Zobrazeno 1 - 10
of 81
pro vyhledávání: '"J S, Pober"'
Autor:
C. Albert, L. Bracaglia, A. Koide, J. DiRito, T. Lysyy, L. Harkins, C. Edwards, O. Richfield, J. Grundler, K. Zhou, E. Denbaum, G. Ketavarapu, T. Hattori, S. Perincheri, J. Langford, A. Feizi, D. Haakinson, S. A. Hosgood, M. L. Nicholson, J. S. Pober, W. M. Saltzman, S. Koide, G. T. Tietjen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Targeted nanoparticle delivery to sites of interest is important for targeted therapeutics. Here, the authors improve the targeting efficiency of antibodies on nanoparticles using a monobody adapter to correctly orientate the antibody to preserve tar
Externí odkaz:
https://doaj.org/article/ee341fcf16ed404ea4f2fab3565e0d20
Publikováno v:
The Journal of Immunology. 159:3508-3518
TNF acts on the E-selectin gene promoter at three kappa B elements and at a variant cAMP-responsive element that binds ATF2/c-Jun. In human endothelial cells, TNF rapidly induces N-terminal domain phosphorylation of both c-Jun and ATF2. Transient ove
Publikováno v:
The Journal of Immunology. 158:887-896
Persistent E-selectin expression has been proposed to be a unique property of dermal vascular endothelium that directs skin-specific homing of a subpopulation of circulating memory T cells. We compared the kinetics of E-selectin expression on culture
Publikováno v:
The Journal of Immunology. 157:3838-3844
Porcine aortic endothelial cells (PAECs), unlike human endothelial cells, express a surface protein recognized by human CTLA4Ig fusion protein that costimulates human T cells through CD28. We have cloned porcine CD86 (pCD86) from an immortalized porc
Publikováno v:
The Journal of Immunology. 156:3174-3183
Transporter associated with Ag processing-1 (TAP1) is induced by IFN-gamma more rapidly than is HLA class I. Kinetic analysis of transfectants reveals that IFN-gamma activates the TAP1 promoter more rapidly than the HLA-B7 class I promoter. A gamma-a
Autor:
R L Palmer-Crocker, J S Pober
Publikováno v:
The Journal of Immunology. 154:2838-2845
IL-4 triggers tyrosine phosphorylation of a single major substrate (M(r) 145,000) in cultured human endothelial cells (EC) as detected by Western blot of whole cell lysates or of anti-phosphotyrosine immunoprecipitates. Phosphorylation of this substr
Publikováno v:
The Journal of Immunology. 154:151-161
We compared immunologic functions of human vascular smooth muscle cells (VSMC) with those of endothelial cells (EC) cultured from saphenous vein. Both cell types can express comparable levels of MHC class II molecules. However, class II-positive VSMC
Autor:
D E Epperson, J S Pober
Publikováno v:
The Journal of Immunology. 153:5402-5412
We characterized the response of resting human CD8 T cells to allogeneic endothelial cells (EC). Both resting and IFN-gamma-pretreated EC stimulate similar CD8 T cell proliferative responses (peak, day 5 to 6), whereas only IFN-gamma-pretreated EC st
Publikováno v:
The Journal of Immunology. 153:3929-3937
The ability of cultured human endothelial cells (EC) to activate resting T cells depends on signals provided by EC that augment T cell IL-2 synthesis. EC-mediated augmentation of IL-2 secretion by PHA-activated T cells is resistant to inhibition by c
Publikováno v:
The Journal of Immunology. 151:5062-5072
Microvascular endothelial cells (EC) recruit circulating leukocytes at sites of inflammation, in part through cytokine-regulated expression of endothelial-leukocyte adhesion molecules. Adhesion molecule expression varies among vascular beds and among