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A Brief History of Human Challenge Studies (1900-2021) Emphasising the Virology, Regulatory and Ethical Requirements, Raison D'etre, Ethnography, Selection of Volunteers and Unit Design

Autor: J S, Oxford, A, Catchpole, A, Mann, A, Bell, N, Noulin, D, Gill, J R, Oxford, A, Gilbert, Shobana, Balasingam

Publikováno v: Current topics in microbiology and immunology.

Venetian quarantine 400 years ago was an important public health measure. Since 1900 this has been refined to include "challenge" or deliberate infection with pathogens be they viruses, bacteria, or parasites. Our focus is virology and ranges from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1482d283877949a0bb72ce9977a6f981
https://pubmed.ncbi.nlm.nih.gov/35704095

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Specific Inhibitors of Influenza Related to the Molecular Biology of Virus Replication

Autor: J. S. Oxford

Publikováno v: Chemoprophylaxis and Virus Infections of the Respiratory Tract ISBN: 9781351070614
Chemoprophylaxis and Virus Infections of the Respiratory Tract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52b9177029751c963560c19b0426503a
https://doi.org/10.1201/9781351070614-5

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Animal Models of Influenza Virus Infection as Applied to the Investigation of Antiviral Compounds

Autor: J. S. Oxford, C. W. Potter

Publikováno v: Chemoprophylaxis and Virus Infections of the Respiratory Tract ISBN: 9781351070621
Chemoprophylaxis and Virus Infections of the Respiratory Tract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a88020040c81c5eb3b4d7d120810ed4a
https://doi.org/10.1201/9781351070621-1

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Influenza virus infection in the second and third trimesters of pregnancy: a clinical and seroepidemiological study

Autor: David James, William L. Irving, P. Chakraverty, Adrianus C. M. Boon, J. S. Oxford, Claire L. Jameson, M. C. Zambon, D. W. G. Brown, T. Stephenson, P. Laing

Publikováno v: BJOG: An International Journal of Obstetrics and Gynaecology. 107:1282-1289

Objective To determine whether maternal influenza virus infection in the second and third trimesters of pregnancy results in transplacental transmission of infection, maternal auto-antibody production or an increase in complications of pregnancy. Des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e417fbca2c2001991f58da604b400915
https://doi.org/10.1111/j.1471-0528.2000.tb11621.x

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Influenza A pandemics of the 20th century with special reference to 1918: virology, pathology and epidemiology

Autor: J. S. Oxford

Publikováno v: Reviews in Medical Virology. 10:119-133

Influenza A virus initiated worldwide epidemics (pandemics) in 1918, 1957, 1968 and 1977. A revised calculation of the 1918-1919 pandemic estimates that 40 million persons died and 500 million were infected. The mortalities in 1957 and 1968 were near

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b2ca9264f5e8b52a004061e3197678b
https://doi.org/10.1002/(sici)1099-1654(200003/04)10:2<119::aid-rmv272>3.0.co

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The haemagglutinins of influenza A (H1N1) viruses in the ‘O’ or ‘D’ phases exhibit biological and antigenic differences

Autor: K. Zakrzewska, T. Corcoran, R.W. Newman, O. Bartolomei-Corsi, P. Yates, James S. Robertson, J. S. Oxford, Alberta Azzi

Publikováno v: Epidemiology and Infection. 111:135-142

SummaryInfluenza A (H1N1) viruses when initially isolated in mammalian cell cultures (MDCK cells) had different agglutination reactions with chicken and guinea-pig erythrocytes compared to the same viruses after passage. On first isolation the virus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5948139d5c74dea9a071dc02ed9e29ee
https://doi.org/10.1017/s0950268800056752

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Zanamivir (Glaxo Wellcome)

Autor: J S, Oxford

Publikováno v: IDrugs : the investigational drugs journal. 3(4)

Zanamivir, a neuraminidase inhibitor under license from Biota, has been developed and launched by Glaxo Wellcome for the treatment of influenza virus infection [277127]. While registered as drugs, neuraminidase inhibitors are technically vaccines as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::116b6c71a09088925078b64c68e3f274
https://pubmed.ncbi.nlm.nih.gov/16100701

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