IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement

Autor: L. van Beek, J. Van den Bossche, M. de Winther, J S Verbeek, Frits Koning, K. Willems van Dijk, Patrick C.N. Rensen, Mariëtte R. Boon, S M van den Berg, A D van Dam, Amanda C. M. Pronk, Vanessa van Harmelen, C. van Kooten

Publikováno v: International Journal of Obesity, 42(2), 260-269. Nature Publishing Group
International journal of obesity (2005), 42(2), 260-269. Nature Publishing Group
International Journal of Obesity, 42(2), 260-269

BACKGROUND/OBJECTIVES: In obesity, B cells accumulate in white adipose tissue (WAT) and produce IgG, which may contribute to the development of glucose intolerance. IgG signals by binding to Fc gamma receptors (Fc gamma R) and by activating the compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa93fa6af3c01d1e08ac7eb8d805b4ad
https://research.vumc.nl/en/publications/3793dd5d-39c6-44d9-907c-a97688087817

Enhanced uptake of blood coagulation factor VIII containing immune complexes by antigen presenting cells

Autor: J. S. Verbeek, T. Rispens, Jan Voorberg, Aleksandra Wroblewska, Falk Nimmerjahn, A. ten Brinke, Ivan Peyron, J. W. Claassens, Robin B. Hartholt, Eszter Herczenik, Edith Slot, Martijn A. Nolte

Publikováno v: Journal of thrombosis and haemostasis, 15(2), 329-340. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 15(2), 329-340

Essentials Anti-factor (F) VIII antibody formation is a major complication in the treatment of hemophilia A. We investigated uptake of FVIII and FVIII immune complex by bone marrow derived dendritic cells. Immune complex formation increased uptake of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72006a1e5cfdbe923c991b3839e0ad2
https://pubmed.ncbi.nlm.nih.gov/27868337

FcγRIII (CD16)-Deficient Mice Show IgG Isotype-Dependent Protection to Experimental Autoimmune Hemolytic Anemia

Autor: J. Westermann, C. Schiller, Dirk Meyer, J. S. Verbeek, W. L. Hazenbos, R. E. Schmidt, Shozo Izui, J.E. Gessner

Publikováno v: Blood. 92:3997-4002

In autoimmune hemolytic anemia (AIHA), there is accumulating evidence for an involvement of FcγR expressed by phagocytic effector cells, but demonstration of a causal relationship between individual FcγRs and IgG isotypes for disease development is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4fa8e18c10fc3c241288bd49507a1fc
https://doi.org/10.1182/blood.v92.11.3997

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide

Autor: John F. Morris, Jwm Hoppener, Frans M. A. Hofhuis, E. J. M. De Koning, Peter J.A. Capel, A Clark, J. S. Verbeek, E R Morris, G Posthuma

Publikováno v: Proceedings of the National Academy of Sciences. 91:8467-8471

Islet amyloid polypeptide (IAPP) is the constituent peptide of amyloid deposits found in the islets of non-insulin-dependent diabetic patients. Formation of islet amyloid is associated with a progressive destruction of insulin-producing beta cells. F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bedcbf147d6e7bf10db0f4b5e3fbc49c
https://doi.org/10.1073/pnas.91.18.8467

Molecular physiology of the islet amyloid polypeptide (IAPP)/amylin gene in man, rat, and transgenic mice

Autor: H.S. Jansz, A Clark, Cornelis J.M. Lips, Jwm Hoppener, K. L. Van Hulst, E.J.P. de Koning, C. Oosterwijk, J. S. Verbeek, Peter J.A. Capel

Publikováno v: Journal of Cellular Biochemistry. 55:39-53

Islet amyloid polypeptide ("amylin") is the major protein component of amyloid deposits in pancreatic islets of type 2 (non-insulin-dependent) diabetic patients. Islet amyloid polypeptide consists of 37 amino acids, is co-produced and co-secreted wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd677e38136676476b05d202098ce90
https://doi.org/10.1002/jcb.240550006