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pro vyhledávání: '"J S, Janicki"'
Temporal evaluation of left ventricular remodeling and function in rats with chronic volume overload
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 271:H2071-H2078
The left ventricle (LV) significantly dilates and hypertrophies in response to chronic volume overload. However, the temporal responses in LV mass, volume, and systolic/diastolic function secondary to chronic volume overload induced by an infrarenal
Publikováno v:
Cardiovascular Research. 24:741-747
Study objective – The aim was to compare the temporal sequence and structural relationship between perivascular and interstitial fibrosis and microscopic scarring seen in the left ventricle in response to either a transient or sustained stimulus to
Autor:
J B, Caulfield, J S, Janicki
Publikováno v:
Technology and health care : official journal of the European Society for Engineering and Medicine. 5(1-2)
The extracellular collagen matrix of the myocardium plays an important role in maintaining muscle fiber and cardiac alignment and ventricular shape and size. It also influences tissue and ventricle stiffness. This network consists of an organized hie
Publikováno v:
Journal of cellular biochemistry. 63(2)
Extracellular matrix metalloproteinases (MMPs) are activated in dilated cardiomyopathic (DCM) hearts [Tyagi et al. (1996): Mol Cell Biochem 155:13-21]. To examine whether the MMP activation is occurring at the gene expression level, we performed diff
Publikováno v:
Journal of cellular physiology. 167(1)
Following myocardial infarction, extracellular matrix (ECM) is disrupted, which leads to the generation of collagen- and elastin-derived peptides (CDPs and EDPs, respectively). To investigate whether ECM-derived peptides (i.e., CDPs and EDPs) induce
Publikováno v:
The Journal of laboratory and clinical medicine. 126(3)
Elevations in plasma angiotensin II (AngII) are associated with evidence of vascular hyperpermeability expressed as efflux of plasma macromolecules into the perivascular and interstitial space. This exudative response is followed by a series of fibro
Publikováno v:
Cardiovascular research. 29(4)
The aims were to determine: (1) if angiotensin converting enzyme (ACE) inhibition and angiotensin II receptor blockade can prevent angiotensin II induced coronary vascular damage; (2) if the cardioprotective properties of ACE inhibition are dose depe
Publikováno v:
Advances in experimental medicine and biology. 382
Collagen which is present in the myocardium in relatively small amounts is the most abundant structural protein of the connective tissue network. Its structural organization consists of a complex weave of collagen fibers that surrounds and interconne
Publikováno v:
Clinics in chest medicine. 15(2)
CPX testing allows for the objective assessment of aerobic capacity, anaerobic threshold, and the ventilatory response to exercise in patients with cardiovascular disease. These results can be used to assess severity of disease, its progression over
Publikováno v:
The Journal of laboratory and clinical medicine. 121(3)
Vascular permeability of the coronary and mesenteric circulation is increased in association with the arterial hypertension that accompanies either endogenous activation of the renin-angiotensin-aldosterone system (RAAS) or exogenous administration o