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Assessing the Colonic Microbiota in Children: Effects of Sample Site and Bowel Preparation

Autor: Jenny Epstein, J S Kroll, Paul Randell, Kathleen Sim, Azelea Rushd, Naomi Black, Alexander G. Shaw

Publikováno v: Journal of Pediatric Gastroenterology & Nutrition. 64:230-237

Objectives Inflammatory bowel disease (IBD) states are associated with gastrointestinal dysbiosis. Mucosal biopsy sampling, retrieving the bacterial community that most directly interacts with the host, is an invasive procedure, and we hypothesize ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129e26e374bfab355728526c99d5f265
https://doi.org/10.1097/mpg.0000000000001233

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Akademický článek

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Cross-Reactive Bactericidal Antimeningococcal Antibodies Can Be Isolated From Convalescing Invasive Meningococcal Disease Patients Using Reverse Vaccinology 2.0

Autor: Fadil A. Bidmos, J S Kroll, Gavin R. Screaton, Paul R. Langford, Simon Nadel

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)

The threat from invasive meningococcal disease remains a serious source of concern despite the licensure and availability of vaccines. A limitation of currently-available serogroup B vaccines is the breadth of coverage afforded, resulting from the ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12861c64d60e5a04532993f332f64fe
https://pubmed.ncbi.nlm.nih.gov/30061891

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Akademický článek

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Antibiotic resistance potential of the healthy preterm infant gut microbiome

Autor: J S Kroll, Ming-Shi Li, Saheer E. Gharbia, Raju Misra, Alexander G. Shaw, Kathleen Sim, David J. Wooldridge, Graham Rose

Publikováno v: PeerJ, Vol 5, p e2928 (2017)
PeerJ

Background Few studies have investigated the gut microbiome of infants, fewer still preterm infants. In this study we sought to quantify and interrogate the resistome within a cohort of premature infants using shotgun metagenomic sequencing. We descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126d2aaafc3f926c9e65556caa5f3d55
http://hdl.handle.net/10044/1/43565

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Cellular immune responses to Neisseria meningitidis in children

Autor: E M Rouppe van der Voort, Paul R. Langford, Martin L. Hibberd, C. A. Ison, Andrew J. Pollard, R Galassini, J S Kroll, Michael Levin, Robert Booy, J T Poolman, Simon Nadel

Publikováno v: Europe PubMed Central

There is an urgent need for effective vaccines against serogroup B Neisseria meningitidis . Current experimental vaccines based on the outer membrane proteins (OMPs) of this organism provide a measure of protection in older children but have been ine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd6c445d6c3163d75f8c1d48f73b63f
https://ora.ox.ac.uk/objects/uuid:f8bbed6f-ddc2-46f4-a750-31a11d0acc62

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PCR for capsular typing of Haemophilus influenzae

Autor: Duncan J. Maskell, T. J. Falla, L. N. Brophy, J. S. Kroll, Derrick W. Crook, E. R. Moxon

A PCR method for the unequivocal assignment of Haemophilus influenzae capsular type (types a to f) was developed. PCR primers were designed from capsule type-specific DNA sequences cloned from the capsular gene cluster of each of the six capsular typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e21617e67d5aad89b3d5601a075426
https://ora.ox.ac.uk/objects/uuid:2a58e346-026d-479b-b5d4-c4410323af3c

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Multiplex PCR That Can Distinguish between Immunologically Cross- Reactive Serovar 3, 6, and 8 Actinobacillus pleuropneumoniae Strains

Autor: J S Kroll, Janine T. Bossé, Joachim Frey, Paul R. Langford, Sophie Jones, Øystein Angen, L. Zhou, Huanchun Chen, John H. E. Nash, R. Zhou, Andrew N. Rycroft

Publikováno v: Journal of Clinical Microbiology. 46:800-803

We describe a highly sensitive and specific multiplex PCR, based on capsular loci and the species specific apxIV gene, that unequivocally differentiates serovar 3, 6, and 8 Actinobacillus pleuropneumoniae strains that are cross-reactive in convention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c33df4751d90327b46aa0b3c4d8181
https://doi.org/10.1128/jcm.01787-07

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High-Throughput Identification of Conditionally Essential Genes in Bacteria: From STM to TSM

Autor: Janine T. Bossé, L. Zhou, Paul R. Langford, J S Kroll

Publikováno v: Infectious Disorders - Drug Targets. 6:241-262

Signature-tagged mutagenesis (STM) provided the first widely applicable high-throughput method for detecting conditionally essential genes in bacteria by using negative selection to screen large pools of transposon (Tn) mutants. STM requires no prior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b080db1dd24106347c426496efa4b264
https://doi.org/10.2174/187152606778249917

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