Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J S, Witte"'
Autor:
B K, Suarez, J, Lin, J S, Witte, D V, Conti, M I, Resnick, E A, Klein, J K, Burmester, D A, Vaske, T K, Banerjee, W J, Catalona
Publikováno v:
The Prostate. 45(2)
Since the publication of the first genome screen for prostate cancer (CaP) 5 years ago, over a dozen linkage studies have appeared. Most attention has been directed to chromosome 1, where two separate regions have been identified as harboring a prost
Publikováno v:
Cancer research. 60(13)
Linkage to a prostate cancer susceptibility locus was recently reported on chromosome 16q23. We now report a region exhibiting a high frequency of allelic imbalance (AI) corresponding to this locus in tumors from 51 men diagnosed with prostate cancer
Publikováno v:
Controlled clinical trials. 21(1)
It is well known that individuals can vary widely in their disease susceptibilities. One potential source of this variation is the genetic makeup of individuals, which can confer either protection or susceptibility to disease. Here we examine the eff
Publikováno v:
Statistics in medicine. 19(3)
Multiple comparisons are commonly made in epidemiologic and genetic research. How to appropriately adjust for multiple comparisons remains a controversial issue. This note demonstrates, however, that large increases in the number of comparisons has a
Autor:
P L, Paris, P A, Kupelian, J M, Hall, T L, Williams, H, Levin, E A, Klein, G, Casey, J S, Witte
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 8(10)
Prostate cancer incidence, clinical presentation, and mortality rates vary among different ethnic groups. A genetic variant of CYP3A4, a gene involved in the oxidative deactivation of testosterone, has been associated recently with prostate cancer de
Publikováno v:
Statistics in medicine. 18(21)
Statistical genetic mapping methods are powerful tools for finding genes that contribute to complex human traits. Mapping methods combine knowledge of the biological mechanisms of inheritance and the randomness inherent in those mechanisms to locate,
Publikováno v:
Genetic epidemiology. 16(3)
Genetic epidemiologists are well aware that the casewise and pairwise twin concordances are two different measures. In determining appropriate estimators for each of these measures, the method of ascertainment must be considered. Here, we derive expr
Publikováno v:
Epidemiology (Cambridge, Mass.). 9(5)
Hierarchical models can provide more reasonable and stable parameter estimates than conventional analytical approaches. This technique also deals with problems of multiple comparisons and allows one to model multilevel data within a hierarchical fram
Autor:
H J, Lin, N M, Probst-Hensch, A D, Louie, I H, Kau, J S, Witte, S A, Ingles, H D, Frankl, E R, Lee, R W, Haile
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 7(8)
Cruciferous vegetables, especially broccoli, may prevent cancer through anticarcinogenic compounds. For example, broccoli contains isothiocyanates that induce carcinogen-detoxifying enzymes. Glutathione transferase enzymes conjugate isothiocyanates,
Autor:
R W, Haile, J S, Witte, M P, Longnecker, N, Probst-Hensch, M J, Chen, J, Harper, H D, Frankl, E R, Lee
Publikováno v:
International journal of cancer. 73(4)
We conducted a large, sigmoidoscopy-based case-control study to examine the relation of intake of macronutrients, meat, and fiber to occurrence of adenomas of the large bowel. Cases were subjects diagnosed for the first time with one or more histolog