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Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides

Autor: J S Cowdery, J H Chace, A K Yi, A M Krieg

Publikováno v: The Journal of Immunology. 156:4570-4575

Microbial products released during bacterial infection induce cytokine-mediated inflammatory responses that can be protective, but excessive release of inflammatory cytokines may promote development of the sepsis syndrome. We examined the ability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91dde4d70118080512aa2993cf7014d8
https://doi.org/10.4049/jimmunol.156.12.4570

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IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides

Autor: A K Yi, J H Chace, J S Cowdery, A M Krieg

Publikováno v: The Journal of Immunology. 156:558-564

Lymphocyte recognition of characteristic structural features in microbial DNA may contribute to immune defense by promoting protective immune responses. The dinucleotide CpG is significantly under-represented in vertebrate DNA and is usually methylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83dd78d5e5c7786ea742b68b679d3858
https://doi.org/10.4049/jimmunol.156.2.558

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T cell-independent and T cell-dependent B cell activation increases IFN-gamma R expression and renders B cells sensitive to IFN-gamma-mediated inhibition

Autor: N S Abed, J H Chace, J S Cowdery

Publikováno v: The Journal of Immunology. 153:3369-3377

We have studied the relationship between B cell activation and the ability of IFN-gamma to inhibit B cell differentiation. The LPS activation of conventional and CD5+ B cells resulted in increased IFN-gamma R expression and increased the ability of I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08171ff32eb046761ec1fce40e5de5a4
https://doi.org/10.4049/jimmunol.153.8.3369

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Primary pulmonary anthrax with septicemia

Autor: J S, COWDERY

Publikováno v: Archives of pathology. 43(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef835c66e88f6fb500e8e4e1b2d9bb86
https://pubmed.ncbi.nlm.nih.gov/20241860

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Altered IFN-gamma and IL-4 pattern lymphokine secretion in mice partially depleted of CD4 T cells by anti-CD4 monoclonal antibody

Autor: E H Field, T M Rouse, A L Fleming, I Jamali, J S Cowdery

Publikováno v: The Journal of Immunology. 149:1131-1137

Complete elimination of CD4 cells by in vivo treatment with anti-CD4 mAb may result in B cell polyclonal activation. Additionally, mice treated with doses of anti-CD4 that eliminate half the CD4 cells produced higher anti-SRBC antibody responses than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b75fb380ca92ec531b23b3272b02e27
https://doi.org/10.4049/jimmunol.149.4.1131

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Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide

Autor: J S, Cowdery, N J, Boerth, L A, Norian, P S, Myung, G A, Koretzky

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(11)

Challenge of macrophages with DNA containing an internal CpG motif results in IL-12 p40 secretion. In the presence of IFN-gamma, CpG DNA induces more p40 secretion than does LPS. In the RAW 264 macrophage cell line, both CpG DNA and LPS activate a p4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b81b77db2df07cbd2b208bec6773db40
https://pubmed.ncbi.nlm.nih.gov/10352297

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Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides

Autor: J S, Cowdery, J H, Chace, A K, Yi, A M, Krieg

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 156(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d1cbb36e63a62d8317458669aa88ecd
https://pubmed.ncbi.nlm.nih.gov/8648098

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Regulation of differentiation of peritoneal B-1a (CD5+) B cells. Activated peritoneal macrophages release prostaglandin E2, which inhibits IgM secretion by peritoneal B-1a cells

Autor: J H, Chace, A L, Fleming, J A, Gordon, C E, Perandones, J S, Cowdery

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 154(11)

The B-1a (CD5+) subset of B cells comprises the majority of B cells in the peritoneal cavity and is implicated in the pathogenesis of certain autoimmune diseases and lymphoproliferative disorders. When we stimulated purified B-1a cells with LPS, they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a94dbbbba0dfe885ff0a9fa0fdb85a65
https://pubmed.ncbi.nlm.nih.gov/7538527

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T cell-independent and T cell-dependent B cell activation increases IFN-gamma R expression and renders B cells sensitive to IFN-gamma-mediated inhibition

Autor: N S, Abed, J H, Chace, J S, Cowdery

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 153(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5789cb65119e0836d3cf5d9dde733c07
https://pubmed.ncbi.nlm.nih.gov/7523492

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Effect of anti-CD4 on CD4 subsets. I. Anti-CD4 preferentially deletes resting, naive CD4 cells and spares activated CD4 cells

Autor: J H, Chace, J S, Cowdery, E H, Field

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 152(2)

Anti-CD4 has been extensively studied in murine models of autoimmunity and transplantation. The timing of anti-CD4 administration in these systems is critical because anti-CD4 effectively blocks primary T-dependent responses but does not diminish ong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da181bd997f8c5a7fe5cfee79d6da875
https://pubmed.ncbi.nlm.nih.gov/7904288

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