Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J S, Mistry"'
Publikováno v:
Bulletin of Environmental Contamination and Toxicology. 47:381-385
The ubiquitous environmental pollutants organochlorine pesticides (OCP) and polycyclic aromatic hydrocarbons (PAH) have been extensively studied for their toxicity. Monitoring of OCP and PAH residues has always been considered important for controlli
Publikováno v:
Molecular pharmacology. 44(6)
Prokaryotes produce a variety of toxins that affect genomic function of both eukaryotes and prokaryotes. The 375-base pair bacterial gene Streptoalloteichus hindustanus (Sh) ble encodes a small protein, Streptoalloteichus hindustanus bleomycin resist
Publikováno v:
Molecular pharmacology. 42(1)
Bleomycin hydrolase (BH) is a cysteine proteinase that terminates the pharmacological action of bleomycin (BLM). Amino acid sequence data obtained from a tryptic digest fragment of purified rabbit lung BH were used to synthesize a 14-amino acid pepti
Publikováno v:
Cancer research. 52(10)
Metabolic inactivation of bleomycin (BLM) by cysteine proteinase-like enzymes is thought to be a major mechanism of BLM tumor resistance. We now report that the human colon carcinoma COLO-205 is highly resistant to BLM and that E-64, a cysteine prote
Synthesis and evaluation of fluoromycin: a novel fluorescence-labeled derivative of talisomycin S10b
Publikováno v:
Cancer research. 52(3)
We have synthesized fluoromycin (FLM), a novel fluorescein-labeled derivative of talisomycin S10b (TLM S10b), and used it to evaluate cellular drug accumulation and distribution in bleomycin (BLM)-sensitive and -resistant cell lines. The fluorescence
In vivo sensitization of human lung carcinoma to bleomycin by the cysteine proteinase inhibitor E-64
Publikováno v:
Oncology research. 4(2)
We recently demonstrated that the cysteine proteinase inhibitor, E-64, sensitizes human Burkitt's lymphoma (Daudi) to the antitumor action of bleomycin (BLM) by blocking its metabolism. We now report that E-64 sensitizes the BLM resistant human lung
Publikováno v:
Humanexperimental toxicology. 10(5)
Ayurvedic medicinal preparations, commonly known as bhasmas, were analysed for the determination of polycyclic aromatic hydrocarbons (PAH). All the preparations contained PAH. The level of total PAH varied widely (2.32-9.55 ppm) among the preparation
Publikováno v:
Cancer research. 51(1)
The mechanism of human tumor resistance to the antineoplastic drug bleomycin (BLM) is not known. We now provide evidence implicating metabolic inactivation in the resistance of human Burkitt's (Daudi) lymphoma to BLM. Daudi lymphoma and human head an
Publikováno v:
Chemischer Informationsdienst. 14