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Akademický článek

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection.

Autor: Steve J Webster, Sven Brode, Lou Ellis, Timothy J Fitzmaurice, Matthew J Elder, Nelson O Gekara, Panagiotis Tourlomousis, Clare Bryant, Simon Clare, Ronnie Chee, Hill J S Gaston, Jane C Goodall

Publikováno v: PLoS Pathogens, Vol 13, Iss 6, p e1006383 (2017)

The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and non-infectious insult to prevent inappropriate inflammation. Using the impo

Externí odkaz: https://doaj.org/article/cc7ab21c35704bf99075bec68f1688a5

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Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

Autor: Steve J, Webster, Sven, Brode, Lou, Ellis, Timothy J, Fitzmaurice, Matthew J, Elder, Nelson O, Gekara, Panagiotis, Tourlomousis, Clare, Bryant, Simon, Clare, Ronnie, Chee, Hill J S, Gaston, Jane C, Goodall

Publikováno v: PLoS Pathogens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d607aaade192086e743ae6844fad9ce
https://pubmed.ncbi.nlm.nih.gov/28570638

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Effect of Polymorphism of the HLA-DPA1 Chain on Presentation of Antigenic Peptides

Autor: Jane C. Goodall, S P Young, J S Gaston, J L Young

Publikováno v: Human Immunology. 54:40-47

Human T-cell clones that recognize a peptide from mycobacterial heat shock protein 60 in the context of HLA-DP were found to be sensitive to changes in the DPA1 chain of the restricting element, optimal responses being seen with the combination HLA-D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fb94fcc3a7993cde03c84f47646a0b
https://doi.org/10.1016/s0198-8859(97)00003-7

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Marked conservation of complementarity-determining region 3 of the beta-chain of TCRs recognizing a mycobacterial heat shock protein 60-derived peptide with strong sequence similarity to human heat shock protein 60

Autor: J C Goodall, J Henwood, P A Bacon, J S Gaston

Publikováno v: The Journal of Immunology. 155:2329-2338

The variable gene usage and sequence of human TCRs specific for a particular MHC/peptide combination have been investigated. The peptide comprises amino acids 456-466 of the 65-kDa Mycobacterium tuberculosis heat shock protein (hsp60), and is recogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c34b176694ea9aab35ffc5c43b3fde1
https://doi.org/10.4049/jimmunol.155.5.2329

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Human CD4+ cytolytic T cells kill antigen-pulsed target T cells by induction of apoptosis

Autor: M Rahelu, G T Williams, D S Kumararatne, G C Eaton, J S Gaston

Publikováno v: The Journal of Immunology. 150:4856-4866

Stimulation of human CD4+ T cell clones with appropriate specific peptides or with lectins in the absence of APC induces a substantial degree of cell death. We have investigated the mechanisms of induction of this cell death and show that it occurs b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed5331d64d76a3f42018cefcda2dce0e
https://doi.org/10.4049/jimmunol.150.11.4856

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Identification of Chlamydia trachomatis antigens recognized by human CD4+ T lymphocytes by screening an expression library

Autor: J C, Goodall, G, Yeo, M, Huang, R, Raggiaschi, J S, Gaston

Publikováno v: European journal of immunology. 31(5)

Identification of the immunogenic proteins that induce Chlamydia trachomatis (CT)-specific T cell responses is crucial to the development of protective vaccines and understanding the mechanisms of chlamydia-induced pathology. To characterize the targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8b2fbc74d5524cf3f1d2c073ff24592
https://pubmed.ncbi.nlm.nih.gov/11465108

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Clinical and experimental evidence for persistent Yersinia infection in reactive arthritis

Autor: J S, Gaston, C, Cox, K, Granfors

Publikováno v: Arthritis and rheumatism. 42(10)

The findings of bacterial antigens in the joint and persistent triggering infection elsewhere in the body are thought to be important in the pathogenesis of reactive arthritis (ReA). We describe a patient with clinical and laboratory features consist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e554641851b3635394636d9c44f183b8
https://pubmed.ncbi.nlm.nih.gov/10524699

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Role of T-cells in the development of arthritis

Autor: J S, Gaston

Publikováno v: Clinical science (London, England : 1979). 95(1)

1. Arthritis can be induced in rodents by priming T-cells to respond to a foreign antigen and then challenging with antigen intra-articularly. This may be a model of the situation in human reactive arthritis in which T-cell responses are induced by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81ea69a0dbc6ad02c6b5efaaf7b78af3
https://pubmed.ncbi.nlm.nih.gov/9662482

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Identification of the epitope recognized by the human V beta 5-specific monoclonal antibody 42/1C1. Potential implications for disease therapy

Autor: J, Henwood, J C, Goodall, A W, Boylston, J S, Gaston

Publikováno v: Human immunology. 42(4)

A panel of T-cell clones was generated that was specific for amino acid residues 4-13 of the mycobacterial 65-kd stress protein. All the clones were found to express a member of the V beta 5 family, as defined by PCR. However, the clones could be dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ddacdb599af7c861e38ac10f309cad02
https://pubmed.ncbi.nlm.nih.gov/7558914

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