominantly been characterized as a

Externí odkaz: https://doaj.org/article/d37c0112f5e9441b8aa4a1a774e80bea

Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia Molecules.

Autor: Claudia Prevosto, M Farooq Usmani, Sarah McDonald, Aleksandra M Gumienny, Tim Key, Reyna S Goodman, J S Hill Gaston, Michael J Deery, Robert Busch

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0161011 (2016)

Major histocompatibility complex class I (MHCI) glycoproteins present cytosolic peptides to CD8+ T cells and regulate NK cell activity. Their heavy chains (HC) are expressed from up to three MHC gene loci (human leukocyte antigen [HLA]-A, -B, and -C

Externí odkaz: https://doaj.org/article/b141584561f949a092063cb993a5045a

Spondylarthropathies (including psoriatic arthritis): 244. Validity of Colour Doppler and Spectral Doppler Ultrasound of Sacroilicac Joints Againts Physical Examination as Gold Standard

Autor: Jackie Shaw, Christoph Renner, Waji Hassan, Robert Landewé, Carmel B. Stober, Aruna S. Malipeddi, Karen Obrenovic, Paul Creamer, Ramesh N. Jois, Katilin DiGleria, Peter Lanyon, Y. Wang, Simon Kollnberger, Leticia Lojo-Oliveira, A. Baratelle, for Assert Go-Raise Investigators, Michele Olds, Claire Sheehy, D. van der Heijde, Michael J. Green, Lotta Utriainen, Charlotte Cavill, Frances Rees, Karen Mills, N. Kerrigan, J. S. Hill Gaston, Claudia Prevosto, M. Mack, J. Braun, Philip S. Helliwell, Sravan Payeli, P. Geusens, R. Inman, Lucy Coates, S. Xu, Sarah McDonald, Paul Bowness, S. Mudivarthy, Emilio Martín-Mola, Kaushik Sanyal, Gordon Taylor, Chandra Chattopadhyay, D. Gladman, A. Beutler, Tim Key, Philip J. Mease, Paul Emery, J. Sieper, Yasser El Miedany, Frederic Lavie, Jonathan Packham, Concepción Castillo-Gallego, B. Dijkmans, Joanna L. Giles, Rebecca Neame, Cynthia Wright, Benoit Guerette, Reyna Goodman, Alessandra De Riva, Ashok K. Bhalla, Miriam García-Arias, David G. I. Scott, M. U. Rahman, Osiris Marroquin, Roman Fischer, Helen Benham, Helen MakIver, Sarah Hailwood, Katsumi Maenaka, N. Goldstein, A Brooksby, Jon Packham, W. Xu, Christopher T. Ritchlin, Deborah Palmer, Ravinder Sandhu, A. Kavanaugh, Iain B. McInnes, Kirsty McHugh, William Tillett, Karl Gaffney, A. Deodhar, N. Vastesaeger, Michael J. Deery, J. Zrubek, Robert Busch, Jane C. Goodall, Neil McHugh, Sonja Kary, P. Mease, Philip G. Conaghan, Hartmut Kupper, G. G. Krueger, Chamaida Plasencia-Rodríguez, Eugenio de Miguel Mendieta, Gamal Ibrahim, Gill Peffers, James Francis, J. Leeder, Carolyn Bell, E. Korendowych, Benedikt M. Kessler, Louise Hamilton, Nicola Erb, Jacqueline Shaw, Margaret Somerville, Karen Walker-Bone, Simon Milling, Laura C. Coates, B. Hsu

Publikováno v: Rheumatology. 50:iii137-iii145

Background: Sacroiliac joints (SJ) involvement is a distinctive and charasteristic feature of Spondyloarthritis (SpA) and x-ray is the test routinely used to make a diagnosis. However, x-ray reveals late structural damage but cannot detect active inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef1764dc9e571462376fa36b1d34a6e9
https://doi.org/10.1093/rheumatology/ker034

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

Autor: Hui Shen, J. S. Hill Gaston, Jane C. Goodall

Publikováno v: Arthritis & Rheumatism. 60:1647-1656

Objective To analyze the frequency, surface phenotype, and cytokine secretion of CD4+ T cells in peripheral blood mononuclear cells (PBMCs) from patients with ankylosing spondylitis (AS) compared with both healthy control subjects and patients with r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b03e5a5a826eed451fe2a9e17efaa7b
https://doi.org/10.1002/art.24568

Regulatory IL4+CD8+ T cells in patients with ankylosing spondylitis and healthy controls

Autor: Han-Joo Baek, Lorna B. Jarvis, J. S. Hill Gaston, Libin Zhang

Publikováno v: Annals of the Rheumatic Diseases. 68:1345-1351

Objectives: Interleukin (IL)4+CD8+ regulatory T cells (Treg) obtained from peripheral blood mononuclear cells (PBMCs) from patients with ankylosing spondylitis (AS) by coculture with autologous dendritic cells (DC) have been previously described. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6581b05abb070e64b0fb58304ba92c01
https://doi.org/10.1136/ard.2008.088120