Zobrazeno 1 - 10
of 20
pro vyhledávání: '"J S Blum"'
Publikováno v:
The Journal of Immunology. 158:1-4
HLA-DM- APC are unable to present soluble Ags to T cells in the context of class II DR molecules. This defect in DM- APC can be overcome by receptor-mediated delivery of Ag into cells. Ag conjugated to ligands for cell surface receptors, such as tran
Publikováno v:
The Journal of Immunology. 151:4973-4981
The macrophage mannose receptor mediates the clearance of microorganisms and glycoproteins containing terminal mannose oligosaccharides. Cell surface expression of this receptor progresses with macrophage differentiation, and thus may be critical to
Publikováno v:
Journal of biological regulators and homeostatic agents. 19(3-4)
Current evidence suggests that MHC class II-restricted CD4+ T-cells play a crucial role in orchestrating host immune responses against cancer as well as autoimmune and infectious diseases. Antigens must be processed within endosomal and lysosomal com
Publikováno v:
Journal of cellular biochemistry. 80(4)
Differentiation of osteoprogenitor cells into osteoblasts is a pivotal step during the normal development and repair of bone. Upregulation of endogenous cellular alkaline phosphatase activity (AP) is a commonly used intracellular marker for the asses
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 156
Autor:
D N, Turvy, J S, Blum
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 156
Autor:
C, Ma, P E, Whiteley, P M, Cameron, D C, Freed, A, Pressey, S L, Chen, B, Garni-Wagner, C, Fang, D M, Zaller, L S, Wicker, J S, Blum
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(12)
Following antigenic challenge, MHC-restricted T cell responses are directed against a few dominant antigenic epitopes. Here, evidence is provided demonstrating the importance of APC in modulating the hierarchy of MHC class II-restricted T cell respon
Publikováno v:
Critical reviews in immunology. 17(5-6)
Cellular immune responses are directed against a narrow set of immunodominant peptides derived from complex antigens. By contrast, epitopes that are hidden or infrequent targets of immune responses have been termed cryptic or subdominant. Although th
Publikováno v:
The Journal of biological chemistry. 271(48)
The macrophage mannose receptor specifically recognizes proteins and particles bearing mannose terminal oligosaccharide chains. In the present study, we examined the ability of newly synthesized receptor to bind ligand. Human monocyte-derived macroph
Publikováno v:
The EMBO journal. 15(22)
Antigenic peptide loading of classical major histocompatibility complex (MHC) class II molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II associated Ii peptide) for peptides derived from antigenic proteins. This